Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Agnes Mühlenweg"'
1
A Self‐Sacrificing N ‐Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin
Autor: Roderich D. Süssmuth, Agnes Mühlenweg, Sascha Ramm, Eva Mösker, Annette Poch, Bartlomiej Krawczyk
Publikováno v: Angewandte Chemie International Edition. 56:9994-9997
Research on ribosomally synthesized and posttranslationally modified peptides (RiPPs) has led to an increasing understanding of biosynthetic mechanisms, mostly drawn from bacterial examples. In contrast, reports on RiPPs from fungal producers, apart
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b4bfbc9523903f88a220a34ae84969
https://doi.org/10.1002/anie.201703488
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2
Eine sich selbst opfernde N ‐Methyltransferase ist die Vorstufe des pilzlichen Sekundärmetaboliten Omphalotin
Autor: Eva Mösker, Sascha Ramm, Agnes Mühlenweg, Annette Poch, Bartlomiej Krawczyk, Roderich D. Süssmuth
Publikováno v: Angewandte Chemie. 129:10127-10130
Die Forschung an ribosomal synthetisierten und posttranslational modifizierten Peptiden (RiPPs) hat das Verstandnis von Biosynthesemechanismen zum Aufbau dieser Peptide weit vorangetrieben. Wahrend die meisten Beispiele fur RiPPs von Bakterien stamme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::127e1480fc4a0ced89204ab5e166d268
https://doi.org/10.1002/ange.201703488
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4
Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism
Autor: Roderich D. Süssmuth, Melanie Gonsior, Marcel Tietzmann, Saskia Rausch, Annette Poch, Agnes Mühlenweg
Publikováno v: ChemBioChem. 16:2610-2614
Feglymycin, a peptide antibiotic produced by Streptomyces sp. DSM 11171, consists mostly of nonproteinogenic phenylglycine-type amino acids. It possesses antibacterial activity against methicillin-resistant Staphylococcus aureus strains and antiviral
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f224218bf021b634ead787b75d22b3
https://doi.org/10.1002/cbic.201500432
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5
Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure–Activity Relationships
Autor: Loreley Calvet, Sabine Haag-Richter, Frederico Nardi, Peer Lukat, Patricia Vrignaud, Jean-Paul Nicolas, Jidong Zhang, Irene Kochems, Silke C. Wenzel, Mark Brönstrup, Tietgen Heiko, Michael Kurz, Laurent Debussche, Dietmar Schummer, Valerie Czepczor, Stefan Pelzer, Rolf Müller, Holger Hoffmann, Agnes Mühlenweg
Publikováno v: Angewandte Chemie International Edition. 54:15560-15564
The bengamides, sponge-derived natural products that have been characterized as inhibitors of methionine aminopeptidases (MetAPs), have been intensively investigated as anticancer compounds. We embarked on a multidisciplinary project to supply bengam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c9fd59d158210a5e3729cdf4831bbe
https://doi.org/10.1002/anie.201508277
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6
Resistance Genes of Aminocoumarin Producers: Two Type II Topoisomerase Genes Confer Resistance against Coumermycin A 1 and Clorobiocin
Autor: Shu-Ming Li, Agnes Mühlenweg, Elisabeth Schmutz, Lutz Heide
Publikováno v: Antimicrobial Agents and Chemotherapy. 47:869-877
The aminocoumarin resistance genes of the biosynthetic gene clusters of novobiocin, coumermycin A 1 , and clorobiocin were investigated. All three clusters contained a gyrB R resistance gene, coding for a gyrase B subunit. Unexpectedly, the clorobioc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44639dd3c3f15ee2b9fe7b0aead4b727
https://doi.org/10.1128/aac.47.3.869-877.2003
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7
Identification of the Novobiocin Biosynthetic Gene Cluster of Streptomyces spheroides NCIB 11891
Autor: Agnes Mühlenweg, Shu-Ming Li, Zhao-Xin Wang, Marion Steffensky, Lutz Heide
Publikováno v: Antimicrobial Agents and Chemotherapy. 44:1214-1222
The novobiocin biosynthetic gene cluster from Streptomyces spheroides NCIB 11891 was cloned by using homologous deoxynucleoside diphosphate (dNDP)-glucose 4,6-dehydratase gene fragments as probes. Double-stranded sequencing of 25.6 kb revealed the pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be0ceffb473c28da9f5ba5dea278a0c
https://doi.org/10.1128/aac.44.5.1214-1222.2000
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8
4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon : purification of a plant membrane-bound prenyltransferase
Autor: Shu-Ming Li, M. Melzer, Agnes Mühlenweg, Lutz Heide
Publikováno v: Planta. 205:407-413
Geranyldiphosphate:4-hydroxybenzoate 3-geranyltransferase is a regulatory enzyme in the biosynthesis of shikonin, a phytoalexin and pharmaceutical produced by cell cultures of Lithospermum erythrorhizon Sieb. et Zucc. In Linsmaier-Skoog medium, the a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b5c811e362ac707b2898d248ef98cd
https://doi.org/10.1007/s004250050337
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9
Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A
Autor: Andreas Bechthold, Irina Treede, Steffen J. Glaser, Carsten Hofmann, Maraike Schmidt, Agnes Mühlenweg, Gerd Hauser, Gabriele Weitnauer
Publikováno v: Applied and environmental microbiology. 71(1)
Eurekanate belongs to the important class of branched-chain carbohydrates present in a wide variety of natural sources. It is a component of avilamycin A, a potent inhibitor of bacterial protein synthesis targeting the 50S ribosomal subunit. The pres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9aeabf572b5163549ae497894877867
https://pubmed.ncbi.nlm.nih.gov/15640214
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10
Activation of a silent phenazine biosynthetic gene cluster reveals a novel natural product and a new resistance mechanism against phenazines
Autor: Nadja Burkard, Hans-Peter Fiedler, Tobias Bonitz, Katrin Flinspach, Orwah Saleh, Agnes Mühlenweg, Andreas Kulik, Andreas Vente, Bertolt Gust, Stefan Polnick, Michael Lämmerhofer, Lutz Heide
Publikováno v: MedChemComm. 3:1009
The activation of silent biosynthetic gene clusters is a principal challenge for genome mining strategies in drug discovery. In the present study, a phenazine biosynthetic gene cluster was discovered in the Gram-positive bacterium Streptomyces tendae
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::002494f58982683797764c3e985c7faa
https://doi.org/10.1039/c2md20045g
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