Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Agnes Denys"'
Publikováno v:
Journal of Magnesium and Alloys, Vol 12, Iss 7, Pp 2812-2825 (2024)
There is an increasing interest in biodegradable materials, such as magnesium, for orthopaedic implants. This is driven by their potential to address challenges like stress shielding and the need for secondary removal surgery. In this study, biodegra
Externí odkaz:
https://doaj.org/article/f89a28e4a8b24e5a93b9da352b2b4b0e
Autor:
Timothée Laboux, Mehdi Maanaoui, Fabrice Allain, Jean-Baptiste Gibier, Benjamin Lopez, Agnes Denys, Gaelle Grolaux, Celine Lebas, François Provôt, Steve Lancel, Marc Hazzan, Eric Boulanger, Viviane Gnemmi, Marie Frimat
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS The complement system plays a key role in the pathophysiology of renal thrombotic microangiopathies (TMA), as illustrated by atypical hemolytic uremic syndrome (HUS) characterized by a high rate of mutations in complement proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09821b8b9db0f7e1fc8e954b102f9810
https://doi.org/10.1093/ndt/gfac063.023
https://doi.org/10.1093/ndt/gfac063.023
Autor:
Irina A. Udalova, Jamie Campbell, Clive Smith, Agnes Denys, Lynn M. Williams, Dominic Kwaitkowski, Caroline Andrews, Cathleen J. Ciesielski, Brian M. J. Foxwell
IL-10 is a potent anti-inflammatory cytokine and inhibitor of TNF-α production. The molecular pathways by which IL-10 inhibits TNF-α production are obscure, with diverse mechanisms having been published. In this study, a new approach has been taken
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cee0b6d3e39fb14817bddcc32ba6475
https://ora.ox.ac.uk/objects/uuid:d594aa5a-b2e4-4d47-a019-ecce17f6394f
https://ora.ox.ac.uk/objects/uuid:d594aa5a-b2e4-4d47-a019-ecce17f6394f
Functional Consequences of a Polymorphism Affecting NF-κB p50-p50 Binding to the TNF Promoter Region
Autor:
Agnes Denys, Dominic P. Kwiatkowski, Brian M. J. Foxwell, Clive Smith, Irina A. Udalova, Hans Ackerman, Anna Richardson
Publikováno v:
Molecular and Cellular Biology. 20:9113-9119
Stimulation of the NF-kappaB pathway often causes p65-p50 and p50-p50 dimers to be simultaneously present in the cell nucleus. A natural polymorphism at nucleotide -863 in the human TNF promoter (encoding tumor necrosis factor [TNF]) region provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7739a4417d9fcd3fe17109599babaf5f
https://doi.org/10.1128/mcb.20.24.9113-9119.2000
https://doi.org/10.1128/mcb.20.24.9113-9119.2000
Autor:
Marc Feldmann, Abigail E. Hunt, Louise A. Hayes, Agnes Denys, Cathleen J. Ciesielski, Jamie Campbell, Nicole J. Horwood, Brian M. J. Foxwell, Fionula M. Brennan, Jonathan T Beech
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 173(11)
TNF-α is a key factor in a variety of inflammatory diseases. This study examines the role of p38 MAPK in the regulation of TNF-α in primary human cells relevant to inflammation, e.g., macrophages and rheumatoid synovial cells. Using a dominant nega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13934ec645d05f0e279759054999f6eb
http://ora.ox.ac.uk/objects/uuid:5a8741a2-ac79-4f99-8d52-cfb627849216
http://ora.ox.ac.uk/objects/uuid:5a8741a2-ac79-4f99-8d52-cfb627849216
Autor:
Agnès Denys, Fabrice Allain
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Alteration in the expression of heparan sulfate (HS)-modifying enzymes has been frequently observed in cancer. Consequently, dysregulation of the HS biosynthetic machinery results in dramatic changes in the HS structure, thereby impacting a range of
Externí odkaz:
https://doaj.org/article/6afd4f9832c54056b101b93f5972f122
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194676 (2018)
Heparan sulfate 3-O-sulfotransferases (HS3STs) catalyze the final maturation step of heparan sulfates. Although seven HS3ST isozymes have been described in human, 3-O-sulfation is a relatively rare modification, and only a few biological processes ha
Externí odkaz:
https://doaj.org/article/bb176db1c4a74412b1fc6b511063ee65
Publikováno v:
Molecules, Vol 23, Iss 10, p 2718 (2018)
Heparan sulfate 3-O-sulfotransferases (HS3STs) catalyze the maturation step of heparan sulfate (HS) 3-O-sulfation. This modification is relatively rare. Moreover, only a few biological processes have been described to be influenced by 3-O-sulfated HS
Externí odkaz:
https://doaj.org/article/d81f2c1d37ac48448a235767ca4b991a