Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Agnieszka, Wróbel"'
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1079 (2024)
Human dihydrofolate reductase (hDHFR) is an essential cellular enzyme, and inhibiting its activity is a promising strategy for cancer therapy. We have chosen the trimethoprim molecule (TMP) as a model compound in our search for a new class of hDHFR i
Externí odkaz:
https://doaj.org/article/3acb67ff12de46b596d8de0672097109
Autor:
Joanna Stolarek (ed.), Jarosław Wiliński (ed.), Judit Baranyiné Kóczy, Iwona Filipczak, Anna Gaidash, Oleksandr Kapranov, Joanna Stolarek, Michaela Weiss, Jarosław Wiliński, Anna Wortman, Agnieszka Wróbel
This volume on Cross-Cultural Perspectives in Literature and Language provides an international forum for the exchange of ideas related to multiculturalism; multi-ethicity; cross-cultural perspectives in literature, the arts, and politics; integratio
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14901 (2023)
The synthesis of eleven new and previously undescribed benzamides was designed. These compounds were specifically projected as potential inhibitors of the enzymes acetylcholinesterase (AChE) and β-secretase (BACE1). N,N′-(1,4-phenylene)bis(3-metho
Externí odkaz:
https://doaj.org/article/46d502cb2934493eb8f902978b459ba8
Autor:
Dawid Maliszewski, Rasime Demirel, Agnieszka Wróbel, Maciej Baradyn, Artur Ratkiewicz, Danuta Drozdowska
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1248 (2023)
The spectrum of biological properties of s-triazine derivatives is broad and includes anti-microbial, anti-cancer, and anti-neurodegenerative activities, among others. The s-triazine molecule, due to the possibility of substituting three substituents
Externí odkaz:
https://doaj.org/article/3053dc79ae90447e8422bc563b12184a
Autor:
Agnieszka Wróbel-Chmiel
Publikováno v:
Probacja, Vol 3, Pp 29-49 (2018)
The aim of the article is to discuss the issue of hardships of prison isolation experienced by perpetrators of murder serving long-term custodial sentences. In the first section of the article, dealing with theory, the author describes difficult situ
Externí odkaz:
https://doaj.org/article/17eccc28e12948e491c60ec628d3c6c3
Publikováno v:
Polish Journal of Social Rehabilitation, Vol 2018, Iss 15, Pp 129-142 (2018)
The article analyses parental attitudes of mothers and fathers serving prison sentences. A comparison was made between the attitudes of 50 women and 50 men, parents of minor children up to the age of 18, who had been raising them up before they were
Externí odkaz:
https://doaj.org/article/91c58d34c86b430dbe68e46e5d27aae0
Publikováno v:
Molecules, Vol 26, Iss 13, p 3942 (2021)
A series of new analogs of nitrogen mustards (4a–4h) containing the 1,3,5-triazine ring substituted with dipeptide residue were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and β-secretase (BACE1) enzymes. The A
Externí odkaz:
https://doaj.org/article/4f0f54f1c0fc4bbc87c9f3f33a1e02f1
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3685 (2021)
Eighteen previously undescribed trimethoprim (TMP) analogs containing amide bonds (1–18) were synthesized and compared with TMP, methotrexate (MTX), and netropsin (NT). These compounds were designed as potential minor groove binding agents (MGBAs)
Externí odkaz:
https://doaj.org/article/2a38aca259464f39a78d34c58dc98010
Publikováno v:
Molecules, Vol 25, Iss 1, p 116 (2019)
A new series of trimethoprim (TMP) analogs containing amide bonds (1−6) have been synthesized. Molecular docking, as well as dihydrofolate reductase (DHFR) inhibition assay were used to confirm their affinity to bind dihydrofolate reductase enzyme.
Externí odkaz:
https://doaj.org/article/cad5a05e30ce43c49ce0e2fbdb94fe9b
Autor:
Agnieszka Wróbel, Danuta Drozdowska
Publikováno v:
Current Medicinal Chemistry. 28:910-939
Background: Dihydrofolate reductase (DHFR) has been known for decades as a molecular target for antibacterial, antifungal and anti-malarial treatments. This enzyme is becoming increasingly important in the design of new anticancer drugs, which is con