Výsledky vyhledávání - "Agis Kydonieus"

Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies

Autor: Ajay K. Banga, Agis Kydonieus, Yun Bai, Vishal Sachdeva

Publikováno v: International Journal of Pharmaceutics. 441:9-18

Levonorgestrel (LNG) is the most commonly used progestin in contraception. In this study we report the use of an alternative progestin desogestrel for transdermal contraception. The drug was found to be significantly more permeable as compared to LNG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff30b427e9d50c8e44d4e090d26c76a1
https://doi.org/10.1016/j.ijpharm.2012.12.014

Zobrazit plný text záznamu

Use of a Sulfated Chitosan Derivative to Reduce Bladder Inflammation in the Rat

Autor: John W. Downie, Juan Zhou, Julie L. Jordan, Timothy D.G. Lee, Susan Elizabeth Henderson, Clive M. Elson, Agis Kydonieus

Publikováno v: Urology. 70:1014-1018

Interstitial cystitis is a chronic, debilitating disease of the bladder. Treatments using intravesicular inoculation of long-chain polysaccharide formulations, such as hyaluronic acid or anti-inflammatory agents, have been used to some effect. The ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc86b2c1b891a49abb7548b27b4ab4e
https://doi.org/10.1016/j.urology.2007.07.056

Zobrazit plný text záznamu

N-sulfonato-N,O-carboxymethylchitosan: A novel polymeric absorption enhancer for the oral delivery of macromolecules

Autor: Clive Halifax Elson, Susan Elizabeth Henderson, Agis Kydonieus, Maya Thanou

Publikováno v: Journal of Controlled Release. 117:171-178

Chitosan has been shown to act on the mucosal epithelial barriers mainly when protonated at acidic pH values in which it is soluble. Soluble chitosan is able to improve the permeation and absorption of neutral to cationic macromolecules only, as it f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5344b1b76fd3f0fc2a1533b9427696e
https://doi.org/10.1016/j.jconrel.2006.11.002

Zobrazit plný text záznamu

cis-Urocanic Acid Induces Mast Cell Degranulation and Release of Preformed TNF--α: A Possible Mechanism Linking UVB and cis-Urocanic Acid to Immunosuppression of Contact Hypersensitivity

Autor: Agis Kydonieus, George F. Murphy, John J. Wille

Publikováno v: Skin Pharmacology and Physiology. 12:18-27

The search for effective inhibitors of transdermal drug-induced contact sensitization was directed to dermal mast-cell-degranulating agents (MCDA). Human skin organ cultures were employed to test whether cis-urocanic acid (C-UA) and other potential M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0082fc0cda7666df398b19129f5153fc
https://doi.org/10.1159/000029842

Zobrazit plný text záznamu

Several Different Ion Channel Modulators Abrogate Contact Hypersensitivity in Mice

Autor: Richard S. Kalish, Agis Kydonieus, John J. Wille

Publikováno v: Skin Pharmacology and Physiology. 12:12-17

A major obstacle in transdermal delivery of drugs is the development of adverse skin sensitization reactions. We tested the concept that ion channel modulators as a class of agents suppress contact hypersensitivity in a mouse model. Mice were sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ebbaf23f8e343cc71b9105dd5c8870
https://doi.org/10.1159/000029841

Zobrazit plný text záznamu

Inhibition of Irritation and Contact Hypersensitivity by Ethacrynic Acid

Autor: Richard S. Kalish, Agis Kydonieus, John J. Wille

Publikováno v: Skin Pharmacology and Physiology. 11:279-288

The immunosuppressive effect of topical ethacrynic acid (ECA) was tested on both the induction and elicitation phases of contact sensitization in a mouse model. ECA (0.5% in vehicle) reduced the sensitization response by >50% when the sensitizer was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab51a48c107272338caeea5febd486a0
https://doi.org/10.1159/000029838

Zobrazit plný text záznamu

Prevention of contact hypersensitivity to topically applied drugs by ethacrynic acid: potential application to transdermal drug delivery

Autor: John J. Wille, Agis Kydonieus, Richard S. Kalish, Jonathan A. Wood

Publikováno v: Journal of Controlled Release. 48:79-87

Transdermal drug delivery systems have many advantages. However, the extension of this technology to additional drugs is limited by the development of contact sensitization to topically applied drugs. Ion channel modulators have been reported to inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b58ca4b8ef21a19bf7db59d3342a1cb
https://doi.org/10.1016/s0168-3659(97)00035-7

Zobrazit plný text záznamu

Inhibition of irritation and contact hypersensitivity by phenoxyacetic acid methyl ester in mice

Autor: Richard S. Kalish, Agis Kydonieus, John J. Wille

Publikováno v: Skin pharmacology and applied skin physiology. 13(2)

New anti-irritant treatments are required to prevent irritation and sensitization reactions to consumer medicines and dermatological drugs. We report here that phenoxyacetic acid methyl ester (PAME) is an effective agent to prevent and treat irritant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad73be2f5db1303b078bb2e6ac2ed7bc
https://pubmed.ncbi.nlm.nih.gov/10754454

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání