Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Agnel P, Joseph"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, the authors present Protein Interface-score (PI-score), a machine learning-based metric that has been trained on protein–protein interfaces’ features from high-resolution crystal structures. They use the PI-score to evaluate the protein–p
Externí odkaz:
https://doaj.org/article/acd3b58ac1e54f71ae0b83863127e269
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/6a2e874b63714b44a5e055fe0245d2d5
Autor:
Mateusz Olek, Agnel Praveen Joseph
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Significant technological developments and increasing scientific interest in cryogenic electron microscopy (cryo-EM) has resulted in a rapid increase in the amount of data generated by these experiments and the derived atomic models. Robust measures
Externí odkaz:
https://doaj.org/article/efed9543829b40e7a8dac2a824f5c736
Autor:
Anaïs Menny, Marina Serna, Courtney M. Boyd, Scott Gardner, Agnel Praveen Joseph, B. Paul Morgan, Maya Topf, Nicholas J. Brooks, Doryen Bubeck
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to e
Externí odkaz:
https://doaj.org/article/4bd0eaed6b53416380fc69476cf0e63b
Autor:
Jonathan Barnoud, Hubert Santuz, Pierrick Craveur, Agnel Praveen Joseph, Vincent Jallu, Alexandre G. de Brevern, Pierre Poulain
Publikováno v:
PeerJ, Vol 5, p e4013 (2017)
This paper describes the development and application of a suite of tools, called PBxplore, to analyze the dynamics and deformability of protein structures using Protein Blocks (PBs). Proteins are highly dynamic macromolecules, and a classical way to
Externí odkaz:
https://doaj.org/article/d5495b4dbe5f4417a7e06af766ba7316
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38805 (2012)
The constant increase in the number of solved protein structures is of great help in understanding the basic principles behind protein folding and evolution. 3-D structural knowledge is valuable in designing and developing methods for comparison, mod
Externí odkaz:
https://doaj.org/article/df8ca4cf21524ce7ba807ad8c9771f3f
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18401 (2011)
BACKGROUND: Secondary structures are elements of great importance in structural biology, biochemistry and bioinformatics. They are broadly composed of two repetitive structures namely α-helices and β-sheets, apart from turns, and the rest is associ
Externí odkaz:
https://doaj.org/article/7ea4c158000046fb99e97f1fbd8570e5
Autor:
Lara Al-Olabi, Satyamaanasa Polubothu, Katherine Dowsett, Katrina A. Andrews, Paulina Stadnik, Agnel P. Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Mary Glover, Kristiana Gordon, Darren Hargrave, Susan M. Huson, Thomas S. Jacques, Gregory James, Hannah Kondolf, Loshan Kangesu, Kim M. Keppler-Noreuil, Amjad Khan, Marjorie J. Lindhurst, Mark Lipson, Sahar Mansour
Publikováno v:
Journal of Clinical Investigation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::76cb63bc3cdab0023cb3c892e80e47b5
Autor:
Katherine Dowsett, Mark H. Lipson, M. Glover, Jean-Baptiste Rivière, Rachel G. Knox, Loshan Kangesu, Veronica A. Kinsler, Zhiqiang Zeng, Aditi Murthy, Juling Ong, Neil W. Bulstrode, Amjad Khan, Alan Pittman, Susan M Huson, Darren Hargrave, W. Baird, Alex Virasami, Gregory James, Rahul Shah, Caroline Mahon, Anda Mosica, Celia Moss, Katrina A. Andrews, Robert Semple, Justine O'Hara, Kristiana Gordon, E Elizabeth Patton, Sahar Mansour, Maja Topf, Anna Thomas, Thomas S. Jacques, Kim M. Keppler-Noreuil, Hannah Kondolf, Julie C. Sapp, Marjorie J Lindhurst, Victoria E. R. Parker, Agnel P Joseph, Alex M. Barnacle, Satyamaanasa Polubothu, Paulina Stadnik, Regula Waelchli, Neil J. Sebire, Graeme Clark, L. Al-Olabi, Bran Sivakumar, Leslie G Biesecker
Publikováno v:
Parallel session abstracts.
Background Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels that lead to stroke, life-threatening bleeds, disfigurement, overgrowth, and/or pain. Therapeutic options are severely limited and multi-disciplinary m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa5816567599607d196b6e722c80ea65
https://doi.org/10.1136/archdischild-2017-084620.30
https://doi.org/10.1136/archdischild-2017-084620.30
Autor:
Pierrick, Craveur, Agnel P, Joseph, Jeremy, Esque, Tarun J, Narwani, Floriane, Noël, Nicolas, Shinada, Matthieu, Goguet, Sylvain, Leonard, Pierre, Poulain, Olivier, Bertrand, Guilhem, Faure, Joseph, Rebehmed, Amine, Ghozlane, Lakshmipuram S, Swapna, Ramachandra M, Bhaskara, Jonathan, Barnoud, Stéphane, Téletchéa, Vincent, Jallu, Jiri, Cerny, Bohdan, Schneider, Catherine, Etchebest, Narayanaswamy, Srinivasan, Jean-Christophe, Gelly, Alexandre G, de Brevern
Publikováno v:
Frontiers in Molecular Biosciences
Protein structures are valuable tools to understand protein function. Nonetheless, proteins are often considered as rigid macromolecules while their structures exhibit specific flexibility, which is essential to complete their functions. Analyses of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::02b6f852d69f67dfb6da027a8e11e870