Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Agnieszka K Zielinska"'
Autor:
Lara N Mrak, Agnieszka K Zielinska, Karen E Beenken, Ian N Mrak, Danielle N Atwood, Linda M Griffin, Chia Y Lee, Mark S Smeltzer
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38453 (2012)
Mutation of the staphylococcal accessory regulator (sarA) limits biofilm formation in diverse strains of Staphylococcus aureus, but there are exceptions. One of these is the commonly studied strain Newman. This strain has two defects of potential rel
Externí odkaz:
https://doaj.org/article/c984e45f8b7e4ff7927409ed1e87473a
Autor:
Karen E Beenken, Lara N Mrak, Linda M Griffin, Agnieszka K Zielinska, Lindsey N Shaw, Kelly C Rice, Alexander R Horswill, Kenneth W Bayles, Mark S Smeltzer
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10790 (2010)
The accessory gene regulator (agr) and staphylococcal accessory regulator (sarA) play opposing roles in Staphylococcus aureus biofilm formation. There is mounting evidence to suggest that these opposing roles are therapeutically relevant in that muta
Externí odkaz:
https://doaj.org/article/a45cb04dcd5d4d379a37a9e3bd852ae3
Autor:
Karen E. Beenken, Horace J. Spencer, Robert A. Skinner, Chia Y. Lee, Agnieszka K. Zielinska, Mark S. Smeltzer, K. Alice Matthews, Allison M. Anthony, Linda M. Griffin, Ginell R. Post, Danielle N. Atwood, Lara N. Mrak, Allister J. Loughran
Publikováno v:
Molecular Microbiology. 92:1299-1312
We investigated the in vivo relevance of the impact of sarA and saeRS on protease production using derivatives of the USA300 strain LAC. The results confirmed that mutation of saeRS or sarA reduces virulence in a bacteremia model to a comparable degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1472e4d4a698d394c23f5cb661165d36
https://doi.org/10.1111/mmi.12629
https://doi.org/10.1111/mmi.12629
Autor:
Robert A. Skinner, Alan J. Tackett, Karen E. Beenken, Lara N. Mrak, Alexander R. Horswill, Horace J. Spencer, Agnieszka K. Zielinska, Mark S. Smeltzer, Ginell R. Post
Publikováno v:
Molecular Microbiology. 86:1183-1196
Mutation of staphylococcal accessory regulator (sarA) results in increased production of extracellular proteases in Staphylococcus aureus, which has been correlated with decreased biofilm formation and decreased accumulation of extracellular toxins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab8e62453130e17f79e9f6c5ee97cb61
https://doi.org/10.1111/mmi.12048
https://doi.org/10.1111/mmi.12048
Autor:
Agnieszka K. Zielinska, Grover P. Miller, Jeffery H. Moran, Cheryl F. Lichti, Moshe Finel, Anna Gallus-Zawada, Paul L. Prather, Anna Mazur, Stacie M. Bratton, Anna Radominska-Pandya
Publikováno v:
Drug Metabolism and Disposition. 37:1496-1504
Tetrahydrocannabinol (Delta(9)-THC), the primary psychoactive ingredient in marijuana, is subject to cytochrome P450 oxidation and subsequent UDP-glucuronosyltransferase (UGT)-dependent glucuronidation. Many studies have shown that CYP2C9 and CYP3A4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5dcac4201446b13e27999e4edcc7b2
https://doi.org/10.1124/dmd.109.026898
https://doi.org/10.1124/dmd.109.026898
Autor:
Stacie M. Bratton, Anna Radominska-Pandya, Anna Mazur, Cheryl F. Lichti, Grover P. Miller, Jeffery H. Moran, Moshe Finel, Anna Gallus-Zawada, Agnieszka K. Zielinska
Publikováno v:
Drug Metabolism and Disposition. 36:2211-2218
Recent studies show that the extrahepatic human UDP-glucuronosyltransferase (UGT)1A10 is capable of phase II glucuronidation of several major cytochrome P450 metabolites of warfarin (i.e., 6-, 7-, and 8-hydroxywarfarin). This study expands on this fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45d7e8ea0f139f10afb1d7491164063
https://doi.org/10.1124/dmd.108.022863
https://doi.org/10.1124/dmd.108.022863
Autor:
Michael J. Miley, Stacie M. Bratton, Moshe Finel, Adrian Goldman, Agnieszka K. Zielinska, Grover P. Miller, Anne-Sisko Patana, Yan Xiong, Matthew R. Redinbo, Anna Radominska-Pandya
Publikováno v:
Drug Metabolism and Disposition. 36:517-522
All UDP-glucuronosyltransferase enzymes (UGTs) share a common cofactor, UDP-glucuronic acid (UDP-GlcUA). The binding site for UDP-GlcUA is localized to the C-terminal domain of UGTs on the basis of amino acid sequence homology analysis and crystal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfffe195389cd80a72d2a64c31e56e75
https://doi.org/10.1124/dmd.107.016469
https://doi.org/10.1124/dmd.107.016469
Autor:
Agnieszka K, Zielinska, Karen E, Beenken, Lara N, Mrak, Horace J, Spencer, Ginell R, Post, Robert A, Skinner, Alan J, Tackett, Alexander R, Horswill, Mark S, Smeltzer
Publikováno v:
Molecular microbiology. 86(5)
Mutation of staphylococcal accessory regulator (sarA) results in increased production of extracellular proteases in Staphylococcus aureus, which has been correlated with decreased biofilm formation and decreased accumulation of extracellular toxins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::199e072460aac150e9316d18fa96728e
https://pubmed.ncbi.nlm.nih.gov/23075270
https://pubmed.ncbi.nlm.nih.gov/23075270
Publikováno v:
Blood. 126:5346-5346
As molecular profiling technologies have evolved, our understanding of multiple myeloma heterogeneity and the relative effectiveness of treatment options have increased dramatically. Most recently, next generation sequencing (NGS) studies have provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab02e78ee33095be056503f62672c52
https://doi.org/10.1182/blood.v126.23.5346.5346
https://doi.org/10.1182/blood.v126.23.5346.5346
Autor:
Linda M. Griffin, Michael Otto, Thanh T. Luong, Karen E. Beenken, Hwang-Soo Joo, Lara N. Mrak, Agnieszka K. Zielinska, Mark S. Smeltzer, Chia Y. Lee, Lindsey N. Shaw
Publikováno v:
Journal of bacteriology. 193(12)
We demonstrate that mutation of the staphylococcal accessory regulator ( sarA ) limits the accumulation of alpha-toxin and phenol-soluble modulins (PSMs) in Staphylococcus aureus isolates of the USA300 clonal lineage. Degradation assays and experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9c698088cbc947aaaeb86122194d69
https://pubmed.ncbi.nlm.nih.gov/21478342
https://pubmed.ncbi.nlm.nih.gov/21478342