Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Agnès Amador"'
Autor:
Erica Vit, Jerome F. Hayes, Francois-Rene Alexandre, Cyril B. Dousson, Christophe Claude Parsy, David D. Pascoe, Catherine Caillet, Marie-Pierre Lioure, Neil Hodnett, Elodie Rosinovsky, John Edward Richardson, Guillaume Bret, Stéphanie Bot, Agnès Amador, Gary T. Borrett, Bernadette Choudary, Arlène Roland, Daniel Da Costa, Alan Ironmonger, John D. Hayler, Augustine Ochen, Séverine Bonaric, David Colclough, Richard K. Bellingham
Publikováno v:
Organic Process Research & Development. 22:200-206
A new and improved synthetic route to an intermediate in the synthesis of the phosphinate ester GSK2248761A is described. In the key step, we describe the first process-scale example of a palladium-catalyzed phosphorus–carbon coupling to give the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17aba0e5462710cfa14470fea5b10eb
https://doi.org/10.1021/acs.oprd.7b00356
https://doi.org/10.1021/acs.oprd.7b00356
Autor:
David Dukhan, Thierry Convard, Rachid Rahali, Agnès Amador, Anna Giulia Loi, Valeria Mascia, Massimiliano LaColla, Julien Milhau, Eric Badaroux, Maria Seifer, Loredana Onidi, Ludovic Griffe, Claire Pierra Rouviere, Joe McCarville, Dominique Louis Nestor Ghislain Surleraux, Efisio Sais, Daniel Da Costa, David Standring, Jean-François Griffon, Frédéric Leroy, Michel Liuzzi, Jean-Laurent Paparin, Cyril B. Dousson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4536-4541
The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells and, as a consequence, is an attractive target for selective inhibition. This Letter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0889ad7344d0de4eb0df64906929abdc
https://doi.org/10.1016/j.bmcl.2016.01.042
https://doi.org/10.1016/j.bmcl.2016.01.042
Autor:
Elodie Rosinovsky, Catherine Caillet, Chiara Musiu, Jingyang Wang, Marie-Pierre Lioure, Arlène Roland, Luana Vargiu, Jocelyn Jakubik, Alistair Stewart, Michel Liuzzi, Richard Storer, Stéphanie Bot, Daniel Da Costa, Sébastien Maldonado, Barbara Poddesu, David Standring, Christophe Claude Parsy, Cyril B. Dousson, Christophe Trochet, Séverine Bonaric, Francois-Rene Alexandre, Maria Seifer, Adel Moussa, Benjamin Alexander Mayes, Agnès Amador, Luke Hubbard, Thierry Convard
Publikováno v:
Journal of Medicinal Chemistry. 59:1891-1898
Here, we describe the design, synthesis, biological evaluation, and identification of a clinical candidate non-nucleoside reverse transcriptase inhibitors (NNRTIs) with a novel aryl-phospho-indole (APhI) scaffold. NNRTIs are recommended components of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176c9163cb45c8243cc2fc43da5fe84d
https://doi.org/10.1021/acs.jmedchem.5b01430
https://doi.org/10.1021/acs.jmedchem.5b01430
Autor:
Jean-Laurent Paparin, Thierry Convard, Catherine Caillet, Stéphanie Bot, Dominique Louis Nestor Ghislain Surleraux, Claire Pierra, Valeria Mascia, Maria Seifer, Jean-François Griffon, Efisio Sais, Agnès Amador, David Dukhan, Cyril B. Dousson, Elodie Rosinosky, Loredana Onidi, Anna Giulia Loi, Rachid Rahali, Eric Badaroux, Massimiliano LaColla, Frédéric Leroy, David Standring, Michel Liuzzi, Joe McCarville, Julien Milhau, Ludovic Griffe, Daniel Da Costa
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(11)
Hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells, and as a consequence is an attractive target for selective inhibition. This paper descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cabbb65889368ef3bd04a5068480e29
https://pubmed.ncbi.nlm.nih.gov/28416131
https://pubmed.ncbi.nlm.nih.gov/28416131
Publikováno v:
Collection of Czechoslovak Chemical Communications. 71:991-1010
As part of our anti-hepatitis C program, we recently discovered 2'-C-methylcytidine (1) and 2'-C-methyluridine (2), which are potent inhibitors in cell culture of several viruses (bovine viral diarrhea virus (BVDV), yellow fever virus (YFV)) closely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3343a522bba0efff938b0d0a4b02f4
https://doi.org/10.1135/cccc20060991
https://doi.org/10.1135/cccc20060991
Autor:
Agnès Amador, A. Moussa, Richard Storer, Gilles Gosselin, Séverine Mathieu, Claire Pierra, Samira Benzaria
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids
Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2005, 24, pp.767-770
Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2005, 24, pp.767-770
In order to improve the oral bioavailability of 2′-C-methylcytidine, a potent anti-HCV agent, the corresponding 3′-O-L-valinyl ester derivative (NM 283) has been synthesized. Based on its ease of synthesis and its physicochemical properties, NM 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ded53366d77e0c447f42e3fb69f5f4
https://doi.org/10.1081/ncn-200060112
https://doi.org/10.1081/ncn-200060112
Autor:
Richard Storer, Thierry Convard, Catherine Caillet, Agnès Amador, Cyril B. Dousson, Jocelyn Jakubik, Michel Liuzzi, Luana Vargiu, Francois-Rene Alexandre, Maria Seifer, Arlène Roland, Chiara Musiu, Barbara Poddesu, David Standring, Stéphanie Bot
Publikováno v:
Journal of medicinal chemistry. 54(1)
A novel series of 3-aryl-phospho-indole (API) non-nucleoside reverse transcriptase inhibitors of HIV-1 was developed. Chemical variation in the phosphorus linker led to the discovery of 3-phenyl-methyl-phosphinate-2-carboxamide 14, which possessed ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e4e6b1084e4cdaa69a2111389ee857
https://pubmed.ncbi.nlm.nih.gov/21142105
https://pubmed.ncbi.nlm.nih.gov/21142105
Autor:
Samira Benzaria, Jean-Pierre Sommadossi, Erika Cretton-Scott, Agnès Amador, Claire Pierra, Steven Mathieu, John Mao, Gilles Gosselin, Marc D'Amours, D.N. Standring, Richard Storer, A. Moussa, Edward G Bridges
Publikováno v:
Journal of medicinal chemistry. 49(22)
In our search for new therapeutic agents against chronic hepatitis C, a ribonucleoside analogue, 2'-C-methylcytidine, was discovered to be a potent and selective inhibitor in cell culture of a number of RNA viruses, including the pestivirus bovine vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8de42d3fb4a534a48c110a4bc6289c
https://pubmed.ncbi.nlm.nih.gov/17064080
https://pubmed.ncbi.nlm.nih.gov/17064080