Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Agnes, Holczbauer"'
Autor:
Claire Chung, Bert M. Verheijen, Zoe Navapanich, Eric G. McGann, Sarah Shemtov, Guan-Ju Lai, Payal Arora, Atif Towheed, Suraiya Haroon, Agnes Holczbauer, Sharon Chang, Zarko Manojlovic, Stephen Simpson, Kelley W. Thomas, Craig Kaplan, Peter van Hasselt, Marc Timmers, Dorothy Erie, Lin Chen, Jean-Franćois Gout, Marc Vermulst
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The molecular mechanisms that ensure faithful transcription of genetic information are still unclear. Chung et al. identify various genes, alleles and processes that affect the fidelity of transcription multiple organisms, suggesting evolutionary con
Externí odkaz:
https://doaj.org/article/096147bca5dd41de8f7b050e54beb959
Autor:
Celia Sequera, Margherita Grattarola, Agnes Holczbauer, Rosanna Dono, Stefania Pizzimenti, Giuseppina Barrera, Kirk J. Wangensteen, Flavio Maina
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-15 (2022)
Abstract Enhanced activation of the transcription factor MYC and of the receptor tyrosine kinase MET are among the events frequently occurring in hepatocellular carcinoma (HCC). Both genes individually act as drivers of liver cancer initiation and pr
Externí odkaz:
https://doaj.org/article/a829f5c6113e456886087b0a98957784
Autor:
Claire Chung, Eric McGann, Lambertus Verheijen, Zoe Navapanich, Sarah Shemtov, Guan-Ju Lai, Atif Towheed, Suraiya Haroon, Agnes Holczbauer, Sharon Chang, Zarko Manojlovic, Stephen Simpson, W. Kelley Thomas, Craig Kaplan, Peter van Hasselt, H.Th.Marc Timmers, Dorothy A. Erie, Lin Chen, Jean-Francois Gout, Marc Vermulst
Accurate transcription is required for the faithful expression of genetic information. Surprisingly though, little is known about the molecular mechanisms that control the fidelity of transcription, or the conservation of these mechanisms across the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaab6b869dfec0c5afaf83c32031ceda
https://doi.org/10.21203/rs.3.rs-1175415/v1
https://doi.org/10.21203/rs.3.rs-1175415/v1
Autor:
Valentina M. Factor, Jens U. Marquardt, Agnes Holczbauer, Snorri S. Thorgeirsson, Chiara Raggi, Marian E. Durkin, Jesper B. Andersen, Matthew C. Gillen, Daekwan Seo
Publikováno v:
Hepatology. 59:2251-2262
Reversal of DNA hypermethylation and associated gene silencing is an emerging cancer therapy approach. Here we addressed the impact of epigenetic alterations and cellular context on functional and transcriptional reprogramming of hepatocellular carci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df560145c1fc97b7bc5becbb5010559b
https://doi.org/10.1002/hep.27026
https://doi.org/10.1002/hep.27026
Autor:
Valentina M. Factor, Agnes Holczbauer, Yun-Han Lee, Snorri S. Thorgeirsson, Mitsuteru Kitade, Jesper B. Andersen, Akira Tomokuni, Kosuke Kaji, Elizabeth A. Conner, Seung-Bum Lee, Hirofumi Akita, Jens U. Marquardt, Daekwan Seo
Publikováno v:
Genes & Development. 27:1706-1717
The relative contribution of hepatocyte growth factor (HGF)/MET and epidermal growth factor (EGF)/EGF receptor (EGFR), two key signal transduction systems in the normal and diseased liver, to fate decisions of adult hepatic progenitor cells (HPCs) ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9b942e59a68707bb8bbc6907228967
https://doi.org/10.1101/gad.214601.113
https://doi.org/10.1101/gad.214601.113
Autor:
