Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Agnieszka Obarska"'
Autor:
Maximilian Seidel, Natalie Romanov, Agnieszka Obarska-Kosinska, Anja Becker, Nayara Trevisan Doimo de Azevedo, Jan Provaznik, Sankarshana R. Nagaraja, Jonathan J. M. Landry, Vladimir Benes, Martin Beck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Various cellular quality control mechanisms support proteostasis. While, ribosome-associated chaperones prevent the misfolding of nascent chains during translation, importins were shown to prevent the aggregation of specific cargoes in a pos
Externí odkaz:
https://doaj.org/article/55dc045fc9ed44c1b929ae9a590b88c8
Autor:
Christopher Zapp, Agnieszka Obarska-Kosinska, Benedikt Rennekamp, Markus Kurth, David M. Hudson, Davide Mercadante, Uladzimir Barayeu, Tobias P. Dick, Vasyl Denysenkov, Thomas Prisner, Marina Bennati, Csaba Daday, Reinhard Kappl, Frauke Gräter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
The existence, nature and biological relevance of mechanoradicals in proteins are unknown. Here authors show that mechanical stress on collagen produces radicals and subsequently reactive oxygen species and suggest that collagen I evolved as a radica
Externí odkaz:
https://doaj.org/article/50b8db94c94742b2bea4990163c8a11d
Autor:
Miao Yu, Maziar Heidari, Sofya Mikhaleva, Piau Siong Tan, Sara Mingu, Hao Ruan, Christopher D. Reinkemeier, Agnieszka Obarska-Kosinska, Marc Siggel, Martin Beck, Gerhard Hummer, Edward A. Lemke
Publikováno v:
Nature
The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper for the transport between the nucleus and cytosol1. The central channel of the NPC is filled with hundreds of intrinsically disordered proteins (IDPs) called FG-nucle
Autor:
Sven Fischer, Jérôme Bürgi, Shiran Gabay-Maskit, Renate Maier, Thomas Mastalski, Eden Yifrach, Agnieszka Obarska-Kosinska, Markus Rudowitz, Ralf Erdmann, Harald W. Platta, Matthias Wilmanns, Maya Schuldiner, Einat Zalckvar, Silke Oeljeklaus, Friedel Drepper, Bettina Warscheid
Publikováno v:
Biological Chemistry. 404:135-155
Peroxisomes are organelles with vital functions in metabolism and their dysfunction is associated with human diseases. To fulfill their multiple roles, peroxisomes import nuclear-encoded matrix proteins, most carrying a peroxisomal targeting signal (
Autor:
Jiasui Liu, Simon Corroyer-Dulmont, Vojtěch Pražák, Iskander Khusainov, Karola Bahrami, Sonja Welsch, Daven Vasishtan, Agnieszka Obarska-Kosińska, Sigurdur R. Thorkelsson, Kay Grunewald, Emmanuelle R. J. Quemin, Beata Turoňová, Jacomina Krijnse Locker
Although vaccinia virus (VACV) is the best studied poxvirus, the structure of the mature virus (MV) remains poorly understood. Its asymmetric shape, size and compactness poses a major challenge for electron microscopy (EM) analysis, including cryoEM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647925076c8f2a388e619b2b148774d8
https://doi.org/10.1101/2023.05.24.542031
https://doi.org/10.1101/2023.05.24.542031
Publikováno v:
Biophys J
Biophysical Journal
Biophysical Journal
Type I collagen is the main structural component of many tissues in the human body. It provides excellent mechanical properties to connective tissue and acts as a protein interaction hub. There is thus a wide interest in understanding the properties
Autor:
Vasyl Denysenkov, Uladzimir Barayeu, Marina Bennati, Csaba Daday, Agnieszka Obarska-Kosinska, Benedikt Rennekamp, Markus Kurth, Christopher Zapp, Tobias P. Dick, Frauke Gräter, David M. Hudson, Thomas F. Prisner, Davide Mercadante, Reinhard Kappl
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications
Nature Communications
As established nearly a century ago, mechanoradicals originate from homolytic bond scission in polymers. The existence, nature and biological relevance of mechanoradicals in proteins, instead, are unknown. We here show that mechanical stress on colla
Autor:
Vivian Pogenberg, Margret H. Ogmundsdottir, Romana Schober, Morlin Milewski, Agnieszka Obarska-Kosinska, Rainer Schindl, Josué Ballesteros-Álvarez, Matthias Wilmanns, Ingibjörg Sigvaldadóttir, Eiríkur Steingrímsson
Publikováno v:
'Nucleic Acids Research ', vol: 48, pages: 934-948 (2020)
Nucleic Acids Research
Nucleic Acids Research
Interrupted dimeric coiled coil segments are found in a broad range of proteins and generally confer selective functional properties such as binding to specific ligands. However, there is only one documented case of a basic-helix–loop–helix leuci
Autor:
Agnieszka Obarska-Kosinska, Aliaksandr Halavatyi, Matteo Allegretti, Martin Beck, Sara K. Goetz, Jan Kosinski, Christian E. Zimmerli, Julia Mahamid, Vasileios Rantos, Gerhard Hummer, Ievgeniia Zagoriy
Publikováno v:
Science
In eukaryotic cells, nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes and mediate nucleocytoplasmic exchange. They are made of 30 different nucleoporins and form a cylindrical architecture around an aqueous central channel. Th
Autor:
Beata Turonova, Martin Beck, Florian Schmidt, Marc Siggel, Katarzyna Buczak, Agnieszka Obarska-Kosinska, Shyamal Mosalaganti, Gerhard Hummer, Christian E. Zimmerli, Wim J. H. Hagen, Erica Margiotta, Jan Kosinski, Marie-Therese Mackmull
Nuclear pore complexes (NPCs) mediate nucleocytoplasmic transport. Their intricate 120 MDa architecture remains incompletely understood. Here, we report a near-complete structural model of the human NPC scaffold with explicit membrane and in multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74c67cf01cff9d23a20fcf1334cd233a
https://doi.org/10.1101/2021.10.26.465776
https://doi.org/10.1101/2021.10.26.465776