Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Agnes Knopf"'
Autor:
Sébastien Jeay, Stefan Diethelm, Agnes Knopf, Marie Goxe, Marie Daugan, Julie Erupathil, Julien Pothier, Davide Pozzi, Thierry Sifferlen, Lorenza Wyder, Isabelle Lyothier, Olivier Corminboeuf, Francois Lehembre, Imke Renz, Dominique Meyer
Publikováno v:
Cancer Research. 83:1809-1809
Prostaglandin E2 (PGE2) binds to four G-protein-coupled EP receptors, of which both EP2 and EP4 are abundantly expressed by tumor-infiltrating immune cells including DCs, NK cells, Tregs, cytotoxic T cells and TAMs. Signaling via EP2 and EP4 is immun
Autor:
Daniela Brodbeck, Lorenza Wyder Peters, Marie Goxe, Klaus D. Molle, Urs Regenass, Philippe Guerry, Michael N. Hall, Christoph Moroni, Marco Colombi, Agnes Knopf, Anke Thiemeyer
Publikováno v:
SLAS Discovery. 19:131-144
The mTOR pathway is a critical integrator of nutrient and growth factor signaling. Once activated, mTOR promotes cell growth and proliferation. Several components of the mTOR pathway are frequently deregulated in tumors, leading to constitutive activ