Výsledky vyhledávání - "Agnes L Hipgrave Ederveen"

Akademický článek

Natural killer cell activation by respiratory syncytial virus‐specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc‐glycosylation

Autor: Elisabeth A vanErp, Anke J Lakerveld, Erik deGraaf, Mads D Larsen, Rutger M Schepp, Agnes L Hipgrave Ederveen, Inge ML Ahout, Cornelis AM deHaan, Manfred Wuhrer, Willem Luytjes, Gerben Ferwerda, Gestur Vidarsson, Puck B vanKasteren

Publikováno v: Clinical & Translational Immunology, Vol 9, Iss 2, Pp n/a-n/a (2020)

Abstract Objectives Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants, and there is no vaccine available. In early life, the most important contributors to protection against infectious disease

Externí odkaz: https://doaj.org/article/8ea47ac791a445a69c4c0034fd1c3987

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Akademický článek

Fish-hunting cone snail disrupts prey’s glucose homeostasis with weaponized mimetics of somatostatin and insulin

Autor: Ho Yan Yeung, Iris Bea L. Ramiro, Daniel B. Andersen, Thomas Lund Koch, Alexander Hamilton, Walden E. Bjørn-Yoshimoto, Samuel Espino, Sergey Y. Vakhrushev, Kasper B. Pedersen, Noortje de Haan, Agnes L. Hipgrave Ederveen, Baldomero M. Olivera, Jakob G. Knudsen, Hans Bräuner-Osborne, Katrine T. Schjoldager, Jens Juul Holst, Helena Safavi-Hemami

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Venomous animals have evolved diverse molecular mechanisms to incapacitate prey and defend against predators. Most venom components disrupt nervous, locomotor, and cardiovascular systems or cause tissue damage. The discovery that certain fis

Externí odkaz: https://doaj.org/article/f2fa1c3f0aa445f0bdccf7fe579b75c1

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Akademický článek

Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

Autor: Mads Delbo Larsen, Mary Lopez-Perez, Emmanuel Kakra Dickson, Paulina Ampomah, Nicaise Tuikue Ndam, Jan Nouta, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Benjamin Mordmüller, Ali Salanti, Morten Agertoug Nielsen, Achille Massougbodji, C. Ellen van der Schoot, Michael F. Ofori, Manfred Wuhrer, Lars Hviid, Gestur Vidarsson

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Here, Larsen et al. describe differences in Fc fucosylation of P. falciparum PfEMP1-specific IgG produced in response to natural infection versus VAR2CSA-type subunit vaccination, which leads to differences in the ability to induce FcγRIIIa-dependen

Externí odkaz: https://doaj.org/article/a9888fc047054d7cb375efcf290854a4

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Akademický článek

Effluent and serum protein N-glycosylation is associated with inflammation and peritoneal membrane transport characteristics in peritoneal dialysis patients

Autor: Evelina Ferrantelli, Karima Farhat, Agnes L. Hipgrave Ederveen, Karli R. Reiding, Robert H. J. Beelen, Frans J. van Ittersum, Manfred Wuhrer, Viktoria Dotz

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Abstract Mass spectrometric glycomics was used as an innovative approach to identify biomarkers in serum and dialysate samples from peritoneal dialysis (PD) patients. PD is a life-saving treatment worldwide applied in more than 100,000 patients suffe

Externí odkaz: https://doaj.org/article/c3bd45e874fd4b6eb24f1f6192150d5e

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ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab

Autor: Catarina Gomes, Henrique O Duarte, Manfred Wuhrer, Elisabete Fernandes, José Alexandre Ferreira, Lúcio Lara Santos, Paul J. Hensbergen, Stefan Mereiter, Joana Rodrigues, António Polónia, Arnoud H. de Ru, Peter A. van Veelen, Celso A. Reis, Joana Gomes, Agnes L. Hipgrave Ederveen

Publikováno v: Oncogene, 40(21), 3719-3733. SPRINGERNATURE
Oncogene

The clinical performance of the therapeutic monoclonal antibody trastuzumab in the treatment of ErbB2-positive unresectable gastric cancer (GC) is severely hampered by the emergence of molecular resistance. Trastuzumab’s target epitope is localized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b661306b2624f2d0a5dc454c1deec6df
https://doi.org/10.1038/s41388-021-01801-w

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Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

Autor: Paulina Ampomah, Lars Hviid, Mads Delbo Larsen, Morten Nielsen, Emmanuel K. Dickson, Jan Nouta, Nicaise Tuikue Ndam, Carolien A. M. Koeleman, Ali Salanti, Benjamin Mordmüller, Agnes L. Hipgrave Ederveen, Michael F. Ofori, Achille Massougbodji, Mary Lopez-Perez, Manfred Wuhrer, Gestur Vidarsson, C. Ellen van der Schoot

