Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Agisilaos Kourmatzis"'
Challenges in the Development and Application of Organ-on-Chips for Intranasal Drug Delivery Studies
Autor:
Muhammad Usman Khan, Xinyu Cai, Zhiwei Shen, Taye Mekonnen, Agisilaos Kourmatzis, Shaokoon Cheng, Hanieh Gholizadeh
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1557 (2023)
With the growing demand for the development of intranasal (IN) products, such as nasal vaccines, which has been especially highlighted during the COVID-19 pandemic, the lack of novel technologies to accurately test the safety and effectiveness of IN
Externí odkaz:
https://doaj.org/article/7cd3e08dab7f4889834b00b49518636b
Autor:
Hanieh Gholizadeh, Shaokoon Cheng, Agisilaos Kourmatzis, Hanwen Xing, Daniela Traini, Paul M. Young, Hui Xin Ong
Publikováno v:
Bioengineering, Vol 9, Iss 4, p 150 (2022)
Developing novel drug formulations and progressing them to the clinical environment relies on preclinical in vitro studies and animal tests to evaluate efficacy and toxicity. However, these current techniques have failed to accurately predict the cli
Externí odkaz:
https://doaj.org/article/9613b930395f494998a859a1fca9eaab
Autor:
Xinyu Cai, Bingjie Ma, Agisilaos Kourmatzis, Fatemeh Salehi, Ann Lee, Dino Farina, Kim Chan, Shaokoon Cheng
Publikováno v:
Aerosol Science and Technology. 56:802-818
Publikováno v:
Energy & Fuels. 36:4224-4233
Publikováno v:
Atomization and Sprays.
Publikováno v:
Energy & Fuels. 35:16115-16127
Publikováno v:
Powder Technology. 389:163-177
This study uses computational fluid dynamics to model powder fluidisation in a turbulent channel flow. A two-fluid model is adopted for simulations. Closures are provided through the kinetic theory of granular flow where particle energy fluctuations
Autor:
Agisilaos Kourmatzis, Warren H. Finlay
Publikováno v:
Advanced drug delivery reviews. 191
Publikováno v:
International Journal of Pharmaceutics. 637:122871
Autor:
Hanieh Gholizadeh, Shaokoon Cheng, Agisilaos Kourmatzis, Daniela Traini, Paul Young, Zara Sheikh, Hui Xin Ong
Publikováno v:
Biosensors and Bioelectronics. 223:115010
The current organ-on-chip platforms used for studying respiratory drug delivery are limited to the administration of drug solutions and suspensions, lacking the in vivo aerosol drug administration and aerosol interaction with the respiratory tract ba