Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Agnieszka Śliwińska"'
Autor:
Łukasz Biegała, Arkadiusz Gajek, Izabela Szymczak-Pajor, Agnieszka Marczak, Agnieszka Śliwińska, Aneta Rogalska
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Olaparib is a PARP inhibitor (PARPi) approved for targeted treatment of ovarian cancer (OC). However, its efficacy is impeded by the inevitable occurrence of resistance. Here, we investigated whether the cytotoxic activity of olaparib could
Externí odkaz:
https://doaj.org/article/5d528c4e2ec64cd3ac0e14eaf25d74c5
Autor:
Oskar Przybyszewski, Michał Mik, Michał Nowicki, Michał Kusiński, Melania Mikołajczyk-Solińska, Agnieszka Śliwińska
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1713 (2024)
Pancreatic cancer is a severe disease, challenging to diagnose and treat, and thereby characterized by a poor prognosis and a high mortality rate. Pancreatic ductal adenocarcinoma (PDAC) represents approximately 90% of pancreatic cancer cases, while
Externí odkaz:
https://doaj.org/article/ebdafa1772d64b3795b343f6cfe9b639
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 898 (2024)
Metformin, one of the most frequently used oral glucose-lowering drugs (GLDs), is associated with the occurrence of gastrointestinal (GI) adverse events in approximately 20% of users. These unwanted actions result in non-compliance or even discontinu
Externí odkaz:
https://doaj.org/article/764427d377144d47b62e406c32b23e6c
Autor:
Łukasz Biegała, Damian Kołat, Arkadiusz Gajek, Elżbieta Płuciennik, Agnieszka Marczak, Agnieszka Śliwińska, Michał Mikula, Aneta Rogalska
Publikováno v:
Cells, Vol 13, Iss 10, p 867 (2024)
Resistance to olaparib is the major obstacle in targeted therapy for ovarian cancer (OC) with poly(ADP-ribose) polymerase inhibitors (PARPis), prompting studies on novel combination therapies to enhance olaparib efficacy. Despite identifying various
Externí odkaz:
https://doaj.org/article/1d9e54b2388e4f19acec0a16926dc92b
Publikováno v:
Cells, Vol 12, Iss 18, p 2228 (2023)
Background: It is well known that oxidative stress plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). It has been suggested that an insufficient antioxidant defense system composed of antioxidant enzymes, includi
Externí odkaz:
https://doaj.org/article/36a9e35b2f794b9286a04e736ac40230
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1097 (2023)
In clinical practice, we often deal with patients who suffer from non-alcoholic fatty liver disease (NAFLD) concurrent with type 2 diabetes mellitus (T2DM). The etiopathogenesis of NAFLD is mainly connected with insulin resistance (IR) and obesity. S
Externí odkaz:
https://doaj.org/article/bf71850379c8450986e1b5faae16d08a
Autor:
Izabela Szymczak-Pajor, Józef Drzewoski, Ewa Świderska, Justyna Strycharz, Anna Gabryanczyk, Jacek Kasznicki, Marta Bogdańska, Agnieszka Śliwińska
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 115 (2023)
Accumulating evidence (mainly from experimental research) suggests that metformin possesses anticancer properties through the induction of apoptosis and inhibition of the growth and proliferation of cancer cells. However, its effect on the enzymes re
Externí odkaz:
https://doaj.org/article/9bb8afdd0bb543209d563f005c79013f
Autor:
Marcin Kosmalski, Józef Drzewoski, Izabela Szymczak-Pajor, Andrzej Zieleniak, Melania Mikołajczyk-Solińska, Jacek Kasznicki, Agnieszka Śliwińska
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2253 (2022)
Irisin is a cytokine involved in many metabolic pathways occurring, among others, in muscles, adipose tissue and liver. Thus, fluctuations in irisin levels are suggested to be related to metabolic diseases. Therefore, the purpose of our study was to
Externí odkaz:
https://doaj.org/article/7fff2d9bc9fb42ee8a9b8c24e3adf1eb
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1087 (2022)
Prolonged elevated oxidative stress (OS) possesses negative effect on cell structure and functioning, and is associated with the development of numerous disorders. Naturally occurred anti-oxidant compounds reduce the oxidative stress in living organi
Externí odkaz:
https://doaj.org/article/b357114b1f504712acd3c073d28bf12e
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 810 (2022)
Metformin, a cheap and safe biguanide derivative, due to its ability to influence metabolism, is widely used as a first-line drug for type 2 diabetes (T2DM) treatment. Therefore, the aim of this review was to present the updated biochemical and molec
Externí odkaz:
https://doaj.org/article/c422e0e22c3f4a0fa63024b0389ac7b8