Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Agnieszka, Kubat"'
Autor:
Giorgio, Ottaviano, Christos, Georgiadis, Soragia Athina, Gkazi, Farhatullah, Syed, Hong, Zhan, Annie, Etuk, Roland, Preece, Jan, Chu, Agnieszka, Kubat, Stuart, Adams, Paul, Veys, Ajay, Vora, Kanchan, Rao, Waseem, Qasim, Daesik, Kim
Publikováno v:
Science translational medicine. 14(668)
Genome editing of allogeneic T cells can provide “off-the-shelf” alternatives to autologous chimeric antigen receptor (CAR) T cell therapies. Disruption of T cell receptor α chain (TRAC) to prevent graft-versus-host disease (GVHD) and removal of
Autor:
Robert Chiesa, Christos Georgiadis, Giorgio Ottaviano, Farhatullah Syed, Toni Braybrook, Annie Etuk, Hong Zhan, Soragia Athina Gkazi, Roland Preece, Stuart Adams, Rebecca Thomas, Arnold Awuah, Kimberly Gilmour, Lana Mhaldien, Jan Chu, Danielle Pinner, Agnieszka Kubat, Paul Veys, Kanchan Rao, Giovanna Lucchini, David O'Connor, Ajay Vora, Waseem Qasim
Publikováno v:
Blood. 140:4579-4580
Autor:
Danielle Pinner, Farhatullah Syed, Christos Georgiadis, Paul Veys, Sarah Inglott, Agnieszka Kubat, Annie Etuk, Ajay Vora, Giorgio Ottaviano, Stuart Adams, Susanne Kricke, Kanchan Rao, Waseem Qasim, Soragia Athina Gkazi, Dariusz Ladon, Kimberly Gilmour, Natalia Izotova, Hong Zhan, Jan Chu
Publikováno v:
Blood. 138:4838-4838
Background 'Off-the-shelf' CAR T cell therapies are being investigated as alternatives to autologous CAR therapy, and can be generated using genome editing from allogeneic donors. Strategies to address HLA barriers include disruption of T cell recept