Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Agnieszka Kieloch"'
Autor:
Lawren VandeVrede, Amy Wolf, Elisabeth H. Thijssen, Joel H. Kramer, Howard J. Rosen, Renaud La Joie, Corrina Fonseca, Kaj Blennow, Yann Cobigo, Andreas Jeromin, Marie-Anne Valentin, Adam L. Boxer, Oskar Hansson, Lili Yu, Salvatore Spina, Niklas Mattsson-Carlgren, Amelia Strom, Bradley F. Boeve, Bruce L. Miller, Charlotte E. Teunissen, Jeffrey L. Dage, William W. Seeley, Lea T. Grinberg, Arvind Kinhikar, Gil D. Rabinovici, Argentina Lario Lago, Agnieszka Kieloch, Leonardo Iaccarino, Nicholas K. Proctor, Treatment for Frontotemporal Lobar Degeneration investigators, Rajeev Sivasankaran, Hilary W. Heuer, Julio C. Rojas, Danielle Graham, Suzanne L. Baker, Isabel E. Allen, Henrik Zetterberg
Publikováno v:
The Lancet Neurology, 20(9), 739-752. Lancet Publishing Group
Advancing Research and Treatment for Frontotemporal Lobar Degeneration investigators 2021, ' Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study ', The Lancet Neurology, vol. 20, no. 9, pp. 739-752 . https://doi.org/10.1016/S1474-4422(21)00214-3
The Lancet. Neurology, vol 20, iss 9
Advancing Research and Treatment for Frontotemporal Lobar Degeneration investigators 2021, ' Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study ', The Lancet Neurology, vol. 20, no. 9, pp. 739-752 . https://doi.org/10.1016/S1474-4422(21)00214-3
The Lancet. Neurology, vol 20, iss 9
Background: Plasma tau phosphorylated at threonine 217 (p-tau217) and plasma tau phosphorylated at threonine 181 (p-tau181) are associated with Alzheimer's disease tau pathology. We compared the diagnostic value of both biomarkers in cognitively unim
Autor:
Darren R. Hargrave, Keita Terashima, Junichi Hara, Uwe R. Kordes, Santhosh A. Upadhyaya, Felix Sahm, Eric Bouffet, Roger J. Packer, Olaf Witt, Lali Sandalic, Agnieszka Kieloch, Mark W. Russo, Kenneth J. Cohen
Publikováno v:
Journal of Clinical Oncology. 40:2009-2009
2009 Background: HGGs comprise ≈10% of pediatric central nervous system tumors and are a leading cause of childhood cancer-related death. Overall response rates (ORRs) with current standards of care are low, particularly in the second line, and 2-y
Autor:
Dario R. Alessi, David Komander, Jérôme Boudeau, Maria Deak, Daan M. F. van Aalten, Alan R. Prescott, Agnieszka Kieloch, D. Grahame Hardie, John W. Scott, Nicoletta Resta
Publikováno v:
Journal of Cell Science. 117:6365-6375
Mutations in the LKB1 tumour suppressor threonine kinase cause the inherited Peutz-Jeghers cancer syndrome and are also observed in some sporadic cancers. Recent work indicates that LKB1 exerts effects on metabolism, polarity and proliferation by pho
Autor:
Maria Deak, Liying Dong, Mike Schutkowski, C. James Hastie, Jose M. Lizcano, Nick Morrice, Dario R. Alessi, Ulf Reimer, Agnieszka Kieloch
Publikováno v:
Journal of Biological Chemistry. 277:27839-27849
The AGC family of protein kinases, which includes isoforms of protein kinase B (also known as Akt), ribosomal S6 protein kinase (S6K), and serum- and glucocorticoid-induced protein kinase (SGK) are activated in response to many extracellular signals
Autor:
Kimber, Wendy A., Laura Trinkle-Mulcahy, Cheung, Peter C. F., Maria Deak, Marsden, Louisa J., Agnieszka Kieloch, Stephen Watt, Javier, Ronald T., Alex Gray, Peter Downes, C., john lucocq, Alessi, Dario R.
Publikováno v:
University of St Andrews CRIS
PtdIns(3,4,5)P3 is an established second messenger of growth-factor and insulin-induced signalling pathways. There is increasing evidence that one of the immediate breakdown products of PtdIns(3,4,5)P3, namely PtdIns(3,4)P2, whose levels are elevated
Autor:
Gopal P. Sapkota, J. Simon C. Arthur, Agnieszka Kieloch, Maria Deak, Nick Morrice, Sonia Lain, Jose M. Lizcano, Dario R. Alessi, Michayla R. Williams
Publikováno v:
Journal of Biological Chemistry. 276:19469-19482
Peutz-Jeghers syndrome is an inherited cancer syndrome that results in a greatly increased risk of developing tumors in those affected. The causative gene is a protein kinase termed LKB1, predicted to function as a tumor suppressor. The mechanism by
Autor:
Alan R. Prescott, Hans Clevers, Annette F. Baas, Dario R. Alessi, Mike Schutkowski, Jérôme Boudeau, Agnieszka Kieloch, Nick A. Morrice, Maria Deak
Mutations in the LKB1 protein kinase result in the inherited Peutz Jeghers cancer syndrome. LKB1 has been implicated in regulating cell proliferation and polarity although little is known about how this enzyme is regulated. We recently showed that LK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba7090d418bc093ea8631ca4020f728
https://europepmc.org/articles/PMC204473/
https://europepmc.org/articles/PMC204473/
Autor:
Dario R. Alessi, Maria Deak, Jose M. Lizcano, Sally J. Leevers, Saif Alrubaie, Agnieszka Kieloch
Publikováno v:
The Biochemical journal. 374(Pt 2)
An important mechanism by which insulin regulates cell growth and protein synthesis is through activation of the p70 ribosomal S6 protein kinase (S6K). In mammalian cells, insulin-induced PI3K (phosphoinositide 3-kinase) activation, generates the lip
Autor:
Gopal P. Sapkota, Yosef Shiloh, Maria Deak, Dario R. Alessi, Susan P. Lees-Miller, Aaron A. Goodarzi, Agnieszka Kieloch, Carl Smythe, Nick Morrice
Publikováno v:
The Biochemical journal. 368(Pt 2)
The serine/threonine protein kinase LKB1 functions as a tumour suppressor, and mutations in this enzyme lead to the inherited Peutz—Jeghers cancer syndrome. We previously found that LKB1 was phosphorylated at Thr-366 in vivo, a residue conserved in
Autor:
Jose M, Lizcano, Maria, Deak, Nick, Morrice, Agnieszka, Kieloch, C James, Hastie, Liying, Dong, Mike, Schutkowski, Ulf, Reimer, Dario R, Alessi
Publikováno v:
The Journal of biological chemistry. 277(31)
The AGC family of protein kinases, which includes isoforms of protein kinase B (also known as Akt), ribosomal S6 protein kinase (S6K), and serum- and glucocorticoid-induced protein kinase (SGK) are activated in response to many extracellular signals