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Comparative single-cell multiplex immunophenotyping of therapy-naive patients with rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus shed light on disease-specific composition of the peripheral immune system

Autor: József Á. Balog, Ágnes Zvara, Vivien Bukovinszki, László G. Puskás, Attila Balog, Gábor J. Szebeni

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionSystemic autoimmune diseases (SADs) are a significant burden on the healthcare system. Understanding the complexity of the peripheral immunophenotype in SADs may facilitate the differential diagnosis and identification of potential therap

Externí odkaz: https://doaj.org/article/4e9b4c43adb14a7c9108e826395475da

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Akademický článek

Single-cell immunophenotyping revealed the association of CD4+ central and CD4+ effector memory T cells linking exacerbating chronic obstructive pulmonary disease and NSCLC

Autor: Nikolett Gémes, József Á. Balog, Patrícia Neuperger, Erzsébet Schlegl, Imre Barta, János Fillinger, Balázs Antus, Ágnes Zvara, Zoltán Hegedűs, Zsolt Czimmerer, Máté Manczinger, Gergő Mihály Balogh, József Tóvári, László G. Puskás, Gábor J. Szebeni

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionTobacco smoking generates airway inflammation in chronic obstructive pulmonary disease (COPD), and its involvement in the development of lung cancer is still among the leading causes of early death. Therefore, we aimed to have a better un

Externí odkaz: https://doaj.org/article/59d1e13b34fc423cb0f8e6ed54c43031

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Akademický článek

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Akademický článek

Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome

Autor: Melinda E. Tóth, Márta Sárközy, Gergő Szűcs, Brigitta Dukay, Petra Hajdu, Ágnes Zvara, László G. Puskás, Gábor J. Szebeni, Zsófia Ruppert, Csaba Csonka, Ferenc Kovács, András Kriston, Péter Horváth, Bence Kővári, Gábor Cserni, Tamás Csont, Miklós Sántha

Publikováno v: Biology of Sex Differences, Vol 13, Iss 1, Pp 1-19 (2022)

Highlights 1. Both HFD/APOB-100 males and females developed obesity and hypercholesterolemia; however, only males presented insulin resistance. Exercise training did not change these metabolic parameters significantly. 2. HFD/APOB-100 males showed ec

Externí odkaz: https://doaj.org/article/88d875391ed843879d334098e9fb2ba9

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[The transcription of the amyloid precursor protein and tryptophan 2,3-dioxygenase genes are increased by aging in the rat brain]

Autor: Sára, Kálmán, Magdolna, Pákáski, Szabina, Szucs, Dénes, Garab, Agnes, Domokos, Agnes, Zvara, László, Puskás, György, Bagdy, Dóra, Zelena, János, Kálmán

Publikováno v: Ideggyogyaszati szemle. 62(9-10)

Aging itself is considered as a major risk factor of dementia. The prevalence of the Alzheimer's disease (AD) is increasing exponentially after the age of 65 and doubles every 5 years. The major aim of our present research was to examine the effect o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a98d086577d943ca7fbef52573d10018
https://pubmed.ncbi.nlm.nih.gov/19835274

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Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage

Autor: Lilla Barna, Fruzsina R. Walter, András Harazin, Alexandra Bocsik, András Kincses, Vilmos Tubak, Katalin Jósvay, Ágnes Zvara, Patricia Campos-Bedolla, Mária A. Deli

Publikováno v: Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-13 (2020)

Abstract Background Excitotoxicity is a central pathological pathway in many neurological diseases with blood–brain barrier (BBB) dysfunction. Kainate, an exogenous excitotoxin, induces epilepsy and BBB damage in animal models, but the direct effec

Externí odkaz: https://doaj.org/article/8004acb906cf4c54a425795c5e55d59e

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Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II

Autor: Graham J. Cotton, Raymond B. Birge, Tom W. Muir, Kathrin H. Kirsch, J. Eduardo Fajardo, Agnes Zvara, Marcela Escalante

Publikováno v: Oncogene. 20(8)

The Crk II adaptor protein encodes an SH2/SH3-domain containing adaptor protein with an SH2-SH3-SH3 domain structure that transmits signals from tyrosine kinases. The two SH3 domains are separated by a 54 amino acid linker region, whose length is hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae32014e3a351615767b248bdc992a9
https://pubmed.ncbi.nlm.nih.gov/11314030

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inPOSE: A Flexible Toolbox for Chromosomal Cloning and Amplification of Bacterial Transgenes

Autor: Ranti Dev Shukla, Ágnes Zvara, Ákos Avramucz, Alona Yu. Biketova, Akos Nyerges, László G. Puskás, Tamás Fehér

Publikováno v: Microorganisms, Vol 10, Iss 2, p 236 (2022)

Cloning the genes and operons encoding heterologous functions in bacterial hosts is now almost exclusively carried out using plasmid vectors. This has multiple drawbacks, including the need for constant selection and variation in copy numbers. The ch

Externí odkaz: https://doaj.org/article/fcf5d7287c2d42708fd396b8ea17da26

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