Zobrazeno 1 - 10
of 381
pro vyhledávání: '"Agnès, Noël"'
Autor:
Odeta Meçe, Diede Houbaert, Maria-Livia Sassano, Tania Durré, Hannelore Maes, Marco Schaaf, Sanket More, Maarten Ganne, Melissa García-Caballero, Mila Borri, Jelle Verhoeven, Madhur Agrawal, Kathryn Jacobs, Gabriele Bergers, Silvia Blacher, Bart Ghesquière, Mieke Dewerchin, Johan V. Swinnen, Stefan Vinckier, María S. Soengas, Peter Carmeliet, Agnès Noël, Patrizia Agostinis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Autophagy is essential to endothelial cell homeostasis. Here the authors show that lipophagy in LEC supports fatty acid oxidation to sustain a mitochondrial-Prox1 gene expression circuit and promote response of LEC to lymphangiogenic mediators.
Externí odkaz:
https://doaj.org/article/6f053768112c4a3e957fc921d9943221
Publikováno v:
Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-6 (2022)
Abstract Background Ovarian tissue cryopreservation and transplantation (OTCTP) is currently the main option available to preserve fertility in prepubertal patients undergoing aggressive cancer therapy treatments. However, a major limitation of OTCTP
Externí odkaz:
https://doaj.org/article/c3077de153ef483cb733d3b6a3e56e21
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionSolid tumors consist of tumor cells associated with stromal and immune cells, secreted factors and extracellular matrix (ECM), which together constitute the tumor microenvironment. Among stromal cells, activated fibroblasts, known as canc
Externí odkaz:
https://doaj.org/article/dfc78a7f2c0a422d9dd8663009d2f264
Autor:
Laura Dupont, Loïc Joannes, Florent Morfoisse, Silvia Blacher, Christine Monseur, Christophe F. Deroanne, Agnès Noël, Alain C.M.A. Colige
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
The capacity of ADAMTS3 to cleave pro-VEGFC into active VEGFC able to bind its receptors and to stimulate lymphangiogenesis has been clearly established during embryonic life. However, this function of ADAMTS3 is unlikely to persist in adulthood beca
Externí odkaz:
https://doaj.org/article/83ea507b27234f5f9bd851cd33cc643a
Autor:
Déborah Neyrinck-Leglantier, Julien Lesage, Silvia Blacher, Arnaud Bonnomet, Walter Hunziker, Agnès Noël, Valérian Dormoy, Béatrice Nawrocki-Raby, Christine Gilles, Myriam Polette
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro, we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of sev
Externí odkaz:
https://doaj.org/article/9d1943e2c9f4411984740c92b60c8388
Autor:
François Lallemand, Natacha Leroi, Silvia Blacher, Mohamed Ali Bahri, Evelyne Balteau, Philippe Coucke, Agnès Noël, Alain Plenevaux, Philippe Martinive
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
PurposeNeoadjuvant radiotherapy (NeoRT) improves tumor local control and facilitates tumor resection in many cancers. Some clinical studies demonstrated that both timing of surgery and RT schedule influence tumor dissemination, and subsequently patie
Externí odkaz:
https://doaj.org/article/302b6fbef78544918dbcb14881ec14bd
Autor:
Charlotte Bertrand, Pierre Van Meerbeeck, Grégoire de Streel, Noora Vaherto-Bleeckx, Fatima Benhaddi, Loïc Rouaud, Agnès Noël, Pierre G. Coulie, Nicolas van Baren, Sophie Lucas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
When combined with anti-PD-1, monoclonal antibodies (mAbs) against GARP:TGF-β1 complexes induced more frequent immune-mediated rejections of CT26 and MC38 murine tumors than anti-PD-1 alone. In both types of tumors, the activity of anti-GARP:TGF-β1
Externí odkaz:
https://doaj.org/article/f45f3173cc314e1ab9566494a2b0c62a
Autor:
Bernard Pirotte, Deniz Arslan, Matthieu Schoumacher, Sébastien Dilly, Benaïssa Elmoualij, Danièle Zorzi, Pascale Quatresooz, Vincent Lambert, Agnès Noël, Pascal de Tullio
Publikováno v:
Medicinal Chemistry. 19:276-296
Aims: The present work describes the synthesis and the biological evaluation of novel compounds acting as pyruvate dehydrogenase kinase (PDK) inhibitors. These drugs should become a new therapeutic approach for the treatment of pathologies improved b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d453fce0aedee612d74ebebd89fa317b
https://doi.org/10.2174/1573406418666220819102627
https://doi.org/10.2174/1573406418666220819102627
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Cancers are complex ecosystems composed of malignant cells embedded in an intricate microenvironment made of different non-transformed cell types and extracellular matrix (ECM) components. The tumor microenvironment is governed by constantly evolving
Externí odkaz:
https://doaj.org/article/7be57ff7d4ec467381bee1debb1e2200
Autor:
Melissa García-Caballero, Jenny Paupert, Silvia Blacher, Maureen Van de Velde, Ana Rodríguez Quesada, Miguel Angel Medina, Agnès Noël
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-17 (2017)
Abstract Background Lymphatic metastasis is one of the leading causes of death in patients with different types of cancer and is the main prognostic factor for the disease survival. The formation of new lymphatic vessels (lymphangiogenesis) in primar
Externí odkaz:
https://doaj.org/article/e2590a057e674631982446aef7236f18