Editorial: Molecular mechanisms underlying exercise-alleviated sarcopenic obesity

Autor: Brisamar Estébanez, Chun-Jung Huang, María J. Cuevas

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

Externí odkaz: https://doaj.org/article/b8a1a8fbb2b44232bd8edee08913f03e

The antibiotic doxycycline impairs cardiac mitochondrial and contractile function

Autor: Diederik W. D. Kuster, Michel van Weeghel, Vida Alizadeh Tazehkandi, Luciënne Baks-Te Bulte, Gustav J. Strijkers, Bram F. Coolen, Ntsiki M. Held, Bianca J. J. M. Brundel, Riekelt H. Houtkooper, Mariah R R Daal, Marit Wiersma, Rob C. I. Wüst

Publikováno v: Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100 . https://doi.org/10.3390/ijms22084100
International journal of molecular sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 22(8):4100, 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 8
Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100, pp. 1-19 . https://doi.org/10.3390/ijms22084100
International Journal of Molecular Sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 22, Iss 4100, p 4100 (2021)

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba143ec8e34cf744f53dea11e2bd5101
https://doi.org/10.3390/ijms22084100

A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity

Autor: Iva Miljkovic, Anne B. Newman, Paola Sebastiani, Bharat Thyagarajan, Joseph H. Lee, Joseph M. Zmuda, Robert M. Boudreau, Megan M Marron, Kaare Christensen, Long Life Family Study, Mary K. Wojczynski, Mary F. Feitosa

Publikováno v: Metabolism
Marron, M M, Miljkovic, I, Boudreau, R M, Christensen, K, Feitosa, M F, Lee, J H, Sebastiani, P, Thyagarajan, B, Wojczynski, M K, Zmuda, J M, Newman, A B & Long Life Family Study 2019, ' A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity ', Metabolism: Clinical and Experimental, vol. 94, pp. 28-38 . https://doi.org/10.1016/j.metabol.2019.01.010

Background: Long-lived individuals and their offspring have healthier metabolic characteristics than expected, such as more favorable levels of fasting glucose, insulin, and lipids than controls without longevity. Dysregulation in metabolic pathways

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816960f26dd60eb3dfec654d360c44d5
https://doi.org/10.1016/j.metabol.2019.01.010

Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson���s Disease

Autor: Stefanie Seiler, Lukas Andereggen, Hans Rudolf Widmer, Ekkehard Hewer, Gian-Carlo Eyer, Stefano Di Santo

Publikováno v: Eyer, Gian-Carlo; Di Santo, Stefano; Hewer, Ekkehard; Andereggen, Lukas; Seiler, Stefanie; Widmer, Hans Rudolf (2021). Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson’s Disease. Cells, 10(12) MDPI 10.3390/cells10123368
Cells, Vol 10, Iss 3368, p 3368 (2021)
Cells
Cells; Volume 10; Issue 12; Pages: 3368
Cells, vol. 10, no. 12, pp. 3368

Parkinson’s disease is mainly characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Together with the small number, the high vulnerability of the dopaminergic neurons is a major pathogenic culprit of Par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1658244281552db14bd32eb1a1c5138

The Dysfunctional MDM2–p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy

Autor: Zhuohao Liu, Jin Kui Yang, Kenneth K.Y. Cheng, Philip Hallenborg, Baile Wang, Leigang Jin, Kelvin K.L. Wu, Aimin Xu

Publikováno v: Liu, Z, Jin, L, Yang, J-K, Wang, B, Wu, K K, Hallenborg, P, Xu, A & Cheng, K K 2018, ' The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Ageing Related Metabolic Complications by Induction of Lipodystrophy ', Diabetes, vol. 67, no. 11, pp. 2397-2409 . https://doi.org/10.2337/db18-0684

Profound loss and senescence of adipose tissues are hallmarks of advanced age, but the underlying cause and their metabolic consequences remain obscure. Proper function of the murine double minute 2 (MDM2)–p53 axis is known to prevent tumorigenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03e325711897542011e839f66c205f1
https://doi.org/10.2337/db18-0684