Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Agnes E Coutinho"'
Autor:
Agnes E Coutinho, Jeremy K Brown, Fu Yang, David G Brownstein, Mohini Gray, Jonathan R Seckl, John S Savill, Karen E Chapman
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54640 (2013)
Mast cells are key initiators of allergic, anaphylactic and inflammatory reactions, producing mediators that affect vascular permeability, angiogenesis and fibrosis. Glucocorticoid pharmacotherapy reduces mast cell number, maturation and activation b
Externí odkaz:
https://doaj.org/article/ec5a20e5f24d44f185911da8a047997d
Autor:
Karen E. Chapman, Christopher D. Lucas, Scott P. Webster, Adriano G. Rossi, Jonathan R. Seckl, Cristina L. Esteves, Tiina Kipari, Brian R. Walker, James S. Gilmour, Jeremy Hughes, Zhenguang Zhang, Agnes E. Coutinho, John Savill
Publikováno v:
Coutinho, A E, Kipari, T M J, Zhang, Z, Esteves, C L, Lucas, C D, Gilmour, J S, Webster, S P, Walker, B R, Hughes, J, Savill, J S, Seckl, J R, Rossi, A G & Chapman, K E 2016, ' 11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice ', Endocrinology, vol. 157, no. 7, pp. 2928-2936 . https://doi.org/10.1210/en.2016-1118
Endocrinology
Endocrinology
Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts intrinsically inert cortisone and 11-dehydrocorticosterone into active cortisol and corticoste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ca03bb6c0ab36fb10518bcbdd9f817
https://doi.org/10.1210/en.2016-1118
https://doi.org/10.1210/en.2016-1118
Autor:
Kay Samuel, Dawn E W Livingstone, Patrick W. F. Hadoke, Jonathan R. Seckl, M. Amine Bouhlel, Zhenguang Zhang, Tak Yung Man, Christopher I. White, Brian R. Walker, Giulia Chinetti-Gbaguidi, Javaid Iqbal, John Savill, Eileen Miller, Ruth Andrew, Katie M. Sullivan, Karen E. Chapman, Tijana Mitić, Bart Staels, Tiina Kipari, Christopher Schrecker, Agnes E. Coutinho
Publikováno v:
The FASEB Journal
Kipari, T, Hadoke, P W F, Iqbal, J, Man, T-Y, Miller, E, Coutinho, A E, Zhang, Z, Sullivan, K M, Mitic, T, Livingstone, D E W, Schrecker, C, Samuel, K, White, C I, Bouhlel, M A, Chinetti-Gbaguidi, G, Staels, B, Andrew, R, Walker, B R, Savill, J S, Chapman, K E & Seckl, J R 2013, ' 11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis ', The FASEB Journal, vol. 27, no. 4, pp. 1519-1531 . https://doi.org/10.1096/fj.12-219105
Kipari, T, Hadoke, P W F, Iqbal, J, Man, T-Y, Miller, E, Coutinho, A E, Zhang, Z, Sullivan, K M, Mitic, T, Livingstone, D E W, Schrecker, C, Samuel, K, White, C I, Bouhlel, M A, Chinetti-Gbaguidi, G, Staels, B, Andrew, R, Walker, B R, Savill, J S, Chapman, K E & Seckl, J R 2013, ' 11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis ', The FASEB Journal, vol. 27, no. 4, pp. 1519-1531 . https://doi.org/10.1096/fj.12-219105
11β-Hydroxysteroid dehydrogenase type-1 (11β-HSD1) converts inert cortisone into active cortisol, amplifying intracellular glucocorticoid action. 11β-HSD1 deficiency improves cardiovascular risk factors in obesity but exacerbates acute inflammatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c2b651cfa18f0c0da15d344a5c0368
http://europepmc.org/articles/PMC3606528
http://europepmc.org/articles/PMC3606528
Autor:
Mohini Gray, John Savill, Karen E. Chapman, Deborah A. Sawatzky, David G. Brownstein, Agnes E. Coutinho, Donald Salter, Spike Clay, James S. Gilmour, Jonathan R. Seckl
Publikováno v:
Endocrinology
Coutinho, A E, Gray, M, Brownstein, D G, Salter, D M, Sawatzky, D A, Clay, S, Gilmour, J S, Seckl, J R, Savill, J S & Chapman, K E 2012, ' 11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice ', Endocrinology, vol. 153, no. 1, pp. 234-240 . https://doi.org/10.1210/en.2011-1398
Coutinho, A E, Gray, M, Brownstein, D G, Salter, D M, Sawatzky, D A, Clay, S, Gilmour, J S, Seckl, J R, Savill, J S & Chapman, K E 2012, ' 11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice ', Endocrinology, vol. 153, no. 1, pp. 234-240 . https://doi.org/10.1210/en.2011-1398
Glucocorticoids profoundly influence immune responses, and synthetic glucocorticoids are widely used clinically for their potent antiinflammatory effects. Endogenous glucocorticoid action is modulated by the two isozymes of 11β-hydroxysteroid dehydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7006b8f3eae562822ed57be88aa92b88
