Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Agnès Hautefeuille"'
Autor:
Sandra Ortiz-Cuaran, Stephanie Villar, Ahmad Besaratinia, Doriane Gouas, Agnès Hautefeuille, Gerd P. Pfeifer, Isabelle Chemin, Pierre Hainaut, Myriam Lereau, Olivier Hantz, Ghislaine Martel-Planche, Andre Nogueira da Costa, Pascale Berthillon
Publikováno v:
Journal of General Virology. 93:640-650
Infection by hepatitis B virus (HBV) and dietary exposure to aflatoxin B1 (AFB1) are the main risk factors for the development of chronic liver disease and hepatocellular carcinoma (HCC). How these factors cooperate is still largely unknown. AFB1 act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64388a4ee31fe1867311b33eb2a5ddab
https://doi.org/10.1099/vir.0.032482-0
https://doi.org/10.1099/vir.0.032482-0
Autor:
Virginie Marcel, V Vijayakumar, Pierre Hainaut, H Hafsi, Charlotte Sagne, Agnès Hautefeuille, Magali Olivier, Lynnette Fernandez-Cuesta
Publikováno v:
Oncogene. 29:2691-2700
The tumor suppressor p53 protein is activated by genotoxic stress and regulates genes involved in senescence, apoptosis and cell-cycle arrest. Nine p53 isoforms have been described that may modulate suppressive functions of the canonical p53 protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ddcb604f12cadf9dd5a9e6d88a6fa3
https://doi.org/10.1038/onc.2010.26
https://doi.org/10.1038/onc.2010.26
Autor:
Agnès Hautefeuille, Klas G. Wiman, Vladimir J.N. Bykov, Jeremy Lambert, Hong Shi, Claude Caron de Fromentel, Pierre Hainaut
Publikováno v:
Carcinogenesis. 29:1428-1434
Hepatocellular carcinoma (HCC) is highly lethal due to limited curative options. In high-incidence regions, such as parts of Africa and Southeastern Asia, >50% of cases carry an AGG to AGT mutation at codon 249 of the TP53 gene, considered as a 'sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df64bb850270837453c01935e1f8db96
https://doi.org/10.1093/carcin/bgm266
https://doi.org/10.1093/carcin/bgm266
Autor:
Catherine Cavard, Alain Puisieux, C Caron de Fromentel, C. Ruptier, Pierre Hainaut, V. Tribollet, A. Petitjean, Fabien Chardon, Agnès Hautefeuille
Publikováno v:
Carcinogenesis. 29:273-281
TP63, a member of the TP53 gene family, encodes two groups of three isoforms (alpha, beta and gamma). The TAp63 isoforms act as transcription factors. The DeltaNp63 isoforms lack the main transcription activation domain and act as dominant-negative i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b094f55ecdfd44bd3167deee46f71c5
https://doi.org/10.1093/carcin/bgm258
https://doi.org/10.1093/carcin/bgm258
Autor:
Umberto Gelatti, Agnès Hautefeuille, Rayjean J. Hung, Paul Brennan, Donatella Placidi, Stefano Porru, Christian Malaveille, Paolo Boffetta, Angela Carta
Publikováno v:
Carcinogenesis. 25:973-978
Tobacco smoking and occupational exposure are major risk factors of bladder cancer via exposure to polycyclic aromatic hydrocarbons (PAHs) and aromatic amines, which lead to oxidative stress and DNA damage. Several enzymes, which play key roles in ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3945f151eef910d03e5cbdb0abbc2f0
https://doi.org/10.1093/carcin/bgh080
https://doi.org/10.1093/carcin/bgh080
Publikováno v:
European Journal of Cancer Prevention. 13:83-86
Cytochrome P450 1B1 (CYP1B1) is implicated in the activation of potentially carcinogenic xenobiotics and oestrogens. The polymorphism of the CYP1B1 gene at codon 432 (Val-->Leu) is associated with change in catalytic function. In a case-series study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8bebb17a50dbc04e0f0ebe8b2a94b9
https://doi.org/10.1097/00008469-200402000-00013
https://doi.org/10.1097/00008469-200402000-00013
Publikováno v:
International Journal of Cancer. 107:652-657
Genetic polymorphisms of enzymes involved in the metabolism of xenobiotics and estrogens might play a role in breast carcinogenesis related to environmental exposures. In a case-only study on 282 women with breast cancer, we studied the interaction e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed75417868e08de4127f291136c56144
https://doi.org/10.1002/ijc.11432
https://doi.org/10.1002/ijc.11432
Autor:
Barbara Alemar, Patricia Ashton-Prolla, Guido Lenz, Alessandro Bersch Osvaldt, Rafael Roesler, Gilberto Schwartsmann, Agnès Hautefeuille, Juliana Giacomazzi, Ana Lucia Abujamra, Patricia Izetti, Caroline Brunetto de Farias, Pierre Hainaut
Publikováno v:
Investigational new drugs. 32(5)
TP53 mutation is a common event in many cancers, including pancreatic adenocarcinoma, where it occurs in 50-70 % of cases. In an effort to reactivate mutant p53 protein, several new drugs are being developed, including PRIMA-1 and PRIMA-1(Met)/APR-24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4deb2c16475a02be16c277ba6f3cbf09
https://pubmed.ncbi.nlm.nih.gov/24838627
https://pubmed.ncbi.nlm.nih.gov/24838627
Autor:
Paolo Vineis, Armelle Munnia, Marco Peluso, Laura Fiorini, Agnès Hautefeuille, Christian Malaveille, Cinzia Magagnotti, Luisa Airoldi
Publikováno v:
Scopus-Elsevier
The 'Mediterranean diet', a diet rich in cereals, fruit and vegetables, has been associated with lowering the risk of a variety of cancers of the digestive tract and the bladder. In a previous study, we showed that the high phenolic content these die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7dbc849301edbf658ccaf7ba861e56c
https://doi.org/10.1093/carcin/21.2.183
https://doi.org/10.1093/carcin/21.2.183
Autor:
Peter Boyle, A.B. Lowenfels, Christian Malaveille, Patrick Maisonneuve, Helmut Bartsch, Agnès Hautefeuille
Publikováno v:
European Journal of Cancer Prevention. 7:215-223
Carcinogens present in cigarette smoke and diet have been associated with pancreatic cancer. We hypothesized that heterocyclic and aromatic amines implicated in these exposures could be involved as causative agents and that therefore genetic variatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b3d3eae3182fd559f730e0d59fa4fa4
https://doi.org/10.1097/00008469-199806000-00006
https://doi.org/10.1097/00008469-199806000-00006