Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Agnieszka K. Witkiewicz"'
Autor:
Agnieszka K. Witkiewicz, Emily Schultz, Jianxin Wang, Deanna Hamilton, Ellis Levine, Tracey O’Connor, Erik S. Knudsen
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-17 (2023)
Abstract Despite widespread use and a known mechanism of action for CDK4/6 inhibitors in combination with endocrine therapy, features of disease evolution and determinants of therapeutic response in the real-world setting remain unclear. Here, a coho
Externí odkaz:
https://doaj.org/article/5de605e33d5e4dbfb69355f793daa911
Autor:
Thomas N. O’Connor, Emily Schultz, Jianxin Wang, Tracey O’Connor, Ellis Levine, Erik S. Knudsen, Agnieszka K. Witkiewicz
Publikováno v:
Cancers, Vol 16, Iss 9, p 1749 (2024)
The largest portion of breast cancer patients diagnosed after 70 years of age present with hormone receptor-positive (HR+) breast cancer subtypes. Cyclin-dependent kinase (CDK) 4/6 inhibitor treatment, in conjunction with endocrine therapy, has becom
Externí odkaz:
https://doaj.org/article/32f9744c9c294e6f8fef6f41555b1de8
Autor:
Hemn Mohammadpour, Takemasa Tsuji, Cameron R. MacDonald, Joseph L. Sarow, Hanna Rosenheck, Saeed Daneshmandi, Jee Eun Choi, Jingxin Qiu, Junko Matsuzaki, Agnieszka K. Witkiewicz, Kristopher Attwood, Bruce R. Blazar, Kunle Odunsi, Elizabeth A. Repasky, Philip L. McCarthy
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112250- (2023)
Summary: Abundant donor cytotoxic T cells that attack normal host organs remain a major problem for patients receiving allogeneic hematopoietic cell transplantation (allo-HCT). Despite an increase in our knowledge of the pathobiology of acute graft v
Externí odkaz:
https://doaj.org/article/f1e3b8cf52994b1c9c4108441a3ac6b7
Autor:
Narmen Azazmeh, Benjamin Assouline, Eitan Winter, Shmuel Ruppo, Yuval Nevo, Alexander Maly, Karen Meir, Agnieszka K. Witkiewicz, Jonathan Cohen, Sophia V. Rizou, Eli Pikarsky, Chen Luxenburg, Vassilis G. Gorgoulis, Ittai Ben-Porath
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
It is unclear how resident p16-expressing senescent cells affect the propensity of tissues to develop cancer. Here, the authors show that chronic p16 expression in the mouse epidermis causes hyperplasia and dysplasia through Wnt-mediated paracrine st
Externí odkaz:
https://doaj.org/article/61ce1bf5407c4803ae109b815ded6484
Autor:
Agnieszka K. Witkiewicz, Sejin Chung, Rachel Brough, Paris Vail, Jorge Franco, Christopher J. Lord, Erik S. Knudsen
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1185-1199 (2018)
Summary: Approximately 30% of triple-negative breast cancers (TNBCs) exhibit functional loss of the RB tumor suppressor, suggesting a target for precision intervention. Here, we use drug screens to identify agents specifically antagonized by the reti
Externí odkaz:
https://doaj.org/article/3487547192bb459398b96c12f7aa104f
Autor:
Mark K. Farrugia, Mark D. Long, David M. Mattson, Leayn T. Flaherty, Bowen Dong, Eduardo Cortes Gomez, Lei Wei, Agnieszka K. Witkiewicz, Song Yao, Pawel Kalinski, Anurag K. Singh
Publikováno v:
Cancers, Vol 13, Iss 2, p 205 (2021)
Background: The benefit of aspirin in rectal cancer during chemoradiation therapy (CRT) and the factors affecting its efficacy are not well characterized. We compared the outcomes of rectal patients undergoing neoadjuvant CRT based on aspirin use. Me
Externí odkaz:
https://doaj.org/article/37d28616c3324cefa9c4071c76720c44
Autor:
Agnieszka K. Witkiewicz, Uthra Balaji, Cody Eslinger, Elizabeth McMillan, William Conway, Bruce Posner, Gordon B. Mills, Eileen M. O’Reilly, Erik S. Knudsen
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 2017-2031 (2016)
Pancreatic ductal adenocarcinoma (PDAC) harbors the worst prognosis of any common solid tumor, and multiple failed clinical trials indicate therapeutic recalcitrance. Here, we use exome sequencing of patient tumors and find multiple conserved genetic
Externí odkaz:
https://doaj.org/article/a48c60604edc4d72a656d77e93f20118
Publikováno v:
Cell Reports, Vol 14, Iss 5, Pp 979-990 (2016)
Summary: Due to loss of p16ink4a in pancreatic ductal adenocarcinoma (PDA), pharmacological suppression of CDK4/6 could represent a potent target for treatment. In PDA models, CDK4/6 inhibition had a variable effect on cell cycle but yielded accumula
Externí odkaz:
https://doaj.org/article/a785a3416b9b4ec093e461c953562be1
Autor:
GuemHee Baek, Yan F. Tse, Zeping Hu, Derek Cox, Noah Buboltz, Peter McCue, Charles J. Yeo, Michael A. White, Ralph J. DeBerardinis, Erik S. Knudsen, Agnieszka K. Witkiewicz
Publikováno v:
Cell Reports, Vol 9, Iss 6, Pp 2233-2249 (2014)
KRAS mutation, which occurs in ∼95% of pancreatic ductal adenocarcinoma (PDA), has been shown to program tumor metabolism. MCT4 is highly upregulated in a subset of PDA with a glycolytic gene expression program and poor survival. Models with high l
Externí odkaz:
https://doaj.org/article/92ff6c7377ad4f33a105732092c3e391
Publikováno v:
Case Reports in Gastroenterology, Vol 3, Iss 3, Pp 418-423 (2009)
Mycophenolate mofetil (CellCept®), a commonly used immunosuppressive drug in solid organ transplantation, has recently been shown to cause graft-versus-host disease (GVHD)-like changes in the gastrointestinal tract. On rare occasions, true GVHD has
Externí odkaz:
https://doaj.org/article/5fdfc39565604142a0dc4c89d3d421f2