Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls.

Autor: Thijs Booiman, Ferdinand W Wit, Arginell F Girigorie, Irma Maurer, Davide De Francesco, Caroline A Sabin, Agnes M Harskamp, Maria Prins, Claudio Franceschi, Steven G Deeks, Alan Winston, Peter Reiss, Neeltje A Kootstra, Co-morBidity in Relation to Aids (COBRA) Collaboration

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0183357 (2017)

HIV-1-positive individuals on successful antiretroviral therapy (ART) are reported to have higher rates of age-associated non-communicable comorbidities (AANCCs). HIV-associated immune dysfunction has been suggested to contribute to increased AANCC r

Externí odkaz: https://doaj.org/article/7d050fbf6abe4c06b67baa612d0b5cb4

T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment

Autor: Viviana, Cobos Jiménez, Ferdinand W N M, Wit, Maaike, Joerink, Irma, Maurer, Agnes M, Harskamp, Judith, Schouten, Maria, Prins, Ester M M, van Leeuwen, Thijs, Booiman, Steven G, Deeks, Peter, Reiss, Neeltje A, Kootstra, W M C, Mulder

Publikováno v: Journal of infectious diseases, 214(2), 216-225. Oxford University Press
J Infect Dis
The Journal of Infectious Diseases, 214(2), 216-225. Oxford University Press

Background. Aging-associated noncommunicable comorbidities are more prevalent among human immunodeficiency virus type 1 (HIV)–infected individuals than among HIV-uninfected individuals. Residual HIV-related chronic immune activation and senescence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b49fbe846ec0b62c5063598d7fad373
https://pure.amc.nl/en/publications/tcell-activation-independently-associates-with-immune-senescence-in-hivinfected-recipients-of-longterm-antiretroviral-treatment(a9b6b7d1-6c35-43de-95e8-2525d1446178).html

Rising HIV-1 viral load set point at a population level coincides with a fading impact of host genetic factors on HIV-1 control

Autor: Jan M. Prins, Frank de Wolf, Luuk Gras, Radjin Steingrover, Agnes M. Harskamp, Irma Maurer, Marga M. Mangas Ruiz, Angélique B. van 't Wout, Brigitte Boeser-Nunnink, Ard van Sighem, Daniëlle van Manen, Hanneke Schuitemaker

Publikováno v: AIDS (London, England), 25(18), 2217-2226. Lippincott Williams and Wilkins

Objective: Heterozygosity for a 32 base pair deletion in the CCR5 gene (CCR5wt/Δ32) and the minor alleles of a single-nucleotide polymorphism in the HCP5 gene (rs2395029) and in the HLA-C gene region (−35HLA-C; rs9264942) has been associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca8adf9724e78a854fa70d6017384ad
https://doi.org/10.1097/qad.0b013e32834bec9c

The Presence of CXCR4-Using HIV-1 Prior to Start of Antiretroviral Therapy Is an Independent Predictor of Delayed Viral Suppression

Autor: Ard van Sighem, Kees Brinkman, Hanneke Schuitemaker, Angélique B. van 't Wout, Jan M. Prins, Neeltje A. Kootstra, Matthijs R.A. Welkers, Agnes M. Harskamp, Esther F. Gijsbers, Frank de Wolf

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 10, p e76255 (2013)
PLoS ONE, 8(10). Public Library of Science

The emergence of CXCR4-using HIV variants (X4-HIV) is associated with accelerated disease progression in the absence of antiretroviral therapy. However, the effect of X4-HIV variants on the treatment response remains unclear. Here we determined wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d491e6bb0392066cb99a1c11150634d1
https://doi.org/10.1371/journal.pone.0076255