Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Agnieszka K Bronowska"'
Autor:
Tom J. Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance. The Mycobacterium tuberculosis NTase toxin family, MenT, modifies tRNAs to block tra
Externí odkaz:
https://doaj.org/article/0b8cfa70586a40899ff0c0d5f6b0b175
Autor:
Daniel Trnka, Anna D. Engelke, Manuela Gellert, Anna Moseler, Md Faruq Hossain, Tobias T. Lindenberg, Luca Pedroletti, Benjamin Odermatt, João V. de Souza, Agnieszka K. Bronowska, Tobias P. Dick, Uli Mühlenhoff, Andreas J. Meyer, Carsten Berndt, Christopher Horst Lillig
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Glutaredoxins are a family of essential enzymes divided into two major classes with either a CGFS or a CxxC active site, of which only the latter exhibits oxidoreductase activity. Here the authors address the structural basis for the functional diffe
Externí odkaz:
https://doaj.org/article/8fb263e3eb754914a52c1efef5e3202b
Autor:
Francesc Sabanés Zariquiey, João V. da Souza, Roger Estrada-Tejedor, Agnieszka K. Bronowska
Publikováno v:
ACS Omega, Vol 4, Iss 9, Pp 13913-13921 (2019)
Externí odkaz:
https://doaj.org/article/292328f54cdc4d4ea7318529241bec72
Autor:
Amelia Stennett, Kallie Friston, Claire L. Harris, Adam J. M. Wollman, Agnieszka K. Bronowska, Katrina S. Madden
Publikováno v:
Expert Opinion on Therapeutic Targets. 27:97-109
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf45eb6cefc44c141e776213d6238bcf
https://doi.org/10.1080/14728222.2023.2177532
https://doi.org/10.1080/14728222.2023.2177532
Autor:
Marcel Imber, Vu Van Loi, Sylvia Reznikov, Verena Nadin Fritsch, Agnieszka J. Pietrzyk-Brzezinska, Janek Prehn, Chris Hamilton, Markus C. Wahl, Agnieszka K. Bronowska, Haike Antelmann
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 557-568 (2018)
Staphylococcus aureus produces bacillithiol (BSH) as major low molecular weight (LMW) thiol which functions in thiol-protection and redox-regulation by protein S-bacillithiolation under hypochlorite stress. The aldehyde dehydrogenase AldA was identif
Externí odkaz:
https://doaj.org/article/94504a5c1d8d453a8472966d7cb8a85a
Autor:
Bernadette Carroll, Elsje G. Otten, Diego Manni, Rhoda Stefanatos, Fiona M. Menzies, Graham R. Smith, Diana Jurk, Niall Kenneth, Simon Wilkinson, Joao F. Passos, Johannes Attems, Elizabeth A. Veal, Elisa Teyssou, Danielle Seilhean, Stéphanie Millecamps, Eeva-Liisa Eskelinen, Agnieszka K. Bronowska, David C. Rubinsztein, Alberto Sanz, Viktor I. Korolchuk
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The cellular mechanisms underlying autophagy are conserved; however it is unclear how they evolved in higher organisms. Here the authors identify two oxidation-sensitive cysteine residues in the autophagy receptor SQSTM1/p62 in vertebrates which allo
Externí odkaz:
https://doaj.org/article/9d95b336540a41c68ad4e7b54566d6ac
Autor:
Nicolas Duchemin, Sidonie Aubert, João V. de Souza, Lucas Bethge, Stefan Vonhoff, Agnieszka K. Bronowska, Michael Smietana, Stellios Arseniyadis
Publikováno v:
JACS Au. 2:1910-1917
By harnessing the chirality of the DNA double helix, chemists have been able to obtain new, reliable, selective, and environmentally friendly biohybrid catalytic systems with tailor-made functions. Nonetheless, despite all the advances made throughou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978f75f9cb158b649a551fc7c12d1cc1
https://doi.org/10.1021/jacsau.2c00271
https://doi.org/10.1021/jacsau.2c00271
Autor:
Shangze Xu, Matthew D. Kondal, Ayaz Ahmad, Ruidi Zhu, Lanyu Fan, Piotr Zaborniak, Katrina S. Madden, João V. de Souza, Agnieszka K. Bronowska
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1270
The androgen receptor (AR) is an important drug target in prostate cancer and a driver of castration-resistant prostate cancer (CRPC). A significant challenge in designing effective drugs lies in targeting constitutively active AR variants and, most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f00d5f8e1a26697e3b09438718b67d
Autor:
Chloe L. Eastabrook, Miguel Morales Maqueda, Charlotte Vagg, Joyce Idomeh, Taskeen A. Nasif-Whitestone, Poppy Lawrence, Agnieszka K. Bronowska, John H. Bothwell, Brett J. Sallach, Joe Redfern, Gary S. Caldwell
1AbstractA series of mass mortalities (wash-ups) of marine life were documented along England’s north east coastline with peaks in September and October 2021, coincident with a programme of intensified maintenance dredging of the River Tees. Decapo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::500ff3655821885425d75ed108e27837
https://doi.org/10.1101/2022.11.17.516169
https://doi.org/10.1101/2022.11.17.516169
Autor:
Lan Z. Wang, Miller Duncan Charles, Bernard T. Golding, Ian Hickson, Martin E.M. Noble, Celine Cano, Suzannah J. Harnor, Michael J. Waring, Harry J Shrives, Shaimaa Khalifa, Jane Totobenazara, Stephen J. Hobson, Elaine Willmore, Hannah L Stewart, Mathew P. Martin, Susan J. Tudhope, Huw D. Thomas, Islam Al-Khawaldeh, Claire E. Jennings, João V de Souza, Max J. Temple, Jane A. Endicott, Cinzia Bordoni, Honorine Lebraud, Agnieszka K. Bronowska, Ian R. Hardcastle, Amy B. Heptinstall, Stephen R. Wedge, Christine Basmadjian, Gregory G Aldred, Julie A. Tucker, Mohammed J Al Yasiri
Publikováno v:
Journal of Medicinal Chemistry. 64:10001-10018
NF-κB-inducing kinase (NIK) is a key enzyme in the noncanonical NF-κB pathway, of interest in the treatment of a variety of diseases including cancer. Validation of NIK as a drug target requires potent and selective inhibitors. The protein contains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56300566066f33b5e78d20a96b537040
https://doi.org/10.1021/acs.jmedchem.0c01249
https://doi.org/10.1021/acs.jmedchem.0c01249