Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Agnieszka, Bzowska"'
Autor:
Marta Ilona Wojtyś, Weronika Maksymiuk, Marta Narczyk, Ante Bubić, Ivana Leščić Ašler, Paweł Krzyżek, Grażyna Gościniak, Elżbieta Katarzyna Jagusztyn-Krynicka, Agnieszka Bzowska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
The current therapies against gastric pathogen Helicobacter pylori are ineffective in over 20% of patients. Enzymes belonging to the purine salvage pathway are considered as novel drug targets in this pathogen. Therefore, the main aim of the current
Externí odkaz:
https://doaj.org/article/d49a28023d5d4282a32dff07929d534e
Autor:
Marta Narczyk, Marta Ilona Wojtyś, Ivana Leščić Ašler, Biserka Žinić, Marija Luić, Elżbieta Katarzyna Jagusztyn-Krynicka, Zoran Štefanić, Agnieszka Bzowska
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1083-1097 (2022)
Helicobacter pylori represents a global health threat with around 50% of the world population infected. Due to the increasing number of antibiotic-resistant strains, new strategies for eradication of H. pylori are needed. In this study, we suggest pu
Externí odkaz:
https://doaj.org/article/b8e2c6ef5de44b0fb211f30cc3691fae
Autor:
Marta Narczyk, Łukasz Mioduszewski, Aleksandra Oksiejuk, Maria Winiewska-Szajewska, Beata Wielgus-Kutrowska, Adrian Gojdź, Joanna Cieśla, Agnieszka Bzowska
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract E. coli purine nucleoside phosphorylase is a homohexamer, which structure, in the apo form, can be described as a trimer of dimers. Earlier studies suggested that ligand binding and kinetic properties are well described by two binding consta
Externí odkaz:
https://doaj.org/article/496f274ca99b4a1f857d7a1fc80b317d
Autor:
Ante Bubić, Marta Narczyk, Ana Petek, Marta Ilona Wojtyś, Weronika Maksymiuk, Beata Wielgus-Kutrowska, Maria Winiewska-Szajewska, Tea Pavkov-Keller, Branimir Bertoša, Zoran Štefanić, Marija Luić, Agnieszka Bzowska, Ivana Leščić Ašler
Publikováno v:
International Journal of Biological Macromolecules. 226:37-50
Purine nucleotide synthesis is realised only through the salvage pathway in pathogenic bacterium Helicobacter pylori. Therefore, the enzymes of this pathway, among them also the adenylosuccinate synthetase (AdSS), present potential new drug targets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a08c448faeb8e035a12494a0af5dc71
https://doi.org/10.1016/j.ijbiomac.2022.12.001
https://doi.org/10.1016/j.ijbiomac.2022.12.001
Autor:
Ante Bubić, Natalia Mrnjavac, Igor Stuparević, Marta Łyczek, Beata Wielgus-Kutrowska, Agnieszka Bzowska, Marija Luić, Ivana Leščić Ašler
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1405-1414 (2018)
Adenylosuccinate synthetase (AdSS) is an enzyme at regulatory point of purine metabolism. In pathogenic organisms which utilise only the purine salvage pathway, AdSS asserts itself as a promising drug target. One of these organisms is Helicobacter py
Externí odkaz:
https://doaj.org/article/bf04bc0ee087458183a4240bb0f2d5af
Autor:
Urszula Zarzecka, Anna Modrak-Wójcik, Donata Figaj, Malgorzata Apanowicz, Adam Lesner, Agnieszka Bzowska, Barbara Lipinska, Anna Zawilak-Pawlik, Steffen Backert, Joanna Skorko-Glonek
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
The protease high temperature requirement A from the gastric pathogen Helicobacter pylori (HtrAHp) belongs to the well conserved family of serine proteases. HtrAHp is an important secreted virulence factor involved in the disruption of tight and adhe
Externí odkaz:
https://doaj.org/article/366893ad318d464e97cc12623c9a4e21
Autor:
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Michał Górka, Agnieszka Bzowska, Ryszard Stolarski, Beata Wielgus-Kutrowska
Publikováno v:
Molecules, Vol 25, Iss 3, p 681 (2020)
Etheno-derivatives of 2-aminopurine, 2-aminopurine riboside, and 7-deazaadenosine (tubercidine) were prepared and purified using standard methods. 2-Aminopurine reacted with aqueous chloroacetaldehyde to give two products, both exhibiting substrate a
Externí odkaz:
https://doaj.org/article/072e0c6dd84c4c2eaed667b947d6dd33
Autor:
Alicja Dyzma, Beata Wielgus-Kutrowska, Agnieszka Girstun, Zoe Jelić Matošević, Krzysztof Staroń, Branimir Bertoša, Joanna Trylska, Agnieszka Bzowska
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2157
Volume 24
Issue 3
Pages: 2157
Mammalian purine nucleoside phosphorylase (PNP) is biologically active as a homotrimer, in which each monomer catalyzes a reaction independently of the others. To answer the question of why the native PNP forms a trimeric structure, we constructed, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f31e10c7f165b5fc167c8b55c3b257a
Autor:
Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Michał Górka, Agnieszka Bzowska, Beata Wielgus-Kutrowska
Publikováno v:
Molecules, Vol 24, Iss 8, p 1493 (2019)
Etheno-derivatives of guanine, O6-methylguanine, and isoguanine were prepared and purified using standard methods. The title compounds were examined as potential substrates of purine-nucleoside phosphorylases from various sources in the reverse (synt
Externí odkaz:
https://doaj.org/article/5483bece016844be97ff1b088de7df28
Autor:
Joanna Krajewska, Anna Modrak-Wójcik, Zbigniew J Arent, Daniel Więckowski, Michal Zolkiewski, Agnieszka Bzowska, Sabina Kędzierska-Mieszkowska
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181118 (2017)
Leptospira interrogans is a spirochaete responsible for leptospirosis in mammals. The molecular mechanisms of the Leptospira virulence remain mostly unknown. Recently, it has been demonstrated that an AAA+ chaperone ClpB (a member of the Hsp100 famil
Externí odkaz:
https://doaj.org/article/9574c7386c2d4350b1bf7d0700c656ce