Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Agnieszka, Łoboda"'
Autor:
Olga Mucha, Paulina Podkalicka, Monika Żukowska, Ewelina Pośpiech, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Skeletal muscle regeneration relies on the reciprocal interaction between many types of cells. Regenerative capacity may be altered in different disorders. In our study, we investigated whether the deletion of miR-378a (miR-378) affects musc
Externí odkaz:
https://doaj.org/article/bb84564b4ad84804a5000fbf158dda0d
Autor:
Agnieszka Łoboda, Józef Dulak
Publikováno v:
Cells, Vol 13, Iss 2, p 158 (2024)
Hydrogen sulfide (H2S) belongs to the family of gasotransmitters and can modulate a myriad of biological signaling pathways. Among others, its cardioprotective effects, through antioxidant, anti-inflammatory, anti-fibrotic, and proangiogenic activiti
Externí odkaz:
https://doaj.org/article/785f69969ced42ea97dc25f43a6ddab0
Autor:
Olga Mucha, Małgorzata Myszka, Paulina Podkalicka, Bianka Świderska, Agata Malinowska, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1648 (2023)
Mdx mice with a spontaneous mutation in exon 23 of the Dmd gene represent the most common model to investigate the pathophysiology of Duchenne muscular dystrophy (DMD). The disease, caused by the lack of functional dystrophin, is characterized by irr
Externí odkaz:
https://doaj.org/article/b5a527238d524efe87466f14c2ea7a38
Autor:
Paulina Podkalicka, Olga Mucha, Katarzyna Kaziród, Krzysztof Szade, Jacek Stępniewski, Liudmyla Ivanishchuk, Hirofumi Hirao, Ewelina Pośpiech, Alicja Józkowicz, Jerzy W. Kupiec-Weglinski, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Although Duchenne muscular dystrophy (DMD) primarily affects muscle tissues, the alterations to systemic metabolism manifested in DMD patients contribute to the severe phenotype of this fatal disorder. We propose that microRNA-378a (miR-378)
Externí odkaz:
https://doaj.org/article/31f8767de0804f9ea3cdfb34755154d9
Autor:
Olga Mucha, Paulina Podkalicka, Katarzyna Kaziród, Emilia Samborowska, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Background Duchenne muscular dystrophy (DMD) is an incurable disease, caused by the mutations in the DMD gene, encoding dystrophin, an actin-binding cytoskeletal protein. Lack of functional dystrophin results in muscle weakness, degeneration
Externí odkaz:
https://doaj.org/article/60466cde0c564a7bb16d8020398b93f5
Autor:
Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Paulina Podkalicka, Neli Kachamakova-Trojanowska, Agnieszka Łoboda, Józef Dulak
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-22 (2020)
Abstract The nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as a master cytoprotective factor regulating the expression of genes encoding anti-oxidant, anti-inflammatory, and detoxifying proteins. The role of Nrf2 in the pathophysio
Externí odkaz:
https://doaj.org/article/c5e388dcb2d7452bbec8be28b743ac40
Autor:
Aleksandra Brankiewicz, Sara Trzos, Magdalena Mrożek, Małgorzata Opydo, Elżbieta Szostak, Michał Dziurka, Monika Tuleja, Agnieszka Łoboda, Ewa Pocheć
Publikováno v:
Molecules, Vol 28, Iss 3, p 1509 (2023)
Oxidative stress and the hypoxic microenvironment play a key role in the progression of human melanoma, one of the most aggressive skin cancers. The aim of our study was to evaluate the effect of Hypericum perforatum extracts of different origins (bo
Externí odkaz:
https://doaj.org/article/fe0c7cf977e94bbcbfd10a0236176393
Autor:
Iwona Bronisz-Budzyńska, Katarzyna Chwalenia, Olga Mucha, Paulina Podkalicka, Karolina-Bukowska-Strakova, Alicja Józkowicz, Agnieszka Łoboda, Magdalena Kozakowska, Józef Dulak
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-17 (2019)
Abstract Duchenne muscular dystrophy (DMD) is a genetic disease evoked by a mutation in the dystrophin gene. It is associated with progressive muscle degeneration and increased inflammation. Up to this date, mainly anti-inflammatory treatment is avai
Externí odkaz:
https://doaj.org/article/175c5c5bbe5442d28ac094fd7588e154
Autor:
Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Katarzyna Pietraszek-Gremplewicz, Magdalena Madej, Alicja Józkowicz, Agnieszka Łoboda, Józef Dulak
Publikováno v:
Cells, Vol 11, Iss 20, p 3321 (2022)
Increased oxidative stress can slow down the regeneration of skeletal muscle and affect the activity of muscle satellite cells (mSCs). Therefore, we evaluated the role of the NRF2 transcription factor (encoded by the Nfe2l2 gene), the main regulator
Externí odkaz:
https://doaj.org/article/dad9ac307438475ca3f64aca55f2b834
Autor:
Urszula Głowniak-Kwitek, Asier Laria Caballero, Iwona Bronisz-Budzyńska, Magdalena Kozakowska, Kalina Andrysiak, Jacek Stępniewski, Agnieszka Łoboda, Józef Dulak
Publikováno v:
Pharmacological Reports. 75:397-410
Background Impaired muscle regeneration is a hallmark of Duchenne muscular dystrophy (DMD), a neuromuscular disorder caused by mutations in the DMD gene encoding dystrophin. The lack of heme oxygenase-1 (HO-1, Hmox1), a known anti-inflammatory and cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7532224e3ab3185a4018117459f8d677
https://doi.org/10.1007/s43440-023-00475-3
https://doi.org/10.1007/s43440-023-00475-3