Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Agnes Gardet"'
Autor:
Agnes Gardet, Alex Pellerin, Christie-Ann McCarl, Rohan Diwanji, Wenting Wang, Douglas Donaldson, Nathalie Franchimont, Victoria P. Werth, Dania Rabah
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Objective: Plasmacytoid dendritic cells (pDCs) are a major source of Type-I Interferon (IFN-I), a key driver in cutaneous lupus erythematosus (CLE). Currently evaluated in Phase II clinical trial, 24F4A (BIIB059) is an antibody targeting BDCA2, an in
Externí odkaz:
https://doaj.org/article/d4c5a43a4a3847498b3050a9c21c46e7
Autor:
Agnes Gardet, Wei C Chou, Taylor L Reynolds, Diana B Velez, Kai Fu, Julia M Czerkowicz, Jeffrey Bajko, Ann M Ranger, Normand Allaire, Hannah M Kerns, Sarah Ryan, Holly M Legault, Robert W Dunstan, Robert Lafyatis, Matvey Lukashev, Joanne L Viney, Jeffrey L Browning, Dania Rabah
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164423 (2016)
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelera
Externí odkaz:
https://doaj.org/article/de2edfb8f586497f81cac95be2baa6e6
Autor:
Himanshu Naik, Lauren Stevenson, Alex Pellerin, Pavan Auluck, Victoria P. Werth, Dania Rabah, Taylor L. Reynolds, Richard Furie, Romy Christmann, Nathalie Franchimont, Agnes Gardet, Joseph F. Merola, C. Barbey, Stefan Hamann, Parul Gulati, Wenting Wang
Publikováno v:
Journal of Clinical Investigation. 129:1359-1371
BACKGROUND. Plasmacytoid DCs (pDC) produce large amounts of type I IFN (IFN-I), cytokines convincingly linked to systemic lupus erythematosus (SLE) pathogenesis. BIIB059 is a humanized mAb that binds blood DC antigen 2 (BDCA2), a pDC-specific recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8f58124f7b9e679ee01b310f59cf04
https://doi.org/10.1172/jci124466
https://doi.org/10.1172/jci124466
Autor:
Dania Rabah, Ti Wang, Jeffery Vessels, Kevin Guckian, Chris Roberts, Andrea Bertolotti-Ciarlet, Norm Alliare, Agnes Gardet, Holly M. Legault, Ramon G. Bonegio, Ian R. Rifkin
Publikováno v:
Poster Presentations.
Background IRAK4 is an important signaling mediator of the innate immune system. IRAK4 initiates MyD88-dependent signaling from most TLRs and from IL-1Rs, resulting in downstream production of pro-inflammatory cytokines1. Objectives Inhibition of IRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfbca7ad35dae288f2965000b98162f2
https://doi.org/10.1136/annrheumdis-2019-eular.3385
https://doi.org/10.1136/annrheumdis-2019-eular.3385
Autor:
Dania Rabah, Christie-Ann McCarl, Agnes Gardet, Rohan Diwanji, Victoria P. Werth, Douglas Donaldson, Alex Pellerin, Nathalie Franchimont, Wenting Wang
Publikováno v:
Abstracts Accepted for Publication.
Background: BIIB059 (aka 24F4A) is a monoclonal antibody that targets BDCA2, an inhibitory receptor expressed on pDCs. Plasmacytoid dendritic cells (pDCs) are a major source of Type-I Interferon (IFN-I), which is considered to be a key pathogenic dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16c8cb85f2a6b306492df2c1c4f241f8
https://doi.org/10.1136/annrheumdis-2019-eular.8319
https://doi.org/10.1136/annrheumdis-2019-eular.8319
Autor:
Serge Chwetzoff, Germain Trugnan, Agnes Gardet, Wilfried Condemine, Thibaut Eguether, Nathalie Couroussé, Catherine Etchebest
Publikováno v:
Journal of Virology
Journal of Virology, American Society for Microbiology, 2019, 93 (1), pp.1-14. ⟨10.1128/JVI.01598-18⟩
Journal of Virology, American Society for Microbiology, 2019, 93 (1), pp.1-14. ⟨10.1128/JVI.01598-18⟩
International audience; The interactions between viruses and actin cytoskeleton have been widely studied. We showed that rotaviruses remodel microfilaments in intestinal cells and demonstrated that this was due to the VP4 spike protein. Microfilament
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66d9cbe404ce9159b3c7453310acb01
https://pubmed.ncbi.nlm.nih.gov/30333172
https://pubmed.ncbi.nlm.nih.gov/30333172
Autor:
Jeroen DeGroot, Britt Sotthewes, Jeska K de Vries-Bouwstra, Kejie Li, Patrick Cullen, Joanne L. Viney, Agnes Gardet, Jamil Aarbiou, Marc Cheung, S.N. Andersen, Tom W J Huizinga, Timothy S. Zheng, Ellen Cahir-McFarland, David F. Fischer, Annemarie L. Dorjée, Loubna Chadli
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, 9
Systemic sclerosis (SSc or scleroderma) is an auto-immune disease characterized by skin fibrosis. While primary cells from patients are considered as a unique resource to better understand human disease biology, the effect of in vitro culture on thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bf5aa74571f4c6006cf556a8921991
https://pubmed.ncbi.nlm.nih.gov/30872777
https://pubmed.ncbi.nlm.nih.gov/30872777
Autor:
Bruce E. Sands, Vijay Yajnik, Sharyle Fowler, Agnes Gardet, Joshua R. Korzenik, Ramnik J. Xavier, Christine Stevens, Mark J. Daly, Ashwin N. Ananthakrishnan
Publikováno v:
Journal of Crohn's and Colitis. 8:845-851
Background and aims More than 80% of Crohn's disease (CD) patients will require surgery. Surgery is not curative and rates of re-operation are high. Identification of genetic variants associated with repeat surgery would allow risk stratification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba539ea3c9ec943010451c9cbaccf24
https://doi.org/10.1016/j.crohns.2014.01.003
https://doi.org/10.1016/j.crohns.2014.01.003
Autor:
Dania Rabah, Sarah Ryan, Robert Dunstan, Julia M. Czerkowicz, Taylor L. Reynolds, Kai Fu, Normand Allaire, Jeffrey L. Browning, Matvey E. Lukashev, Agnes Gardet, Joanne L. Viney, Wei C. Chou, Ann Ranger, Hannah M. Kerns, Jeffrey Bajko, Holly M. Legault, Diana B. Velez, Robert Lafyatis
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164423 (2016)
PLoS ONE
PLoS ONE
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4ffcf6e7f9b0c091105433f5dc7b58
http://europepmc.org/articles/PMC5070861?pdf=render
http://europepmc.org/articles/PMC5070861?pdf=render
Autor:
Isabel Ballester, Ramnik J. Xavier, Joshua R. Korzenik, John D. Rioux, Christine Stevens, Chun Li, Daniel K. Podolsky, Yair Benita, Mark J. Daly, Bruce E. Sands, Agnes Gardet
Publikováno v:
The Journal of Immunology. 185:5577-5585
LRRK2 was previously identified as a defective gene in Parkinson’s disease, and it is also located in a risk region for Crohn’s disease. In this study, we aim to determine whether LRRK2 could be involved in immune responses. We show that LRRK2 ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842be23c0dafcc6b1d5a8cc1ffa2d9c1
https://doi.org/10.4049/jimmunol.1000548
https://doi.org/10.4049/jimmunol.1000548