Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Agnes E. S. Tyburn"'
Autor:
Lapatrada Taemaitree, Aman Modi, Agnes E. S. Tyburn, Tom Brown, Afaf H. El-Sagheer, Przemyslaw Wanat, Ewa Wȩgrzyn, Diallo Traoré, Arun Shivalingam, Ysobel R Baker, Sven Epple
Publikováno v:
Journal of the American Chemical Society
Triazole linkages (TLs) are mimics of the phosphodiester bond in oligonucleotides with applications in synthetic biology and biotechnology. Here we report the RuAAC-catalyzed synthesis of a novel 1,5-disubstituted triazole (TL2) dinucleoside phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdc5410ee4f52305c2a113576cf4471
http://europepmc.org/articles/PMC8499026
http://europepmc.org/articles/PMC8499026
Autor:
Afaf H. El-Sagheer, Diallo Traoré, Agnes E. S. Tyburn, Tom Brown, Ysobel R Baker, Przemyslaw Wanat
A novel triazole linkage that mimics the phosphodiester backbone in DNA was designed, synthesised and evaluated. Unlike previous work which utilised copper to form a 1,4 triazole linkage in the DNA backbone, a ruthenium catalyst was used to yield a 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9b184be20483e8b694ad821d0ad251
https://doi.org/10.1016/j.tet.2019.130914
https://doi.org/10.1016/j.tet.2019.130914
Publikováno v:
Journal of the American Chemical Society. 139(4)
The molecular properties of the phosphodiester backbone that made it the evolutionary choice for the enzymatic replication of genetic information are not well understood. To address this, and to develop new chemical ligation strategies for assembly o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e0ee7834071aab5a0109833e9607d58
https://pubmed.ncbi.nlm.nih.gov/28097865
https://pubmed.ncbi.nlm.nih.gov/28097865