Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Agnes Acevedo"'
Autor:
Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 935 (2023)
Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using 35S-GTP
Externí odkaz:
https://doaj.org/article/14dc2c96072240f297e8663c127868ee
Autor:
Bohn, Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M.
Publikováno v:
Biomolecules; Volume 13; Issue 6; Pages: 935
Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using 35S-GTP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::59eab5949a2ddf76129f1acc76791544
Autor:
Agnes Acevedo-Canabal, Travis W. Grim, Cullen L. Schmid, Nina McFague, Edward L. Stahl, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn
Opioid analgesics like morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Here we show that morphine, fentanyl, SR-17018, and oliceridine have submaximal intrinsic efficacy in the mouse striatum using35S-GTPγS bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b6cf1fcc18e70e22d87dc30cc884931
https://doi.org/10.1101/2023.05.11.540403
https://doi.org/10.1101/2023.05.11.540403
Publikováno v:
Biological Psychiatry. 87:15-21
The mu opioid receptor (MOR) is a diversely regulated target for the alleviation of pain in the clinical setting. However, untoward side effects such as tolerance, dependence, respiratory suppression, constipation, and abuse liability detract from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e93747b979722e8d302af2658e2fba69
https://doi.org/10.1016/j.biopsych.2019.10.020
https://doi.org/10.1016/j.biopsych.2019.10.020
Autor:
Nicole M. Kennedy, Michael D. Cameron, Cullen L. Schmid, Laura M. Bohn, Edward L. Stahl, Jo-Hao Ho, Fani Pantouli, Travis W. Grim, Thomas D. Bannister, Agnes Acevedo-Canabal
Publikováno v:
Neuropsychopharmacology
It has been demonstrated that opioid agonists that preferentially act at μ-opioid receptors to activate G protein signaling over βarrestin2 recruitment produce antinociception with less respiratory suppression. However, most of the adverse effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ba507bd11f0a076c1bf54d1049ade0
https://doi.org/10.1038/s41386-019-0491-8
https://doi.org/10.1038/s41386-019-0491-8
Autor:
Martine Behra, Lorena González-Sepúlveda, Gaurav K. Varshney, Roberto Rodriguez-Morales, Guillermo A. Yudowski, Luis Colón-Cruz, Agnes Acevedo-Canabal, Shawn M. Burgess
Publikováno v:
Cannabis and Cannabinoid Research
Background and Objectives: The cannabinoid receptor 2 (CB2) was previously implicated in brain functions, including complex behaviors. Here, we assessed the role of CB2 in selected swimming behaviors in zebrafish larvae and developed an in vivo upsca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490acc41610282ea1d164e7d07a5d64d
https://doi.org/10.1089/can.2018.0025
https://doi.org/10.1089/can.2018.0025
Autor:
Laura M. Bohn, Thomas D. Bannister, Nicole M. Kennedy, Fani Pantouli, Cullen L. Schmid, Travis W. Grim, Agnes Acevedo-Canabal
The mu opioid receptor-selective agonist, SR-17018, preferentially activates GTPγS binding over βarrestin2 recruitment in cellular assays. In mice, SR-17018 stimulates GTPγS binding in brainstem and produces antinociception with potencies similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef4f1118c0d2f478d50ae8582676843
https://doi.org/10.1101/2020.10.16.341776
https://doi.org/10.1101/2020.10.16.341776
Autor:
Nicole M. Kennedy, Laura M. Bohn, Michael D. Cameron, Thomas D. Bannister, Cullen L. Schmid, Agnes Acevedo-Canabal, Fani Pantouli, Travis W. Grim
Publikováno v:
Neuropharmacology
The mu opioid receptor-selective agonist, SR-17018, preferentially activates GTPγS binding over βarrestin2 recruitment in cellular assays, thereby demonstrating signaling bias. In mice, SR-17018 stimulates GTPγS binding in brainstem and produces a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d39c11ce3ba1e113454f82a9b6929e
https://pubmed.ncbi.nlm.nih.gov/33345829
https://pubmed.ncbi.nlm.nih.gov/33345829
Autor:
Martine Behra, Luis Colón-Cruz, Agnes Acevedo, Maria A. Sosa, Aranza I. Torrado, Jonathan Crooke-Rosado, Lauren A. Kristofco, Bryan W. Brooks
Publikováno v:
Ecotoxicology and Environmental Safety. 147:670-680
Detection and toxicity assessment of waterborne contaminants are crucial for protecting human health and the environment. Development of easy-to-implement, rapid and cost-effective tools to measure anthropogenic effects on watersheds are critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c9e77ce84583f4e0fc6b7a21760822
https://doi.org/10.1016/j.ecoenv.2017.09.018
https://doi.org/10.1016/j.ecoenv.2017.09.018