Daekwan Seo, Hirofumi Akita, Valentina M. Factor, Marian E. Durkin, David E. Kleiner, Jesper B. Andersen, Chiara Raggi, Snorri S. Thorgeirsson, Mitsuteru Kitade, Agnes Holczbauer, Jens U. Marquardt
Publikováno v:
Gastroenterology. 145:221-231
Background & Aims Human primary liver cancer is classified into biologically distinct subgroups based on cellular origin. Liver cancer stem cells (CSCs) have been recently described. We investigated the ability of distinct lineages of hepatic cells t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a117fdba13fcff950bc145da56d19500
https://doi.org/10.1053/j.gastro.2013.03.013
https://doi.org/10.1053/j.gastro.2013.03.013
Autor:
Seung Bum Lee, Valentina M. Factor, Kye-Yoon Park, Dongho Choi, Agnes Holczbauer, Snorri S. Thorgeirsson, Daekwan Seo, Elizabeth A. Conner, Jens U. Marquardt
Publikováno v:
STEM CELLS. 30:997-1007
Recent studies suggested that induced pluripotent stem cells (iPSCs) retain a residual donor cell gene expression, which may impact their capacity to differentiate into cell of origin. Here, we addressed a contribution of a lineage stage-specific don
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75247a4fb7dbc3fea32bb263a86c7a3
https://doi.org/10.1002/stem.1074
https://doi.org/10.1002/stem.1074
Autor:
Jens U. Marquardt, Chiara Raggi, Matthew C. Gillen, Elizabeth A. Conner, Valentina M. Factor, Snorri S. Thorgeirsson, David A. Geller, Jesper B. Andersen, Yun-Han Lee, Agnes Holczbauer, Mitsuteru Kitade, Itzhak Avital, Daekwan Seo
Publikováno v:
Hepatology. 54:1031-1042
Epigenetic mechanisms play critical roles in stem cell biology by maintaining pluripotency of stem cells and promoting differentiation of more mature derivatives. If similar mechanisms are relevant for the cancer stem cell (CSC) model, then epigeneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca7edb1278d71d61971101aeefe84e9
https://doi.org/10.1002/hep.24454
https://doi.org/10.1002/hep.24454
Autor:
Ashley S. Denney, Jacob Gauer, Jennifer Schleit, Matt Kaeberlein, James W. Jorgenson, Katie J. Wolfe, J. Will Thompson, Mara C. Duncan, Jeffrey N. Strathern, Victoria J. Madden, Suraiya Haroon, Daniel W. Summers, Chao-Wei Hung, Michael J. Lang, M. Arthur Moseley, George L. Sutphin, Agnes Holczbauer, Douglas M. Cyr, Stephanie Moore, Marc Vermulst, Dorothy A. Erie, Joanne M. Caine
Publikováno v:
Nature Communications. 6
Nature Communications 6, Article number: 8065 (2015); Published 25 August 2015; Updated 14 October 2015 The original version of this Article contained an error in the spelling of the authors J. Will Thompson and M. Arthur Moseley, which were incorrec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f88421f8010b2696e64d83bca5686414
https://doi.org/10.1038/ncomms9738
https://doi.org/10.1038/ncomms9738
Autor:
Marc, Vermulst, Ashley S, Denney, Michael J, Lang, Chao-Wei, Hung, Stephanie, Moore, M Arthur, Moseley, Arthur M, Mosely, J Will, Thompson, William J, Thompson, Victoria, Madden, Jacob, Gauer, Katie J, Wolfe, Daniel W, Summers, Jennifer, Schleit, George L, Sutphin, Suraiya, Haroon, Agnes, Holczbauer, Joanne, Caine, James, Jorgenson, Douglas, Cyr, Matt, Kaeberlein, Jeffrey N, Strathern, Mara C, Duncan, Dorothy A, Erie
Publikováno v:
Nature Communications. 6
Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to display error-prone transcription. We discover that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a302268f8807fdbbe586d3d3d6376761
https://doi.org/10.1038/ncomms9065
https://doi.org/10.1038/ncomms9065