Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Agnès Poirier"'
Autor:
Uwe Grether, Richard H. Foxton, Sabine Gruener, Claudia Korn, Atsushi Kimbara, Anja Osterwald, Elisabeth Zirwes, Sabine Uhles, Janina Thoele, Nadine Colé, Mark Rogers-Evans, Stephan Röver, Matthias Nettekoven, Rainer E. Martin, Jean-Michel Adam, Jürgen Fingerle, Caterina Bissantz, Wolfgang Guba, André Alker, Anna M. Szczesniak, Ross F. Porter, Tom J. Toguri, Franco Revelant, Agnès Poirier, Camille Perret, Lotte Winther, Antonello Caruso, Filomena Fezza, Mauro Maccarrone, Melanie E. M. Kelly, Sascha Fauser, Christoph Ullmer
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionPreclinical studies suggest that cannabinoid receptor type 2 (CB2R) activation has a therapeutic effect in animal models on chronic inflammation and vascular permeability, which are key pathological features of diabetic retinopathy (DR).
Externí odkaz:
https://doaj.org/article/91d1c3e1c6e44284b2f5d719fd280ff1
Autor:
Agnès Poirier, Heidemarie Kletzl, Cordula Stillhart, Stephen Fowler, Kenichi Umehara, Andreas Guenther, Andreas Brink, Nicole A. Kratochwil, Dietrich Tuerck, Christophe Husser, Mark Savage, Mohammed Ullah, Lutz Mueller, Yumi Cleary, Katja Heinig
Publikováno v:
Drug Metabolism and Disposition. 50:65-75
Small molecules that present complex absorption, distribution, metabolism, and elimination (ADME) properties can be challenging to investigate as potential therapeutics. Acquiring data through standard methods can yield results that are insufficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a42eb9cb10d47b49d0cb86fb0a1206ac
https://doi.org/10.1124/dmd.121.000563
https://doi.org/10.1124/dmd.121.000563
Autor:
Stephen, Fowler, Andreas, Brink, Yumi, Cleary, Andreas, Günther, Katja, Heinig, Christophe, Husser, Heidemarie, Kletzl, Nicole, Kratochwil, Lutz, Mueller, Mark, Savage, Cordula, Stillhart, Dietrich, Tuerck, Mohammed, Ullah, Kenichi, Umehara, Agnès, Poirier
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(1)
Small molecules that present complex absorption, distribution, metabolism, and elimination (ADME) properties can be challenging to investigate as potential therapeutics. Acquiring data through standard methods can yield results that are insufficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4530dce338c940f32f354504129eb183
https://pubmed.ncbi.nlm.nih.gov/34620695
https://pubmed.ncbi.nlm.nih.gov/34620695
Autor:
Agnès Poirier
WINNER OF THE 2022 FRENCH HERITAGE SOCIETY BOOK AWARD The profound emotion felt around the world upon seeing images of Notre-Dame in flames opens up a series of questions: Why was everyone so deeply moved? Why does Notre-Dame so clearly crystallise w
Autor:
Agnès Poirier
Vor dem Hintergrund weltgeschichtlicher Verwerfungen erlebt Paris in den Jahren 1940 bis 1950 seine Wiedergeburt: Mit großer Erzählkunst lässt Agnès Poirier den Flair und das geistig-künstlerische Leben in einer der aufregendsten Metropolen der
Autor:
Tianle Yang, Hasane Ratni, Emmanuel Pinard, Nanjing Zhang, Hongyan Qi, Nikolai Naryshkin, Priya Vazirani, Stephan Kirchner, Xiaoyan Zhang, Karen S. Chen, Amal Dakka, Lutz Mueller, Friedrich Metzger, Woll Matthew G, Sergey Paushkin, Xin Zhao, Marla Weetall, Gary Mitchell Karp, Kathleen D. McCarthy, Agnès Poirier, Wolfgang Muster, Pascale David-Pierson, Luke Green, Irene Gerlach, Anthony Turpoff, Dietrich Tuerck
Publikováno v:
Journal of Medicinal Chemistry. 59:6086-6100
Spinal muscular atrophy (SMA) is the leading genetic cause of infant and toddler mortality, and there is currently no approved therapy available. SMA is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. These mutations or del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893761e5e7ae4b3161242bfe14378561
https://doi.org/10.1021/acs.jmedchem.6b00459
https://doi.org/10.1021/acs.jmedchem.6b00459
Autor:
Agnès Poirier, Lutz Mueller, Heidemarie Kletzl, Chien-Ping Ko, Stefan Kustermann, Omar Khwaja, Hasane Ratni, Zhihua Feng, Johan Bylund, Bjoern Jacobsen, Michael Reutlinger, Melanie Guérard, Emmanuel Pinard, Sergey Paushkin, John D. Baird, Nikolai Naryshkin, Stefanie Bendels, Anne Marquet, Nora Denk, Xin Zhao, Philippe Jablonski, Martin Ebeling, Luke Green, Friedrich Metzger, Andreas Zeller, Barbara Mueller, Karen S. Chen, Marla Weetall
Publikováno v:
Journal of medicinal chemistry. 61(15)
SMA is an inherited disease that leads to loss of motor function and ambulation and a reduced life expectancy. We have been working to develop orally administrated, systemically distributed small molecules to increase levels of functional SMN protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9e69d504357bfed8927794453d1858
https://pubmed.ncbi.nlm.nih.gov/30044619
https://pubmed.ncbi.nlm.nih.gov/30044619
Autor:
Yumi Cleary, Katja Heinig, Lutz Müller, Hasane Ratni, Omar Khwaja, Nicolas Frances, Paul Jordan, Agnès Poirier, Birgit Jaber, Tobias Bergauer, Heidemarie Kletzl, Nada Al Kotbi, Stefan Sturm, Anne Marquet, Andreas Günther, Christian Czech, Nikhat Parkar
Publikováno v:
British journal of clinical pharmacology. 85(1)
Aims Risdiplam (RG7916, RO7034067) is an orally administered, centrally and peripherally distributed, survival of motor neuron 2 (SMN2) mRNA splicing modifier for the treatment of spinal muscular atrophy (SMA). The objectives of this entry-into-human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a179691a66077906bc034e6725650d
https://pubmed.ncbi.nlm.nih.gov/30302786
https://pubmed.ncbi.nlm.nih.gov/30302786
Autor:
Agnès Poirier
An incandescent group portrait of the midcentury artists and thinkers whose lives, loves, collaborations, and passions were forged against the wartime destruction and postwar rebirth of ParisIn this fascinating tour of a celebrated city during one of