Publikováno v: Nature Communications, 12, 1
Nature Communications, 12
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications
Larsen, M D, Lopez-Perez, M, Dickson, E K, Ampomah, P, Tuikue Ndam, N, Nouta, J, Koeleman, C A M, Ederveen, A L H, Mordmüller, B, Salanti, A, Nielsen, M A, Massougbodji, A, van der Schoot, C E, Ofori, M F, Wuhrer, M, Hviid, L & Vidarsson, G 2021, ' Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination ', Nature Communications, vol. 12, 5838 . https://doi.org/10.1038/s41467-021-26118-w
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, 12, 1. Nature Publishing Group

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate receptor- and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody responses are a central component of naturally acquired malaria immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7382c2e64633785034e56577f9beb820
https://dspace.library.uu.nl/handle/1874/425173

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O- and N-Glycosylation of Serum Immunoglobulin A is Associated with IgA Nephropathy and Glomerular Function

Autor: H. Terence Cook, Manfred Wuhrer, Hannah J. Lomax-Browne, Florent Clerc, Alessia Visconti, Matthew C. Pickering, Viktoria Dotz, Mario Falchi, Nicholas R. Medjeral-Thomas, Agnes L. Hipgrave Ederveen

Publikováno v: J Am Soc Nephrol
Journal of the American Society of Nephrology, 32(10), 2455-2465. AMER SOC NEPHROLOGY

Background IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide and is a leading cause of renal failure. The disease mechanisms are not completely understood, but a higher abundance of galactose-deficient IgA is recognized t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107a6f3ce33f7ab657a8fa10a22a8337
https://europepmc.org/articles/PMC8722783/

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Dissecting total plasma and protein-specific glycosylation profiles in congenital disorders of glycosylation

Autor: Manfred Wuhrer, Agnes L. Hipgrave Ederveen, Melissa Baerenfaenger, Dirk Lefeber, Noortje de Haan

Publikováno v: International Journal of Molecular Sciences, 21, 20
International Journal of Molecular Sciences; Volume 21; Issue 20; Pages: 7635
International Journal of Molecular Sciences, 21
International Journal of Molecular Sciences, 21(20):7635, 1-16. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 21(20). MDPI
Bärenfänger, J M, Hipgrave Ederveen, A, de Haan, N, Lefeber, D J & Wuhrer, M 2020, ' Dissecting Total Plasma and Protein-Specific Glycosylation Profiles in Congenital Disorders of Glycosylation ', International Journal of Molecular Sciences, vol. 21, no. 20, 7635, pp. 1-16 . https://doi.org/10.3390/ijms21207635
International Journal of Molecular Sciences, Vol 21, Iss 7635, p 7635 (2020)

Protein N-glycosylation is a multifactorial process involved in many biological processes. A broad range of congenital disorders of glycosylation (CDGs) have been described that feature defects in protein N-glycan biosynthesis. Here, we present insig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c9326eaa13f572c32a9be36e467b39
https://doi.org/10.3390/ijms21207635

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Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy

Autor: Jodie L. Abrahams, Radka Saldova, Rick Kapur, Agnes L. Hipgrave Ederveen, Natalia I. Olovnikova, Kathryn L. Armour, Manfred Wuhrer, Gestur Vidarsson, Belinda Kumpel, Carolien A. M. Koeleman, Pauline M. Rudd

Publikováno v: Scientific Reports
Scientific Reports, 10(1). NATURE PUBLISHING GROUP
Scientific reports, 10(1):1464. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

Anti-D immunoglobulin (Anti-D Ig) prophylaxis prevents haemolytic disease of the fetus and newborn. Monoclonal IgG anti-Ds (mAb-Ds) would enable unlimited supplies but have differed in efficacy in FcγRIIIa-mediated ADCC assays and clinical trials. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe8c36fd7aeffb801e038aa701126fe
https://doi.org/10.1038/s41598-019-57393-9

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Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3

Publikováno v: EMBO JOURNAL
The EMBO Journal
The EMBO journal 39(15), e103457 (2020). doi:10.15252/embj.2019103457
EMBO Journal, 39(15). WILEY

Seizure protein 6 (SEZ6) is required for the development and maintenance of the nervous system, is a major substrate of the protease BACE1 and is linked to Alzheimer's disease (AD) and psychiatric disorders, but its molecular functions are not well u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c62ca4e3ff9a616aac1956d7bb9bc35
https://hdl.handle.net/21.11116/0000-0006-BA20-421.11116/0000-0006-BA1E-8

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