Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Agnete Kirkeby"'
Autor:
Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell, Agnete Kirkeby
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Background Ventral midbrain (VM) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical development for treatment
Externí odkaz:
https://doaj.org/article/bdabac730d1e4a36a7e6eb8d2f0a4e71
Autor:
Meeli Mullari, Nicolas Fossat, Niels H. Skotte, Andrea Asenjo-Martinez, David T. Humphreys, Jens Bukh, Agnete Kirkeby, Troels K. H. Scheel, Michael L. Nielsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract RNA-binding proteins (RBPs) are key players regulating RNA processing and are associated with disorders ranging from cancer to neurodegeneration. Here, we present a proteomics workflow for large-scale identification of RBPs and their RNA-bin
Externí odkaz:
https://doaj.org/article/af7bee72a0c145a5ad5d646db7ed76f4
Autor:
Raquel Garza, Yogita Sharma, Diahann A.M. Atacho, Arun Thiruvalluvan, Sami Abu Hamdeh, Marie E. Jönsson, Vivien Horvath, Anita Adami, Martin Ingelsson, Patric Jern, Molly Gale Hammell, Elisabet Englund, Agnete Kirkeby, Johan Jakobsson, Niklas Marklund
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113395- (2023)
Summary: Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-s
Externí odkaz:
https://doaj.org/article/2182cd57962a40b49e0e6df1e118e7c8
Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-20 (2022)
Abstract Schizophrenia (SZ) is a severe psychiatric disorder, with a prevalence of 1–2% world-wide and substantial health- and social care costs. The pathology is influenced by both genetic and environmental factors, however the underlying cause st
Externí odkaz:
https://doaj.org/article/799f7fcde1984dc98bf14b2f1ed66808
Autor:
Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-
Externí odkaz:
https://doaj.org/article/e42834ed181548b18cc8c7636ddae20d
Autor:
Max Brambach, Ariane Ernst, Sara Nolbrant, Janelle Drouin-Ouellet, Agnete Kirkeby, Malin Parmar, Victor Olariu
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102559- (2021)
Summary: Rostrocaudal patterning of the neural tube is a defining event in vertebrate brain development. This process is driven by morphogen gradients which specify the fate of neural progenitor cells, leading to the partitioning of the tube. Althoug
Externí odkaz:
https://doaj.org/article/dd93889126694aef8a383478af87d918
Autor:
Daniela Lehnen, Serena Barral, Tiago Cardoso, Shane Grealish, Andreas Heuer, Andrej Smiyakin, Agnete Kirkeby, Jutta Kollet, Harold Cremer, Malin Parmar, Andreas Bosio, Sebastian Knöbel
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1207-1220 (2017)
Human pluripotent stem cell (hPSC)-derived mesencephalic dopaminergic (mesDA) neurons can relieve motor deficits in animal models of Parkinson's disease (PD). Clinical translation of differentiation protocols requires standardization of production pr
Externí odkaz:
https://doaj.org/article/c5a2be1c0cd54e89acb7a2b580780bba
Autor:
Roksana Moraghebi, Agnete Kirkeby, Patricia Chaves, Roger E. Rönn, Ewa Sitnicka, Malin Parmar, Marcus Larsson, Andreas Herbst, Niels-Bjarne Woods
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-12 (2017)
Abstract Background Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of these cells in disease
Externí odkaz:
https://doaj.org/article/adba637cebd44013a326c5d4fffa323c
Autor:
Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/07caa5d96c2949738e0c1d2aeb44e50d
Autor:
Shane Grealish, Andreas Heuer, Tiago Cardoso, Agnete Kirkeby, Marie Jönsson, Jenny Johansson, Anders Björklund, Johan Jakobsson, Malin Parmar
Publikováno v:
Stem Cell Reports, Vol 4, Iss 6, Pp 975-983 (2015)
Human embryonic stem cell (hESC)-derived dopamine neurons are currently moving toward clinical use for Parkinson’s disease (PD). However, the timing and extent at which stem cell-derived neurons functionally integrate into existing host neural circ
Externí odkaz:
https://doaj.org/article/d1fe52c7ede24adf9d902ffe2fc73a53