Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Agnel, Sfeir"'
Autor:
Grace Oh, Annie Wang, Lidong Wang, Jiufeng Li, Gregor Werba, Daniel Weissinger, Ende Zhao, Surajit Dhara, Rosmel E. Hernandez, Amanda Ackermann, Sarina Porcella, Despoina Kalfakakou, Igor Dolgalev, Emily Kawaler, Talia Golan, Theodore H. Welling, Agnel Sfeir, Diane M. Simeone
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors mutations in homologous recombination–repair (HR-repair) proteins in 20%–25% of cases. Defects in HR impart a specific vulnerability to poly ADP ribose polymerase
Externí odkaz:
https://doaj.org/article/9914b8b0574846e7832524ad7f4fa02e
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100112- (2020)
Summary: Advances in imaging technologies, gene editing, and fluorescent molecule development have made real-time imaging of nucleic acids practical. Here, we detail methods for imaging the human telomerase RNA template, hTR via the use of three inse
Externí odkaz:
https://doaj.org/article/441cfb2f2d774f5dba4891b7ae570b0e
Autor:
Pascal Chartrand, Agnel Sfeir
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Telomerase plays a key role in the immortalization of cancer cells by maintaining telomeres length. Using single-molecule imaging of telomerase RNA molecules in cancer cells, we recently reported novel insights into the role of Cajal bodies in telome
Externí odkaz:
https://doaj.org/article/cc2811d2a9944ab4a2317078697ea8ed
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100104- (2020)
Summary: Fluorescent in situ hybridization (FISH) on the RNA moiety of human telomerase (hTR) with 50-mer probes detects hTR RNA accumulated in Cajal bodies. Using both live-cell imaging and single-molecule inexpensive FISH, our published work reveal
Externí odkaz:
https://doaj.org/article/aadc26f97b02435498ada899af27e14d
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Publikováno v:
Trends Cell Biol
Telomeres are distinctive structures that protect the ends of linear chromosomes and ensure genome stability. They are composed of long tracks of repetitive and G-rich DNA that is bound by shelterin, a dedicated six-subunit protein complex. In somati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844b8e808d89bfa5ea87f5ce82bd1d00
https://doi.org/10.1016/j.tcb.2021.12.007
https://doi.org/10.1016/j.tcb.2021.12.007
Autor:
Alexandra M. Pinzaru, Robert A. Hom, Angela Beal, Aaron F. Phillips, Eric Ni, Timothy Cardozo, Nidhi Nair, Jaehyuk Choi, Deborah S. Wuttke, Agnel Sfeir, Eros Lazzerini Denchi
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2170-2184 (2016)
Genome sequencing studies have revealed a number of cancer-associated mutations in the telomere-binding factor POT1. Here, we show that when combined with p53 deficiency, depletion of murine POT1a in common lymphoid progenitor cells fosters genetic i
Externí odkaz:
https://doaj.org/article/41a03a414ad34762bf0a0a0270c0b8f8
Autor:
Raymond Mario Barry, Olivia Sacco, Amel Mameri, Martin Stojaspal, William Kartsonis, Pooja Shah, Pablo De Ioannes, Ctirad Hofr, Jacques Côté, Agnel Sfeir
Publikováno v:
Genes & Development. 36:313-330
In mammals, the conserved telomere binding protein Rap1 serves a diverse set of nontelomeric functions, including activation of the NF-kB signaling pathway, maintenance of metabolic function in vivo, and transcriptional regulation. Here, we uncover t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884702b5350f541191267471a43462a1
https://doi.org/10.1101/gad.349039.121
https://doi.org/10.1101/gad.349039.121
Autor:
Adrian S. Tong, J. Lewis Stern, Agnel Sfeir, Melissa Kartawinata, Titia de Lange, Xu-Dong Zhu, Tracy M. Bryan
Publikováno v:
Cell Reports, Vol 13, Iss 8, Pp 1633-1646 (2015)
The yeast homologs of the ATM and ATR DNA damage response kinases play key roles in telomerase-mediated telomere maintenance, but the role of ATM/ATR in the mammalian telomerase pathway has been less clear. Here, we demonstrate the requirement for AT
Externí odkaz:
https://doaj.org/article/4fd8e00a804548c68ef0c02e8b27f389
Double-strand breaks in mitochondrial DNA (mtDSBs) lead to the degradation of the circular genomes and a reduction in copy number. However, it is unclear how mtDSBs are sensed and what signaling pathways are activated in response to mtDNA damage. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ec8b55006801a7c28da4534e5986c44
https://doi.org/10.1101/2022.10.01.510431
https://doi.org/10.1101/2022.10.01.510431
