Targeted agents in patients with progressive glioblastoma-A systematic meta-analysis of randomized clinical trials.

Autor: Ippen FM; Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany., Scherm A; Wilhelm Sander-NeuroOncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg, Germany., Kessler T; Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Hau P; Wilhelm Sander-NeuroOncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg, Germany., Agkatsev S; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany., Baurecht H; Institute of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany., Wick W; Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Knüttel H; University Library, University of Regensburg, Regensburg, Germany., Leitzmann MF; Institute of Epidemiology and Preventive Medicine, University Hospital Regensburg, Regensburg, Germany., Seliger-Behme C; Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.; Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany.

Publikováno v: Cancer medicine [Cancer Med] 2024 Jun; Vol. 13 (12), pp. e7362.

Are we providing best-available care to newly diagnosed glioblastoma patients? Systematic review of phase III trials in newly diagnosed glioblastoma 2005-2022.

Autor: Oster C; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Schmidt T; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Agkatsev S; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Lazaridis L; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Kleinschnitz C; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Sure U; German Cancer Consortium (DKTK), DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Scheffler B; German Cancer Consortium (DKTK), DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Kebir S; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Glas M; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Publikováno v: Neuro-oncology advances [Neurooncol Adv] 2023 Sep 04; Vol. 5 (1), pp. vdad105. Date of Electronic Publication: 2023 Sep 04 (Print Publication: 2023).

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First multicentric real-life experience with the combination of CCNU and temozolomide in newly diagnosed MGMT promoter methylated IDH wildtype glioblastoma.

Autor: Lazaridis L; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Medicine Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK)., Bumes E; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany., Cäcilia Spille D; Department of Neurosurgery, University Hospital Münster, Münster, Germany., Schulz T; Department of Neurosurgery, University Hospital of Würzburg, Würzburg, Germany., Heider S; Department of Radiotherapy and Radiation Oncology, University Hospital Leipzig, Leipzig, Germany., Agkatsev S; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Medicine Essen, Essen, Germany., Schmidt T; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Medicine Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK)., Blau T; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK).; Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Oster C; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Medicine Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK)., Feldheim J; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Medicine Essen, Essen, Germany., Stummer W; Department of Neurosurgery, University Hospital Münster, Münster, Germany., Kessler AF; Department of Neurosurgery, University Hospital of Würzburg, Würzburg, Germany., Seidel C; Department of Radiotherapy and Radiation Oncology, University Hospital Leipzig, Leipzig, Germany., Grauer O; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Hau P; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany., Sure U; German Cancer Consortium (DKTK), Partner Site University Medicine Essen, Essen, Germany.; Department of Neurosurgery and Spine Surgery, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen, Germany., Keyvani K; Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Herrlinger U; Division of Clinical Neurooncology, Department of Neurology and Center for Integrated Oncology, University Hospital Bonn, Bonn, Germany., Kleinschnitz C; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Stuschke M; Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Herrmann K; German Cancer Consortium (DKTK), Partner Site University Medicine Essen, Essen, Germany.; Department of Nuclear Medicine, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Deuschl C; German Cancer Consortium (DKTK), Partner Site University Medicine Essen, Essen, Germany.; Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Breuer S; Institute of Neuroradiology, University Hospital Frankfurt, Frankfurt, Germany., Hattingen E; Institute of Neuroradiology, University Hospital Frankfurt, Frankfurt, Germany., Scheffler B; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK).; German Cancer Research Center (DKFZ), Heidelberg, Germany., Kebir S; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Medicine Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK)., Glas M; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Medicine Essen, Essen, Germany.; DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), DKTK Partner Site, University Medicine Essen, University Duisburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK).

Publikováno v: Neuro-oncology advances [Neurooncol Adv] 2022 Aug 24; Vol. 4 (1), pp. vdac137. Date of Electronic Publication: 2022 Aug 24 (Print Publication: 2022).

RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo.

Autor: Hibbitt, O¹, Agkatsev, S¹, Owen, C¹, Cioroch, M¹, Seymour, L², Channon, K³, Wade-Martins, R¹

Publikováno v: Gene Therapy. Apr2012, Vol. 19 Issue 4, p463-467. 5p. 3 Graphs.