Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Agnieszka Skalecka"'
Autor:
Shane Wiebe, Ziying Huang, Reese Jalal Ladak, Agnieszka Skalecka, Roberta Cagnetta, Jean-Claude Lacaille, Argel Aguilar-Valles, Nahum Sonenberg
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract The consolidation of learned information into long-lasting memories requires the strengthening of synaptic connections through de novo protein synthesis. Translation initiation factors play a cardinal role in gating the production of new pro
Externí odkaz:
https://doaj.org/article/fa462c9b622c488fb6640dee8e081d75
Autor:
Natalia L. Kononenko, Gala A. Claßen, Marijn Kuijpers, Dmytro Puchkov, Tanja Maritzen, Aleksandra Tempes, Anna R. Malik, Agnieszka Skalecka, Sujoy Bera, Jacek Jaworski, Volker Haucke
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The endocytic adaptor protein complex AP-2 is mostly known for its role in endocytosis and in synaptic vesicle reformation. Here the authors show that AP-2 also mediates retrograde transport of TrkB-containing autophagosomes in neurons; this process
Externí odkaz:
https://doaj.org/article/4d27649c1b8945efb76664268ba42b42
Autor:
Matylda Macias, Magdalena Blazejczyk, Paulina Kazmierska, Bartosz Caban, Agnieszka Skalecka, Bartosz Tarkowski, Anna Rodo, Jan Konopacki, Jacek Jaworski
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64455 (2013)
Mammalian target of rapamycin (mTOR) is a protein kinase that senses nutrient availability, trophic factors support, cellular energy level, cellular stress, and neurotransmitters and adjusts cellular metabolism accordingly. Adequate mTOR activity is
Externí odkaz:
https://doaj.org/article/f4082017b5e4443fb539dfecdb2c6876
Autor:
Shane Wiebe, Ziying Huang, Agnieszka Skalecka, Roberta Cagnetta, Jean-Claude Lacaille, Argel Aguilar-Valles, Nahum Sonenberg
The consolidation of learned information into long-lasting memories requires the strengthening of synaptic connections through de novo protein synthesis. Translation initiation factors play a cardinal role in gating the production of new proteins the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c9bbc0f1d2dfec96f150cc2cb0296f5
https://doi.org/10.21203/rs.3.rs-2121929/v1
https://doi.org/10.21203/rs.3.rs-2121929/v1
Autor:
Antonio Inserra, Justine P Enns, Luca Posa, Jelena Popic, He Qianzi, Agnieszka Skalecka, Danilo De Gregorio, Argel Aguilar-Valles, Christopher K. Lafferty, Athanasios Markopoulos, Martha Lopez-Canul, Jonathan P. Britt, Nahum Sonenberg, Stefano Comai, Gabriella Gobbi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Social behavior (SB) is a fundamental hallmark of human interaction. Repeated administration of low doses of the 5-HT2A agonist lysergic acid diethylamide (LSD) in mice enhances SB by potentiating 5-HT2A and AMPA receptor neurotransmissi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8415a277385cb4078e956e1374d984
Autor:
Shane Wiebe, Karim Nader, Argel Aguilar-Valles, Vinh Tai Truong, Ilse Gantois, Seyed Mehdi Jafarnejad, Jean-Claude Lacaille, Clément Chapat, Nahum Sonenberg, Vijendra Sharma, Jelena Popic, Erika Freemantle, Christos G. Gkogkas, Isabelle A. Groves, Anmol Nagpal, Tine Pooters, Agnieszka Skalecka, Karine Gamache, Arkady Khoutorsky, Ruifeng Cao, Elizabeth A. McCullagh
Publikováno v:
Gantois, I, Khoutorsky, A, Popic, J, Aguilar-Valles, A, Freemantle, E, Cao, R, Sharma, V, Pooters, T, Nagpal, A, Skalecka, A, Truong, V T, Wiebe, S, Groves, I A, Jafarnejad, S M, Chapat, C, McCullagh, E A, Gamache, K, Nader, K, Lacaille, J-C, Gkogkas, C G & Sonenberg, N 2017, ' Metformin ameliorates core deficits in a mouse model of fragile X syndrome ', Nature Medicine, vol. 23, pp. 674-677 . https://doi.org/10.1038/nm.4335
Fragile X syndrome (FXS) is the leading monogenic cause of autism spectrum disorders (ASD). Trinucleotide repeat expansions in FMR1 abolish FMRP expression, leading to hyperactivation of ERK and mTOR signaling upstream of mRNA translation. Here we sh
Autor:
Agnieszka Skalecka, Marijn Kuijpers, Gala A. Claßen, Sujoy Bera, Dmytro Puchkov, Jacek Jaworski, Aleksandra Tempes, Anna R. Malik, Natalia L. Kononenko, Volker Haucke, Tanja Maritzen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications, 8: 14819
Nature Communications
Nature Communications, 8: 14819
Nature Communications
Autophagosomes primarily mediate turnover of cytoplasmic proteins or organelles to provide nutrients and eliminate damaged proteins. In neurons, autophagosomes form in distal axons and are trafficked retrogradely to fuse with lysosomes in the soma. A
Autor:
Jeehyun Park, Ilse Gantois, Arkady Khoutorsky, Agnieszka Skalecka, Nahum Sonenberg, Alexander J. He, Vinh Tai Truong, Shane Wiebe, Anmol Nagpal, Karine Gamache
Translational control plays a key role in regulation of neuronal activity and behavior. Deletion of the translational repressor 4E-BP2 in mice alters excitatory and inhibitory synaptic functions, engendering autistic-like behaviors. The contribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a159fb9eebca184bde8b08ee4a53e1f7
https://europepmc.org/articles/PMC6731681/
https://europepmc.org/articles/PMC6731681/
Autor:
Anna R. Malik, Agnieszka Skalecka, Ewa Liszewska, Arkady Khoutorsky, Jacek Jaworski, Christos G. Gkogkas, Nahum Sonenberg, Robert Bilinski
Publikováno v:
Developmental Neurobiology
Skałecka, A, Liszewska, E, Bilinski, R, Gkogkas, C, Khoutorsky, A, Malik, A R, Sonenberg, N & Jaworski, J 2016, ' mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons ', Developmental neurobiology . https://doi.org/10.1002/dneu.22392
Skałecka, A, Liszewska, E, Bilinski, R, Gkogkas, C, Khoutorsky, A, Malik, A R, Sonenberg, N & Jaworski, J 2016, ' mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons ', Developmental neurobiology . https://doi.org/10.1002/dneu.22392
Neurogenesis is the process of neuron generation, which occurs not only during embryonic development but also in restricted niches postnatally. One such region is called the subventricular zone (SVZ), which gives rise to new neurons in the olfactory
Autor:
Alicja Koscielny, Matylda Macias, Ryszard Przewlocki, Jacek Jaworski, Marcin Piechota, Magdalena Blazejczyk, Michal Korostynski, Aleksandra Tempes, Malgorzata Urbanska, Agnieszka Skalecka, Marcelina Firkowska
Publikováno v:
Molecular Neurobiology
Epileptogenesis is a process triggered by initial environmental or genetic factors that result in epilepsy and may continue during disease progression. Important parts of this process include changes in transcriptome and the pathological rewiring of