Epileptic seizure clustering and accumulation at transition from activity to rest in GAERS rats

Autor: Hieu Tran, Reda El Mahzoum, Agnès Bonnot, Ivan Cohen

Publikováno v: Frontiers in Neurology, Vol 14 (2024)

Knowing when seizures occur may help patients and can also provide insight into epileptogenesis mechanisms. We recorded seizures over periods of several days in the Genetic Absence Epileptic Rat from Strasbourg (GAERS) model of absence epilepsy, whil

Externí odkaz: https://doaj.org/article/27d5ba6ad02941cebdbbad0368d2a45e

Single‐fluorophore biosensors based on conformation‐sensitive GFP variants

Autor: Agnès Bonnot, Ludovic Tricoire, Bertrand Lambolez, Elvire Guiot, Laetitia Cavellini, Régine Hepp

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2014, 28 (3), pp.1375-1385. ⟨10.1096/fj.13-240507⟩
FASEB Journal, 2014, 28 (3), pp.1375-1385. ⟨10.1096/fj.13-240507⟩

International audience; The -strands of GFP form a rigid barrel that protects the chromophore from external influence. Herein, we identified specific mutations in -strand 7 that render the chromophore sensitive to interactions of GFP with another pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e9dd966f21330917c5e3724b672104
https://doi.org/10.1096/fj.13-240507

Noncholinergic excitatory actions of motoneurons in the neonatal mammalian spinal cord

Autor: George Z. Mentis, Dannette Shanon Richards, Agnès Bonnot, Francisco J. Alvarez, David González-Forero, Michael J. O'Donovan, Ricardo Zerda

Publikováno v: Proceedings of the National Academy of Sciences. 102:7344-7349

Mammalian spinal motoneurons are considered to be output elements of the spinal cord that generate exclusively cholinergic actions on Renshaw cells, their intraspinal synaptic targets. Here, we show that antidromic stimulation of motor axons evokes d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82452520f1436567b897ed6581869014
https://doi.org/10.1073/pnas.0502788102

Effect of posture on the onset of fictive locomotion in the decerebrate rabbit preparation

Autor: Agnès Bonnot, Anne-Marie Bouc, Guy Viala, Denise Viola

Publikováno v: Neuroscience Letters. 208:9-12

Spontaneous locomotor episodes were recorded from hindlimb muscle nerves of decerebrate curarized rabbit preparations. Changes in the static position of both hindfeet (from extended to flexed) or of the head (from horizontal to bent forward) were sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268863a49ddd4d26bebb2f1d4d382b6a
https://doi.org/10.1016/0304-3940(96)12533-7

Electroporation loading of calcium-sensitive dyes into the CNS

Autor: Agnès Bonnot, Jesse Skoch, George Z. Mentis, Michael J. O'Donovan

Publikováno v: Journal of neurophysiology. 93(3)

Calcium imaging of neural network function has been limited by the extent of tissue labeled or the time taken for labeling. We now describe the use of electroporation—an established technique for transfecting cells with genes—to load neurons with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66833b3191ec53202f75c8631ca568ef
https://pubmed.ncbi.nlm.nih.gov/15509647