Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Agnieszka Gembarska"'
Autor:
Vincent Romanet, Marion Wiesmann, Roland Rad, Eric Durand, William R. Sellers, Audrey Kauffmann, Sébastien Jeay, Francesco Hofmann, Armelle Grevot, Agnieszka Gembarska, Antoine de Weck, Emeline Mandon, Ralph Tiedt, Louise Barys, Esther Sutter, Michael Rugaard Jensen, Stephane Ferretti, Masato Murakami, Pierre Moulin, Joseph Lehar, Emilie A. Chapeau, Claire Estadieu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(12)
Inhibitors of double minute 2 protein (MDM2)-tumor protein 53 (TP53) interaction are predicted to be effective in tumors in which the TP53 gene is wild type, by preventing TP53 protein degradation. One such setting is represented by the frequent CDKN
Autor:
Johan Lennartsson, Agnieszka Gembarska, Carl-Henrik Heldin, Kenichi Amagasaki, Aleksandra Jurek
Publikováno v:
Journal of Biological Chemistry. 284:4626-4634
MAPK phosphatases (MKPs) are dual specificity phosphatases that dephosphorylate and thereby inactivate MAPKs. In the present study, we provide evidence that platelet-derived growth factor BB (PDGF-BB) regulates MKP3 (DUSP6), which is considered to be
Autor:
Carsten Willam, Kristin Franke, Claudia Waskow, Soulafa Mamlouk, Ronald Naumann, Joanna Kalucka, Tatyana Grinenko, Georg Breier, Agnieszka Gembarska, Konstantinos Anastassiadis, Triantafyllos Chavakis, A. Francis Stewart, Antje Muschter, Ben Wielockx, Stefan R. Bornstein, Rashim Pal Singh
Publikováno v:
Singh, R P, Franke, K, Kalucka, J, Mamlouk, S, Muschter, A, Gembarska, A, Grinenko, T, Willam, C, Naumann, R, Anastassiadis, K, Stewart, A F, Bornstein, S, Chavakis, T, Breier, G, Waskow, C & Wielockx, B 2013, ' HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress ', Blood, vol. 121, no. 26, pp. 5158-66 . https://doi.org/10.1182/blood-2012-12-471185
Hypoxia is a prominent feature in the maintenance of hematopoietic stem cell (HSC) quiescence and multipotency. Hypoxia-inducible factor (HIF) prolyl hydroxylase domain proteins (PHDs) serve as oxygen sensors and may therefore regulate this system. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa749023d109c5e8f4e2a10e40039c5
https://pure.au.dk/portal/da/publications/hif-prolyl-hydroxylase-2-phd2-is-a-critical-regulator-of-hematopoietic-stem-cell-maintenance-during-steadystate-and-stress(7c795c8c-8309-4707-9e01-a7597bc56166).html
https://pure.au.dk/portal/da/publications/hif-prolyl-hydroxylase-2-phd2-is-a-critical-regulator-of-hematopoietic-stem-cell-maintenance-during-steadystate-and-stress(7c795c8c-8309-4707-9e01-a7597bc56166).html
Autor:
Sue Haupt, Ygal Haupt, Jean-Christophe Marine, Michael Dewaele, Aart G. Jochemsen, Elisabeth A. Russell, Roger S. Lo, Stephanie Villar, Flavie Luciani, Hubing Shi, Federico Bernal, Clare G Fedele, Mark Shackleton, Aleksandra Zwolinska, Lionel Larue, Dana Yip, Agnieszka Gembarska, Job de Lange, James S. Goydos, Gatien Moriceau, Ghanem Elias Ghanem, Jody J. Haigh
Publikováno v:
Gembarska, A, Luciani, F, Fedele, C, Russell, E A, Dewaele, M, Villar, S, Zwolinska, A, Haupt, S, de Lange, J, Yip, D, Goydos, J, Haigh, J J, Haupt, Y, Larue, L, Jochemsen, A, Shi, H, Moriceau, G, Lo, R S, Ghanem, G, Shackleton, M, Bernal, F & Marine, J-C 2012, ' MDM4 is a key therapeutic target in cutaneous melanoma ', Nature Medicine, vol. 18, no. 8, pp. 1239-1247 . https://doi.org/10.1038/nm.2863
Nature Medicine, 18(8), 1239
Nature Medicine, 18(8), 1239-1247. Nature Publishing Group
Nature Medicine, 18(8), 1239
Nature Medicine, 18(8), 1239-1247. Nature Publishing Group
The inactivation of the p53 tumor suppressor pathway, which often occurs through mutations in TP53 (encoding tumor protein 53) is a common step in human cancer. However, in melanoma-A highly chemotherapy-resistant disease-TP53 mutations are rare, rai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d4067186a4320ccbd9b155e81ac59a
https://research.vumc.nl/en/publications/532cece1-746b-413c-8211-14e34256a071
https://research.vumc.nl/en/publications/532cece1-746b-413c-8211-14e34256a071
Autor:
Agnieszka Gembarska, Jean-Christophe Marine, Katharina Haigh, Geertrui Denecker, Michael Naessens, Jody J. Haigh, Sarah De Clercq, Marion M. Maetens
Mdm2 and Mdm4 are critical negative regulators of p53. A large body of evidence indicates that elevated expression of either Mdm2 or Mdm4 may favor tumor formation by inhibiting p53 tumor suppression function. To explore this possibility in vivo, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c914a2d2364f795bbcede657a0e529
https://europepmc.org/articles/PMC2976380/
https://europepmc.org/articles/PMC2976380/
Autor:
Mansour Karimi, Ilse De Vos, Pierre Hilson, Lieven Haenebalcke, Agnieszka Gembarska, Steven Goossens, Bram De Craene, Sarah De Clercq, András D Nagy, Jean-Christophe Marine, Benjamin Drogat, Sonia Bartunkova, Jody J. Haigh, Omar Nyabi, Geert Berx, Michael Naessens, Marion M. Maetens, Katharina Haigh
Publikováno v:
Nucleic acids research, 37 (7
Nucleic Acids Research
Nucleic Acids Research
The ability to rapidly and efficiently generate reliable Cre/loxP conditional transgenic mice would greatly complement global high-throughput gene targeting initiatives aimed at identifying gene function in the mouse. We report here the generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7bdab53f103d263e2600641ca4e4c2
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/116486
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/116486