Carboranyl-1,8-naphthalimide intercalators induce lysosomal membrane permeabilization and ferroptosis in cancer cell lines

Autor: Sebastian Rykowski, Dorota Gurda-Woźna, Agnieszka Fedoruk-Wyszomirska, Marta Orlicka-Płocka, Aleksandra Kowalczyk, Paweł Stączek, Marta Denel-Bobrowska, Katarzyna Biniek-Antosiak, Wojciech Rypniewski, Eliza Wyszko, Agnieszka B. Olejniczak

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

The synthesis of carborane-1,8-naphthalimide conjugates and evaluation of their DNA-binding ability and anticancer activity were performed. A series of 4-carboranyl-3-nitro-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, were synthesi

Externí odkaz: https://doaj.org/article/da14e44f868943c69fa7db724c26232b

Down-regulation of tenascin-C inhibits breast cancer cells development by cell growth, migration, and adhesion impairment.

Autor: Dariusz Wawrzyniak, Małgorzata Grabowska, Paweł Głodowicz, Konrad Kuczyński, Bogna Kuczyńska, Agnieszka Fedoruk-Wyszomirska, Katarzyna Rolle

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0237889 (2020)

Tenascin-C (TNC) is an extracellular matrix (ECM) glycoprotein that plays an important role in cell proliferation, migration, and tumour invasion in various cancers. TNC is one of the main protein overexpressed in breast cancer, indicating a role for

Externí odkaz: https://doaj.org/article/695f49d0122c4e86960e9e866e69bffb

Cholesterol-Bearing Fluorescent G-Quadruplex Potassium Probes for Anchoring at the Langmuir Monolayer and Cell Membrane

Autor: Angelika Świtalska, Anna Dembska, Agnieszka Fedoruk-Wyszomirska, Bernard Juskowiak

Publikováno v: Sensors, Vol 18, Iss 7, p 2201 (2018)

The purpose of the present work was to design, synthesize and spectrally characterize cholesterol-anchored fluorescent oligonucleotide probes (Ch(F-TBA-T), Ch(py-TBA-py)), based on G-quadruplexes, which were able to incorporate into a lipid structure

Externí odkaz: https://doaj.org/article/46c200688af24b91bfd6de60af1bfa9d

Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside

Autor: Eliza Wyszko, Marta Orlicka-Płocka, Dorota Gurda-Wozna, Agnieszka Fedoruk-Wyszomirska

Publikováno v: Apoptosis

Small-molecule compound-based therapies have provided new insights into cancer treatment against mitochondrial impairment. N6-furfuryladenosine (kinetin riboside, KR) is a purine derivative and an anticancer agent that selectively affects the molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906a8267476ed44da592ffb3caf9de47
http://europepmc.org/articles/PMC7679298

Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents

Autor: Małgorzata Giel-Pietraszuk, Agnieszka B. Olejniczak, Wojciech Rypniewski, Marta Orlicka-Płocka, Eliza Wyszko, Agnieszka Kiliszek, Agnieszka Fedoruk-Wyszomirska, Andrzej Bak, Dorota Gurda-Woźna, Aleksandra Kowalczyk, Sebastian Rykowski, Paweł Stączek

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2772, p 2772 (2021)
International journal of molecular sciences 22(5), 2772 (2021). doi:10.3390/ijms22052772

International journal of molecular sciences 22(5), 2772 (2021). doi:10.3390/ijms22052772
We synthesized a series of novel 3-carboranyl-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, using click chemistry, reductive amination and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b533d9e3e5b43aaf030b4d91d823aeea