Hemolysis in the spleen drives erythrocyte turnover

Autor: W F J van IJcken, Thomas R. L. Klei, Sietse Q. Nagelkerke, Martijn Veldthuis, Benjamin Nota, R van Zwieten, J Dalimot, Frederik P. J. Mul, F P J van Alphen, T Rademakers, Edwin Oole, Alexander B. Meijer, Mark Hoogenboezem, Taco W. Kuijpers, Søren K. Moestrup, Pia Svendsen, R. van Bruggen

Publikováno v: Klei, T R L, Dalimot, J, Nota, B, Veldthuis, M, Mul, F P J, Rademakers, T, Hoogenboezem, M, Nagelkerke, S Q, van IJcken, W F J, Oole, E, Svendsen, P, Moestrup, S K, van Alphen, F P J, Meijer, A B, Kuijpers, T W, van Zwieten, R & van Bruggen, R 2020, ' Hemolysis in the spleen drives erythrocyte turnover ', Blood, vol. 136, no. 14, pp. 1579-1589 . https://doi.org/10.1182/blood.2020005351
Blood, 136(14), 1579-1589. The American Society of Hematology
Blood, 136(14), 1579. Amer Soc Hematology
Blood, 136(14), 1579-1589. American Society of Hematology

Red pulp macrophages (RPMs) of the spleen mediate turnover of billions of senescent erythrocytes per day. However, the molecular mechanisms involved in sequestration of senescent erythrocytes, their recognition, and their subsequent degradation by RP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35ab5a9fde47f37d72acf4e0a11838b
https://pure.au.dk/portal/da/publications/hemolysis-in-the-spleen-drives-erythrocyte-turnover(507ae87c-abcf-472f-8db3-ed1373f52970).html

Glycine promotes longevity in caenorhabditis elegans in a methionine cycle-dependent fashion

Autor: Arwen W. Gao, Aldo Jongejan, Rashmi Kamble, Georges E. Janssens, Michel van Weeghel, Marte Molenaars, Alyson W. MacInnes, Riekelt H. Houtkooper, Yasmine J. Liu, Rebecca L. McIntyre

Publikováno v: PLoS Genetics, 15(3):e1007633. Public Library of Science
PLoS Genetics, Vol 15, Iss 3, p e1007633 (2019)
PLOS Genetics
PLoS Genetics
PLoS genetics, 15(3):e1007633. Public Library of Science

The deregulation of metabolism is a hallmark of aging. As such, changes in the expression of metabolic genes and the profiles of amino acid levels are features associated with aging animals. We previously reported that the levels of most amino acids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f6a39d4c4bcc4a6bf1046e5727079a
https://research.vumc.nl/en/publications/a572bf02-c4f3-490f-868d-c4a568db7f08

Can peri-ovulatory putrescine supplementation improve egg quality in older infertile women?

Autor: Marie Claude Leveille, Tim Ramsay, Jia Yin Liu, Maralee S. Lawson, Arthur Leader, Yong Tao, X. Johné Liu, Johan Smitz, Hongmei Wang, Alina Tartia, Wei Wu, Mary B. Zelinski

The aging-related decline in fertility is an increasingly pressing medical and economic issue in modern society where women are delaying family building. Increasingly sophisticated, costly, and often increasingly invasive, assisted reproductive clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7760a5e2532eb262250a5bc5887aee88
https://europepmc.org/articles/PMC6439130/

Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)

Autor: Rahman, Anisur, Lamberty, Yves, Schenker, Esther, Cella, Massimo, Languille, Solène, Bordet, Régis, Richardson, Jill, Pifferi, Fabien, Aujard, Fabienne

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2017, 12 (9), pp.e0184822. ⟨10.1371/journal.pone.0184822⟩
PLoS ONE, Vol 12, Iss 9, p e0184822 (2017)
PLoS ONE, 2017, 12 (9), pp.e0184822. ⟨10.1371/journal.pone.0184822⟩

International audience; The development of novel therapeutics to prevent cognitive decline of Alzheimer's disease (AD) is facing paramount difficulties since the translational efficacy of rodent models did not resulted in better clinical results. Cur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a5b74e29145b18039d08a2d3175427a8
https://pubmed.ncbi.nlm.nih.gov/28922421

Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats

Autor: Béatrice Morio, Caroline Kharchi, Christophe Moinard, Agathe Raynaud-Simon, Philippe Noirez, Dominique Bonnefont-Rousselot, Luc Cynober, Arnaud Ferry, Nathalie Neveux, Servane Le Plénier

Publikováno v: Journal of Nutrition
Journal of Nutrition, American Society for Nutrition, 2015, 145 (7), pp.1429-37. ⟨10.3945/jn.114.200626⟩

11 D´ epartement de G´ eriatrie, Hopitaux Universitaires Bichat et Beaujon, AP-HP, Facult´ ed e M´ Abstract Background: Aging is associated with profound metabolic disturbances, and citrulline may be of use to limit them. Objective: The aim of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c48eb40a61f8989a9a04fd73a0daee
https://hal.archives-ouvertes.fr/hal-01850474