Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Agnes Acevedo"'
Autor:
Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 935 (2023)
Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using 35S-GTP
Externí odkaz:
https://doaj.org/article/14dc2c96072240f297e8663c127868ee
Autor:
Bohn, Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M.
Publikováno v:
Biomolecules; Volume 13; Issue 6; Pages: 935
Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using 35S-GTP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::59eab5949a2ddf76129f1acc76791544
Autor:
Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn
Opioid analgesics like morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Here we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using35S-GTPγS bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b6cf1fcc18e70e22d87dc30cc884931
https://doi.org/10.1101/2023.05.11.540403
https://doi.org/10.1101/2023.05.11.540403
Autor:
Edward Stahl, Cullen L. Schmid, Agnes Acevedo‐Canabal, Cai Read, Travis Grim, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbaa78bff7307785ba5137b3450afd62
https://doi.org/10.1096/fasebj.2022.36.s1.r1962
https://doi.org/10.1096/fasebj.2022.36.s1.r1962
Publikováno v:
Biological Psychiatry. 87:15-21
The mu opioid receptor (MOR) is a diversely regulated target for the alleviation of pain in the clinical setting. However, untoward side effects such as tolerance, dependence, respiratory suppression, constipation, and abuse liability detract from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e93747b979722e8d302af2658e2fba69
https://doi.org/10.1016/j.biopsych.2019.10.020
https://doi.org/10.1016/j.biopsych.2019.10.020
Autor:
Nicole M. Kennedy, Cullen L. Schmid, Agnes Acevedo-Canabal, Edward L. Stahl, Laura M. Bohn, Cai Read, Travis W. Grim, Thomas D. Bannister
Publikováno v:
Proc Natl Acad Sci U S A
The ability of a ligand to preferentially promote engagement of one signaling pathway over another downstream of GPCR activation has been referred to as signaling bias, functional selectivity, and biased agonism. The presentation of ligand bias refle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c3fb22b788a2b9c93de2a22ba74551
https://doi.org/10.1073/pnas.2102178118
https://doi.org/10.1073/pnas.2102178118
Autor:
Nicole M. Kennedy, Michael D. Cameron, Cullen L. Schmid, Laura M. Bohn, Edward L. Stahl, Jo-Hao Ho, Fani Pantouli, Travis W. Grim, Thomas D. Bannister, Agnes Acevedo-Canabal
Publikováno v:
Neuropsychopharmacology
It has been demonstrated that opioid agonists that preferentially act at μ-opioid receptors to activate G protein signaling over βarrestin2 recruitment produce antinociception with less respiratory suppression. However, most of the adverse effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ba507bd11f0a076c1bf54d1049ade0
https://doi.org/10.1038/s41386-019-0491-8
https://doi.org/10.1038/s41386-019-0491-8
Autor:
Martine Behra, Lorena González-Sepúlveda, Gaurav K. Varshney, Roberto Rodriguez-Morales, Guillermo A. Yudowski, Luis Colón-Cruz, Agnes Acevedo-Canabal, Shawn M. Burgess
Publikováno v:
Cannabis and Cannabinoid Research
Background and Objectives: The cannabinoid receptor 2 (CB2) was previously implicated in brain functions, including complex behaviors. Here, we assessed the role of CB2 in selected swimming behaviors in zebrafish larvae and developed an in vivo upsca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490acc41610282ea1d164e7d07a5d64d
https://doi.org/10.1089/can.2018.0025
https://doi.org/10.1089/can.2018.0025
Autor:
Laura M. Bohn, Thomas D. Bannister, Nicole M. Kennedy, Fani Pantouli, Cullen L. Schmid, Travis W. Grim, Agnes Acevedo-Canabal
The mu opioid receptor-selective agonist, SR-17018, preferentially activates GTPγS binding over βarrestin2 recruitment in cellular assays. In mice, SR-17018 stimulates GTPγS binding in brainstem and produces antinociception with potencies similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef4f1118c0d2f478d50ae8582676843
https://doi.org/10.1101/2020.10.16.341776
https://doi.org/10.1101/2020.10.16.341776