Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity

Autor: Babette Wolf, Mateusz Piksa, Isabelle Beley, Agnes Patoux, Thierry Besson, Valerie Cordier, Bernd Voedisch, Patrick Schindler, Daniela Stöllner, Ludovic Perrot, Stephan von Gunten, Dominique Brees, Michael Kammüller

Publikováno v: Wolf, Babette; Piksa, Mateusz; Beley, Isabelle; Patoux, Agnes; Besson, Thierry; Cordier, Valerie; Voedisch, Bernd; Schindler, Patrick; Stöllner, Daniela; Perrot, Ludovic; von Gunten, Stephan; Brees, Dominique; Kammüller, Michael (2022). Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity. Immunology, 166(3), pp. 380-407. Wiley-Blackwell 10.1111/imm.13481

In this study we show that glycosylation is relevant for immune recognition of therapeutic antibodies, and that defined glycan structures can modulate immunogenicity. Concerns regarding immunogenicity arise from the high heterogeneity in glycosylatio

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https://boris.unibe.ch/169303/1/Immunology_-_2022_-_Wolf_-_Therapeutic_antibody_glycosylation_impacts_antigen_recognition_and_immunogenicity.pdf