Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Agnieszka K. Rzadzinska"'
Autor:
Agnieszka K Rzadzinska, Elisa M Nevalainen, Haydn M Prosser, Pekka Lappalainen, Karen P Steel
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7097 (2009)
In vertebrates hearing is dependent upon the microvilli-like mechanosensory stereocilia and their length gradation. The staircase-like organization of the stereocilia bundle is dynamically maintained by variable actin turnover rates. Two unconvention
Externí odkaz:
https://doaj.org/article/d0faaa97b07c49db9f744e280a68236b
Autor:
Ronna Hertzano, Ella Shalit, Agnieszka K Rzadzinska, Amiel A Dror, Lin Song, Uri Ron, Joshua T Tan, Alina Starovolsky Shitrit, Helmut Fuchs, Tama Hasson, Nir Ben-Tal, H Lee Sweeney, Martin Hrabe de Angelis, Karen P Steel, Karen B Avraham
Publikováno v:
PLoS Genetics, Vol 4, Iss 10, p e1000207 (2008)
Myosin VI, found in organisms from Caenorhabditis elegans to humans, is essential for auditory and vestibular function in mammals, since genetic mutations lead to hearing impairment and vestibular dysfunction in both humans and mice. Here, we show th
Externí odkaz:
https://doaj.org/article/c93a49e10cf3424f8f87e51adb39ccf6
Autor:
Walter, Marcotti, Laura F, Corns, Richard J, Goodyear, Agnieszka K, Rzadzinska, Karen B, Avraham, Karen P, Steel, Guy P, Richardson, Corné J, Kros
Publikováno v:
The Journal of Physiology
Key points The transduction of sound into electrical signals occurs at the hair bundles atop sensory hair cells in the cochlea, by means of mechanosensitive ion channels, the mechano‐electrical transducer (MET) channels.The MET currents decline dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6439dc6a9d92cdafc06ac30ffe2e8f11
https://pubmed.ncbi.nlm.nih.gov/27111754
https://pubmed.ncbi.nlm.nih.gov/27111754
Autor:
Chonnettia Jones, Ping Chen, Dong Qian, Xing Dai, Sharayne Mark, Xiaohui Zhang, Karen P. Steel, Agnieszka K. Rzadzinska
Publikováno v:
Developmental Biology. 306(1):121-133
Planar cell polarity (PCP) refers to the polarization of cells within the plane of a cell sheet. A distinctive epithelial PCP in vertebrates is the uniform orientation of stereociliary bundles of the sensory hair cells in the mammalian cochlea. In ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919a02beed8a76c72f2af3cb0d07a338
Publikováno v:
Cell Motility and the Cytoskeleton
Stereocilia, finger-like projections forming the hair bundle on the apical surface of sensory hair cells in the cochlea, are responsible for mechanosensation and ultimately the perception of sound. The actin cytoskeleton of the stereocilia contains h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756ee99cbf8343a0d7f1e5931e262700
http://europepmc.org/articles/PMC2682331
http://europepmc.org/articles/PMC2682331
Autor:
Gavin P. Riordan, Bechara Kachar, Caroline Davies, Agnieszka K. Rzadzinska, Mark E. Schneider
Publikováno v:
The Journal of Cell Biology
We have previously shown that the seemingly static paracrystalline actin core of hair cell stereocilia undergoes continuous turnover. Here, we used the same approach of transfecting hair cells with actin–green fluorescent protein (GFP) and espin-GF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc075f4953512a88c7def15f148320b8
https://doi.org/10.1083/jcb.200310055
https://doi.org/10.1083/jcb.200310055
Autor:
Agnieszka K. Rzadzinska, Benjamin J. Perrin, Duan Sun Zhang, J. Collin Poczatek, Claude Lechene, James M. Ervasti, David P. Corey, Valeria Piazza, Mei Wang, Haydn M. Prosser
Publikováno v:
Nature
Multi-isotope imaging mass spectrometry is used to quantify protein turnover in animal stereocilia, showing that rapid turnover occurs only in stereocilia tips. In the auditory system, the mechanosensory hair cells of the inner ear convert sound-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bc81bd3668f1aef542e292778b8476
https://pubmed.ncbi.nlm.nih.gov/22281592
https://pubmed.ncbi.nlm.nih.gov/22281592
Autor:
Haydn M. Prosser, Agnieszka K. Rzadzinska, Elisa M. Nevalainen, Pekka Lappalainen, Karen P. Steel
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7097 (2009)
PLoS ONE
PLoS ONE
In vertebrates hearing is dependent upon the microvilli-like mechanosensory stereocilia and their length gradation. The staircase-like organization of the stereocilia bundle is dynamically maintained by variable actin turnover rates. Two unconvention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc573411c50cde2f5925ee9bf972773f
http://europepmc.org/articles/PMC2743196?pdf=render
http://europepmc.org/articles/PMC2743196?pdf=render
Publikováno v:
Molecular and cellular biology. 28(5)
We have developed a bacterial artificial chromosome transgenesis approach that allowed the expression of myosin VIIa from the mouse X chromosome. We demonstrated the complementation of the Myo7a null mutant phenotype producing a fine mosaic of two ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44989ef4e31524bfad22db94c0669fce
https://pubmed.ncbi.nlm.nih.gov/18160714
https://pubmed.ncbi.nlm.nih.gov/18160714
Autor:
Bechara Kachar, Konrad Noben-Trauth, James R. Bartles, Mark Schneider, Agnieszka K. Rzadzinska
Publikováno v:
Cell motility and the cytoskeleton. 62(3)
Hearing and balance depend on microvilli-like actin-based projections of sensory hair cells called stereocilia. Their sensitivity to mechanical displacements on the nanometer scale requires a highly organized hair bundle in which the physical dimensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa50793f62ccdd7f312462410c52333
https://pubmed.ncbi.nlm.nih.gov/16206170
https://pubmed.ncbi.nlm.nih.gov/16206170