Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Agnieszka Janska"'
Autor:
Panchali Goswami, Ferdos Abid Ali, Max E. Douglas, Julia Locke, Andrew Purkiss, Agnieszka Janska, Patrik Eickhoff, Anne Early, Andrea Nans, Alan M. C. Cheung, John F. X. Diffley, Alessandro Costa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Eukaryotic origin firing depends on assembly of the Cdc45-MCM-GINS (CMG) helicase, which requires the leading-strand polymerase Pol ɛ. Here the authors present a structural analysis of a CMG Pol ɛ on a DNA fork, providing insight on the steps leadi
Externí odkaz:
https://doaj.org/article/9aa43b820ec5447a9b984fff5621c4e6
Publikováno v:
Molecular Cell
Summary The eukaryotic replisome is a molecular machine that coordinates the Cdc45-MCM-GINS (CMG) replicative DNA helicase with DNA polymerases α, δ, and ε and other proteins to copy the leading- and lagging-strand templates at rates between 1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317c90c73bd3c6de1d0b28d6e5886ba5
https://doi.org/10.1016/j.molcel.2016.11.017
https://doi.org/10.1016/j.molcel.2016.11.017
Publikováno v:
Nature
Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome duplication in every cell cycle. To accomplish this, initiation is partitioned into two temporally discrete steps: a double hex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89cd5e58dd690bde2f2deeb2c9f1704
http://europepmc.org/articles/PMC4874468
http://europepmc.org/articles/PMC4874468