Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig

Autor: Janus H. Magnussen, Anders Ettrup, Szabolcs Lehel, Dan Peters, Agnete Dyssegaard, Morten S. Thomsen, Jens D. Mikkelsen, Gitte M. Knudsen

Publikováno v: Frontiers in Neuroimaging, Vol 3 (2024)

The alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's disea

Externí odkaz: https://doaj.org/article/8e3fcf4ca7914f3da7f774cded81f30c

Characterization of the serotonin 2A receptor selective PET tracer (R)-[18F]MH.MZ in the human brain

Autor: Vasko Kramer, Frank Rösch, Horacio Amaral, Agnete Dyssegaard, Cristian Soza-Ried, Jonathan Flores, Matthias M. Herth, Gitte M. Knudsen

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 47:355-365

The serotonin receptor subtype 2A antagonist (5-HT2AR) (R)-[18F]MH.MZ has in preclinical studies been identified as a promising PET imaging agent for quantification of cerebral 5-HT2ARs. It displays a very similar selectivity profile as [11C]MDL 1009

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f91655b3e9649f16e1275030a70cdd2
https://doi.org/10.1007/s00259-019-04527-w

Measuring endogenous changes in serotonergic neurotransmission with [11C]Cimbi-36 positron emission tomography in humans

Autor: Kirsten Møller, Louise Møller Jørgensen, Anine Persson Skibsted, Gitte M. Knudsen, Brenda Mc Mahon, Szabolcs Lehel, Nic Gillings, Claus Svarer, Anders Ettrup, Agnete Dyssegaard, Sofi da Cunha-Bang, Martin Schain

Publikováno v: Translational Psychiatry, Vol 9, Iss 1, Pp 1-10 (2019)
Translational Psychiatry
da Cunha-Bang, S, Ettrup, A, Mc Mahon, B, Skibsted, A P, Schain, M, Lehel, S, Dyssegaard, A, Jørgensen, L M, Møller, K, Gillings, N, Svarer, C & Knudsen, G M 2019, ' Measuring endogenous changes in serotonergic neurotransmission with [11C]Cimbi-36 positron emission tomography in humans ', Translational Psychiatry, vol. 9, no. 1, 134 . https://doi.org/10.1038/s41398-019-0468-8

Developing positron emission tomography (PET) radioligands for the detection of endogenous serotonin release will enable the investigation of serotonergic deficits in many neuropsychiatric disorders. The present study investigates how acute challenge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808c7371530273cc0952f809d6051585
http://link.springer.com/article/10.1038/s41398-019-0468-8

Evaluation of [18 F]2FP3 in pigs and non-human primates

Autor: Luc Zimmer, Janus H. Magnussen, Gilles Tamagnan, Matthias M. Herth, Olivier Barret, Agnete Dyssegaard, Szabolcs Lehel, Cristian Constantinescu, Thierry Billard, Gitte M. Knudsen, Julie Colomb, Hanne D. Hansen

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals
Journal of Labelled Compounds and Radiopharmaceuticals, Wiley-Blackwell, 2019, 62 (1), pp.34-42. ⟨10.1002/jlcr.3692⟩

So far, no suitable 5-HT7 R radioligand exists for clinical positron emission tomography (PET) imaging. [18 F]2FP3 was first tested in vivo in cats, and the results were promising for further evaluations. Here, we evaluate the radioligand in pigs and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c76a97d2b787ffae64009a459f4160
https://doi.org/10.1002/jlcr.3692

The Variability of Translocator Protein Signal in Brain and Blood of Genotyped Healthy Humans Using In Vivo 123I-CLINDE SPECT Imaging: A Test–Retest Study

Autor: Carsten Thomsen, Gerda Thomsen, Kirsten Møller, Gitte M. Knudsen, Claus Svarer, Lars H. Pinborg, Per Moestrup Jensen, Agnete Dyssegaard, Jens D. Mikkelsen, Lars Vestergaard Knudsen, Denis Guilloteau, Ling Feng

Publikováno v: Journal of Nuclear Medicine. 58:989-995

123I-CLINDE is a radiotracer developed for SPECT and targets the 18-kDa translocator protein (TSPO). TSPO is upregulated in glial cells and used as a measure of neuroinflammation in a variety of central nervous system diseases. The aim of this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a51d5f0a14466eaef8dae155990753e
https://doi.org/10.2967/jnumed.116.183202