Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Agnieszka Dreas"'
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 11, Pp o2850-o2850 (2010)
The absolute configuration of the title compound, C20H23NO2, has been confirmed as 4S. The benzyl residue and H atom at the asymmetric C-atom centre occupy pseudo-axial and bisectional positions, respectively. The oxazolidine ring adopts an envelope
Externí odkaz:
https://doaj.org/article/d41c0bbc79a340f590cca6b1b3b6b0e4
Autor:
Urszula Wojcik-Trechcinska, Magdalena Masiejczyk, Agnieszka Dreas, Zuzanna Sandowska-Markiewicz, Michal Mikula, Jerzy Ostrowski, Katarzyna Kucwaj-Brysz, Karolina Pyziak, Ewelina Wincza, Mariusz Milik, Eliza Majewska, Tomasz Rzymski, Urszula Kulesza, Aniela Golas, Krzysztof Brzózka, Charles-Henry Fabritius, Kinga Michalik, Ewelina Gabor-Worwa, Kazimiera Pyśniak
The mitogen-activated protein kinase (MAPK)-interacting kinases 1 and 2 (MNKs 1/2) and their downstream target eIF4E, play a role in oncogenic transformation, progression and metastasis. These results provided rationale for development of first MNKs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257d9bec5056ffc8190e1768581a2973
https://ruj.uj.edu.pl/xmlui/handle/item/290102
https://ruj.uj.edu.pl/xmlui/handle/item/290102
Autor:
Łukasz Sapała, Ewelina Gabor-Worwa, Adam Radzimierski, Krzysztof Goryca, Anna Wrobel, Magdalena Masiejczyk, Katarzyna Kucwaj, Aleksandra Cabaj, Małgorzata Szajewska-Skuta, Maciej Mikulski, Eliza Żyłkiewicz, Michal Combik, Jerzy Ostrowski, Izabela Dolata, Agnieszka Dreas, Jakub Woyciechowski, Krzysztof Brzózka, Urszula Kuklinska, Renata Windak, Malgorzata Statkiewicz, Aleksandra Grochowska, Michal Mikula, Arkadiusz Białas, Katarzyna Wojcik, Katarzyna Wiklik, Agata Kitlińska, Tomasz Rzymski, Aniela Golas
Publikováno v:
Oncotarget
// Tomasz Rzymski 1, * , Michal Mikula 2, * , Eliza Żylkiewicz 1 , Agnieszka Dreas 1 , Katarzyna Wiklik 1 , Aniela Golas 1 , Katarzyna Wojcik 1 , Magdalena Masiejczyk 1 , Anna Wrobel 1 , Izabela Dolata 1 , Agata Kitlinska 1 , Malgorzata Statkiewicz
Autor:
Ewelina Rutkowska, Maria Vilenchik, Michael Frid, Agnieszka Szamborska-Gbur, Agnieszka Dreas, Marcin Król, Mariusz Milik, Krzysztof Brzózka
Publikováno v:
Journal of Molecular Modeling. 25
DYRK1B protein kinase is an emerging anticancer target due to its overexpression in a variety of cancers and its role in cancer chemoresistance through maintaining cancer cells in the G0 (quiescent) state. Consequently, there is a growing interest in
Autor:
Jose Alvarez, Agnieszka Dreas, Kamila Kozłowska, Kinga Michalik, Magdalena Zastawna, Anna Wrobel, Karol Zuchowicz, Andrzej Mazan, Peter Littlewood, Justyna Martyka, Magdalena Łośko, Tomasz Rzymski, Agnieszka Sroka-Porada, Paulina Niedziejko, Urszula Kulesza, Luigi Stasi, Joanna Szczęśniak, Krzysztof Brzózka, Adam Radzimierski, Katarzyna Wnuk-Lipinska, Katarzyna Wiklik, Anna Kowal
Publikováno v:
Cancer Research. 80:3656-3656
Background: Synthetic lethality is one of the most innovative approaches for selective targeting of cancer cells with defined genetic background. SMARCA2 and SMARCA4 are two mutually exclusive helicase/ATPase catalytic subunits belonging to SWI/SNF c
Autor:
Christophe Goncalves, Yutian Cai, Eliza Żyłkiewicz, Fan Huang, Fabrice Journe, Maciej Mikulski, Jie Su, Moulay A. Alaoui-Jamali, Sidong Huang, Jun Guo, Tomasz Rzymski, Qianyu Guo, Yao Zhan, Yan Kong, Sonia V. del Rincón, Wilson H. Miller, William Yang, Bonnie Huor, Agnieszka Dreas, Ivan Topisirovic, Sabrina Daniela da Silva, Krzysztof Brzózka, Krikor Bijian, Aniela Golas, Meng Ma, Jose Torres, Ghanem Elias Ghanem
Publikováno v:
The Journal of clinical investigation. 127(11)
Melanoma can be stratified into unique subtypes based on distinct pathologies. The acral/mucosal melanoma subtype is characterized by aberrant and constitutive activation of the proto-oncogene receptor tyrosine kinase C-KIT, which drives tumorigenesi
Publikováno v:
HETEROCYCLES. 99:1073
Autor:
Agnieszka Dreas, Krzysztof Brzózka, Tomasz Rzymski, Charles-Henry Fabritius, Mariusz Milik, Maciej Mikulski
Publikováno v:
Current medicinal chemistry. 24(28)
MAP kinase-interacting kinases (MNK1 and MNK2) are often activated downstream of ERK and p38 MAPK in the MAP kinase family. The role of MNKs in the development and progression of solid tumors and hematological malignancies has been widely discussed,
Autor:
Jerzy Ostrowski, Milena Mazan, Katarzyna Wojcik, Michal Combik, Magdalena Masiejczyk, Agnieszka Dreas, Katarzyna Wiklik, Krzysztof Brzózka, Michal Mikula, Urszula Kuklinska, Aniela Golas, Tomasz Rzymski, Eliza Majewska, Malgorzata Statkiewicz, Aleksandra Grochowska, Krzysztof Goryca, Aleksandra Cabaj
Publikováno v:
Cancer Research. 78:5829-5829
Despite heterogeneity deregulated transcription is one of the universal features of leukemia cells. This has paved the way for the development of active compounds targeting epigenetic and transcriptional factors. A substituted tricyclic benzimidazole
Autor:
Agnieszka Przybylowicz, Marta Sowinska, Krzysztof Brzózka, Agnieszka Adamus, Pawel Guzik, Marcin Król, Urszula Kulesza, Przemyslaw Golik, Mateusz Nowak, Tomasz Rzymski, Karolina Gluza, Justyna Wujkowska, Nicolas Boutard, Piotr Kowalczyk, Magdalena Sieprawska-Lupa, David J. Schultz, Anna Wrobel, Karolina Pyziak, Agnieszka Sroka-Porada, Magdalena Zastawna, Anna Bartosik, Agnieszka Dreas, Faustyna Iwanska
Publikováno v:
Cancer Research. 78:3516-3516
Over-activation of the serine synthesis pathway, upregulation of SHMT2 has been described in over 20% of solid tumors (e.g. breast, lung, colorectal cancers). Such cancer cells are highly dependent on serine. Serine hydroxymethyltransferase (SHMT) pl