Anticancer, anti-inflammatory and analgesic activities of aminoalcohol-based quinoxaline small molecules

Autor: Jannyely Moreira Neri, Paula Emília Apolônio Siqueira, Ana Luiza Cabral de Sá Leitão Oliveira, Renata Mendonça Araújo, Raimundo Fernandes de Araújo Júnior, Agnes Andrade Martins, Isabelle de Lima Marques, Rafaela Alcindo Silva, Aurigena Antunes de Araújo, Fabrício Gava Menezes

Publikováno v: Acta Cirúrgica Brasileira, Vol 39 (2024)

ABSTRACT Purpose: Bioactive molecules are relevant to fight cancer and associated conditions. Quinoxaline is a privileged N-heterocycle, notably as anticancer agents. Herein, we report the evaluation of the quinoxaline derivatives DEQX and OAQX as an

Externí odkaz: https://doaj.org/article/b88ad78b5d2145a6a2aa610aef110a78

The beneficial effects of Lacticaseibacillus casei on the small intestine and colon of Swiss mice against the deleterious effects of 5-fluorouracil

Autor: Stphannie Jamyla de Araújo Barbosa, Maisie Mitchele Barbosa Oliveira, Susana Barbosa Ribeiro, Caroline Addison Carvalho Xavier de Medeiros, Maria Laura de Souza Lima, Gerlane Coelho Bernardo Guerra, Raimundo Fernandes de Araújo Júnior, Francisco Caninde de Sousa Junior, Agnes Andrade Martins, Daniel Felipe Fernandes Paiva, Raphael Victor Silva Andrade, Conceição S. Martins Rebouças, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitâo, Aurigena Antunes de Araújo

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundIntestinal mucositis is one of the most common and important side effects of 5-fluorouracil (5-FU). Currently, there are still no specific and effective protocols for its prevention and treatment. The aim of the present study was to evaluat

Externí odkaz: https://doaj.org/article/e6aab44140ba47e4821652b320e52a46

Impact of the COVID-19 pandemic on the sleep quality of students: A meta-analysis and meta-regression

Autor: Camila de Castro Corrêa, Agnes Andrade Martins, Karinna Veríssimo Meira Taveira, Willian Santos da Silva, Joice Carrilho Fernandes, Fernanda Souza Lobo, José Stechman-Neto, Maria Renata José, Cristiano Miranda de Araujo

Publikováno v: Behavioral Sleep Medicine. :1-19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cf31ccc4df511c5d3abee6fda32f411
https://doi.org/10.1080/15402002.2023.2180005

In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model

Autor: Emily Cintia Tossi de Araújo Costa, Artur de Santana Oliveira, Aline de Sousa Barbosa Freitas Pereira, Emanuell Dos Santos Silva, Gerly Anne de Castro Brito, Caroline Addison Carvalho Xavier de Medeiros, Aurigena Antunes de Araújo, Jovelina Samara Ferreira Alves, Raimundo Fernandes de Araújo Júnior, Agnes Andrade Martins, Maria Laura de Souza Lima, Gerlane Coelho Bernardo Guerra, Arnóbio Antônio da Silva-Júnior, Renata Ferreira de Carvalho Leitão, Leandro de Santis Ferreira

Publikováno v: Pharmaceutical Biology, Vol 59, Iss 1, Pp 1576-1584 (2021)
Pharmaceutical Biology
article-version (VoR) Version of Record

Context Metformin is an important oral anti-hyperglycemic used in diabetes. Polylactic-co-glycolic acid (PLGA) has been widely used due to its reliability in controlling the release of drugs. Objective This study evaluates the in vitro-in vivo availa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584cd6364aedba491793ea3e1c57a105
https://doaj.org/article/7d4d72e176694e5aa3a792b23b8a3c96

The Receptor AT1 Appears to Be Important for the Maintenance of Bone Mass and AT2 Receptor Function in Periodontal Bone Loss Appears to Be Regulated by AT1 Receptor

Autor: Rafaela Alcindo Silva, Maria Laura de Souza Lima, Stphannie Jamyla de Araújo Barbosa, Caroline Addison Carvalho Xavier de Medeiros, Michael Bader, Raimundo Fernandes de Araújo Júnior, Gerly Anne de Castro Brito, Rômulo Camilo de Oliveira Melo, Gerlane Coelho Bernardo Guerra, Aurigena Antunes de Araújo, Renata Ferreira de Carvalho Leitão, Robson A.S. Santos, Flavia Q. Pirih, Agnes Andrade Martins

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12849, p 12849 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12849
International Journal of Molecular Sciences

A large number of experimental studies has demonstrated that angiotensin II (Ang II) is involved in key events of the inflammatory process. This study aimed to evaluate the role of Ang II type 1 (AT1) and Ang II type 2 (AT2) receptors on periodontiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b4b6988eccb3afadfa55d432c885d0
https://www.mdpi.com/1422-0067/22/23/12849