https://doi.org/10.1210/en.2011-1398
https://doi.org/10.1210/en.2011-1398
Autor:
Karen E. Chapman, Agnes E. Coutinho
Publikováno v:
Molecular and Cellular Endocrinology
Coutinho, A E & Chapman, K E 2011, ' The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights ', Molecular and Cellular Endocrinology, vol. 335, no. 1, pp. 2-13 . https://doi.org/10.1016/j.mce.2010.04.005
Coutinho, A E & Chapman, K E 2011, ' The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights ', Molecular and Cellular Endocrinology, vol. 335, no. 1, pp. 2-13 . https://doi.org/10.1016/j.mce.2010.04.005
Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-inflammatory effects, they have been amongst the most widely used and effective treatments to control inflammatory and autoimmune diseases. However, their clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d9df604d29b7bc448d65f68d93ce73
Autor:
Jonathan R. Seckl, John Savill, Karen E. Chapman, James S. Gilmour, Mohini Gray, Agnes E. Coutinho
Publikováno v:
Annals of the New York Academy of Sciences. 1088:265-273
Glucocorticoids are widely used to treat chronic inflammatory conditions including rheumatoid arthritis. They promote mechanisms important for normal resolution of inflammation, notably macrophage phagocytosis of leukocytes undergoing apoptosis. Prer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b53e40d432fb95140d2b1709bf587e
https://doi.org/10.1196/annals.1366.030
https://doi.org/10.1196/annals.1366.030
Publikováno v:
Molecular and Cellular Endocrinology. 248:3-8
Glucocorticoids are widely used for their potent anti-inflammatory effects. Endogenous glucocorticoids are immunomodulatory and shape both adaptive and innate immune responses. Over the past decade, it has become apparent that an important level of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83bda9c0a2164036f84a364f9fde3746
https://doi.org/10.1016/j.mce.2005.11.036
https://doi.org/10.1016/j.mce.2005.11.036
Autor:
Zhenguang Zhang, Jonathan R. Seckl, Karen E. Chapman, Agnes E. Coutinho, Tiina Kipari, John Savill
Publikováno v:
Chapman, K E, Coutinho, A E, Zhang, Z, Kipari, T, Savill, J S & Seckl, J R 2013, ' Changing glucocorticoid action : 11β-hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation ', Journal of Steroid Biochemistry and Molecular Biology, vol. 137, pp. 82-92 . https://doi.org/10.1016/j.jsbmb.2013.02.002
The Journal of Steroid Biochemistry and Molecular Biology
The Journal of Steroid Biochemistry and Molecular Biology
Highlights ► 11β-HSD1 converts inert glucocorticoids into active forms, amplifying glucocorticoid action. ► 11β-HSD1 is markedly induced by pro-inflammatory cytokines. ► 11β-HSD1 deficiency/inhibition worsens acute inflammation. ► 11β-HSD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2645d520a176123c2d8879bb6bd9f7ee
https://www.pure.ed.ac.uk/ws/files/5938238/1_s2.0_S0960076013000216_main.pdf
https://www.pure.ed.ac.uk/ws/files/5938238/1_s2.0_S0960076013000216_main.pdf
Autor:
Agnes E. Coutinho, Jonathan R. Seckl, John Savill, Jeremy K. Brown, Mohini Gray, Fu Yang, Karen E. Chapman, David G. Brownstein
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 1, p e54640 (2013)
PLoS ONE, Vol 8, Iss 1, p e54640 (2013)
Mast cells are key initiators of allergic, anaphylactic and inflammatory reactions, producing mediators that affect vascular permeability, angiogenesis and fibrosis. Glucocorticoid pharmacotherapy reduces mast cell number, maturation and activation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b758f207e18892ab4d6383e1376fd1c3
https://pubmed.ncbi.nlm.nih.gov/23349944
https://pubmed.ncbi.nlm.nih.gov/23349944
Autor:
Jean-François Cailhier, Jeremy Hughes, James S. Gilmour, Zhenguang Zhang, Jonathan R. Seckl, John Savill, Agnes E. Coutinho, Tiina Kipari, Karen E. Chapman, Cristina L. Esteves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f7c03561e835db7bba0cc96ea38f35b
https://doi.org/10.1210/endo-meetings.2011.part3.p8.p2-575
https://doi.org/10.1210/endo-meetings.2011.part3.p8.p2-575