Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox- and Nrf2-independent manner.

Autor: Verena Wilhelmi, Ute Fischer, Heike Weighardt, Klaus Schulze-Osthoff, Carmen Nickel, Burkhard Stahlmecke, Thomas A J Kuhlbusch, Agnes M Scherbart, Charlotte Esser, Roel P F Schins, Catrin Albrecht

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65704 (2013)

In view of the steadily increasing use of zinc oxide nanoparticles in various industrial and consumer applications, toxicological investigations to evaluate their safety are highly justified. We have investigated mechanisms of ZnO nanoparticle-induce

Externí odkaz: https://doaj.org/article/46b48c391f7440b282f572247b23628e

Investigation of the Cytotoxic and Proinflammatory Effects of Cement Dusts in Rat Alveolar Macrophages

Autor: Petra Haberzettl, Kirsten Gerloff, Catrin Albrecht, Damien van Berlo, Agnes M. Scherbart, Hui Li, Roel P. F. Schins

Publikováno v: Chemical Research in Toxicology. 22:1548-1558

Exposure to cement dust, a specifically alkaline and irritant dust, is one of the most common occupational dust exposures worldwide. Although several adverse respiratory health effects have been associated with cement dust exposure, the evidence is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8eee9df23f3048fc86d84265560ad1
https://doi.org/10.1021/tx900046x

Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms

Autor: Christine R. Rose, Frederik-Jan van Schooten, Damien van Berlo, Julia Langer, Petra Haberzettl, Roel P. F. Schins, Agnes M. Scherbart, Alexey Bushmelev, Catrin Albrecht, Annette M. Schmidt

Publikováno v: Particle and Fibre Toxicology, 8(1):31. BioMed Central Ltd
Particle and Fibre Toxicology, Vol 8, Iss 1, p 31 (2011)
Particle and Fibre Toxicology

Inhalation of (nano)particles may lead to pulmonary inflammation. However, the precise mechanisms of particle uptake and generation of inflammatory mediators by alveolar macrophages (AM) are still poorly understood. The aim of this study was to inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6431f44771febe6aa8067316708710
https://cris.maastrichtuniversity.nl/en/publications/d9beb758-3290-475a-80fb-b3b759b22405

Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages

Autor: Bice Fubini, Catrin Albrecht, Francesca Grendene, Mara Ghiazza, Ivana Fenoglio, Gianmario Martra, Agnes M. Scherbart, Roel P. F. Schins, Francesco Turci

Publikováno v: Chemical research in toxicology. 24(1)

The mechanism of enhancement/inhibition of quartz toxicity induced by iron is still unclear. Here the amount of iron on a fibrogenic quartz (Qz) was increased by wet impregnation (Fe(NO(3))(3) 0.67 and 6.7 wt %). X-ray diffraction (XRD), XRF diffuse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9446789d417855ff208196fbcf0da4f8
https://pubmed.ncbi.nlm.nih.gov/21171611

Evaluation of cytotoxic effects and oxidative stress with hydroxyapatite dispersions of different physicochemical properties in rat NR8383 cells and primary macrophages

Autor: Roel P. F. Schins, Agnes M. Scherbart, Carola M. Braunbarth, Julia Scheel, Damien van Berlo, Catrin Albrecht

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 23(3)

Enhanced cytotoxicity and oxidative stress through reactive oxygen species (ROS) formation are discussed as relevant parameters regarding potential hazardous properties of nanomaterials. In this study, the biocompatibility of five hydroxyapatite mate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616f1bd48390ffb14f0223eec6b2966e
https://pubmed.ncbi.nlm.nih.gov/19444929