Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Agnieszka Sulima"'
Autor:
Hudson G. Roth, Madhurima Das, Agnieszka Sulima, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 29, Iss 9, p 1926 (2024)
The synthesis of stereochemically pure oximes, amines, saturated and unsaturated cyanomethyl compounds, and methylaminomethyl compounds at the C9 position in 3-hydroxy-N-phenethyl-5-phenylmorphans provided μ-opioid receptor (MOR) agonists with varie
Externí odkaz:
https://doaj.org/article/ffafaa3d32ea40d5bd3043c657d40a47
Autor:
Robert W. Seaman, Kariann Lamon, Nicholas Whitton, Brian Latimer, Agnieszka Sulima, Kenner C. Rice, Kevin S. Murnane, Gregory T. Collins
Publikováno v:
Brain Sciences, Vol 14, Iss 3, p 258 (2024)
Recent data suggest that 3,4-methylenedioxypyrovalerone (MDPV) has neurotoxic effects; however, the cognitive and neurochemical consequences of MDPV self-administration remain largely unexplored. Furthermore, despite the fact that drug preparations t
Externí odkaz:
https://doaj.org/article/e97d2a6a879949308a5852f1a660f32f
Autor:
Edna J. Santos, Nima Nassehi, Eric W. Bow, Dana R. Chambers, Eugene S. Gutman, Arthur E. Jacobson, Joshua A. Lutz, Samuel A. Marsh, Kenner C. Rice, Agnieszka Sulima, Dana E. Selley, S. Stevens Negus
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 4, Pp n/a-n/a (2023)
Abstract Low‐efficacy mu‐opioid receptor (MOR) agonists represent promising therapeutics, but existing compounds (e.g., buprenorphine, nalbuphine) span a limited range of low MOR efficacies and have poor MOR selectivity. Accordingly, new and sele
Externí odkaz:
https://doaj.org/article/3416c03aeec64d3f8a90e94380e1ee04
Autor:
Madhurima Das, George W. Ward, Agnieszka Sulima, Dan Luo, Thomas Edward Prisinzano, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 28, Iss 23, p 7709 (2023)
(−)-5,9-Dimethyl-6,7-benzomorphan (normetazocine) derivatives with a para-OH or ortho-F substituent in the aromatic ring of the N-phenethyl moiety were synthesized and found to have subnanomolar potency at MOR, and both were fully efficacious in vi
Externí odkaz:
https://doaj.org/article/9bbb663c8248404c9ee45202cb61671a
Publikováno v:
Brain Sciences, Vol 13, Iss 9, p 1294 (2023)
Background: As individual synthetic cathinones become scheduled and regulated by the Drug Enforcement Administration (DEA), new ones regularly are produced and distributed. One such compound is eutylone, a novel third-generation synthetic cathinone w
Externí odkaz:
https://doaj.org/article/c4ec772c09e746b9a4117410ce1fa241
Autor:
Dana R. Chambers, Agnieszka Sulima, Dan Luo, Thomas E. Prisinzano, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 28, Iss 14, p 5411 (2023)
The 5-(3-hydroxy)phenylmorphan structural class of compounds are unlike the classical morphinans, 4,5-epoxymorphinans, and 6,7-benzomorphans, in that they have an equatorially oriented aromatic ring rather than the axial orientation of that ring foun
Externí odkaz:
https://doaj.org/article/1173e73197ae44f09a580ac3675e041b
Autor:
Joshua A. Lutz, Agnieszka Sulima, Eugene S. Gutman, Eric W. Bow, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Carol A. Paronis, Jack Bergman, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 28, Iss 12, p 4795 (2023)
All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists. These compou
Externí odkaz:
https://doaj.org/article/d4aecd3b74884423a75e5b6fc1efb0c0
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100390- (2022)
Two modifications of previous procedures enabled the high-yield scalable synthesis of the pharmacologically important enantiomers of a C9-keto-5-phenylmorphan ((1R,5R)- and (1S,5S)-5-(3-methoxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonan-9-one). The use
Externí odkaz:
https://doaj.org/article/73dd035c57744f8aaacb06c43321a873
Autor:
Dana R. Chambers, Agnieszka Sulima, Dan Luo, Thomas E. Prisinzano, Alexander Goldberg, Bing Xie, Lei Shi, Carol A. Paronis, Jack Bergman, Nima Nassehi, Dana E. Selley, Gregory H. Imler, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 27, Iss 19, p 6455 (2022)
Four sets of diastereomeric C9-alkenyl 5-phenylmorphans, varying in the length of the C9-alkenyl chain, were designed to examine the effect of these spatially distinct ligands on opioid receptors. Functional activity was obtained by forskolin-induced
Externí odkaz:
https://doaj.org/article/d9c38bdcc69f493eb1644c1632588662
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Externí odkaz:
https://doaj.org/article/bf0ef294fd8c438daf1a9c689c3763b3