Výsledky vyhledávání - "Agnes Mambole-Dema"

IκB Kinase 2 Regulates TPL-2 Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Direct Phosphorylation of TPL-2 Serine 400

Autor: Agnes Mambole-Dema, Huei Ting Yang, Steven C. Ley, Derek W. Abbott, Julia Janzen, Abduelhakem Ben-Addi, Nick Morrice, Thorsten Gantke, Karine Roget

Publikováno v: Molecular and Cellular Biology. 32:4684-4690

Tumor progression locus 2 (TPL-2) functions as a MEK-1/2 kinase, which is essential for Toll-like receptor 4 (TLR4) activation of extracellular signal-regulated kinase 1 and 2 (ERK-1/2) mitogen-activated protein (MAP) kinases in lipopolysaccharide (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505ebc7b9c864f4e4824f6ba1e81114f
https://doi.org/10.1128/mcb.01065-12

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IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases

Autor: Sven Kjaer, Stephen J. Smerdon, Stephen R. Martin, Christine Brender, Steven C. Ley, Abduelhakem Ben-Addi, Agnes Mambole-Dema, Julia Janzen

The MEK-1/2 kinase TPL-2 is critical for Toll-like receptor activation of the ERK-1/2 MAP kinase pathway during inflammatory responses, but it can transform cells following C-terminal truncation. IκB kinase (IKK) complex phosphorylation of the TPL-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c663a153c30647d4fb147fd55dac65f1
https://europepmc.org/articles/PMC4060680/

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