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Genetic variants associated with longitudinal changes in brain structure across the lifespan

Autor: Brouwer, Rachel M, Klein, Marieke, Kremen, William S, Guimaraes, Joao P O F T, Homuth, Georg, Hottenga, Jouke-Jan, Knol, Maria J, Kwok, John B J, Le Hellard, Stephanie, Mather, Karen A, Milaneschi, Yuri, Morris, Derek W, Nöthen, Markus M., Panizzon, Matthew S, Papiol, Sergi, Rietschel, Marcella, Santoro, Marcos L, Steen, Vidar M, Stein, Jason L, Streit, Fabian, Tankard, Rick M, Teumer, Alexander, van 't Ent, Dennis, van der Meer, Dennis, Olde Loohuis, Loes M, van Eijk, Kristel R, Vassos, Evangelos, Vázquez-Bourgon, Javier, Witt, Stephanie H, Consortium, IMAGEN, Adams, Hieab H H, Agartz, Ingrid, Ames, David, Amunts, Katrin, Andreassen, Ole A, Whelan, Christopher D, Arango, Celso, Banaschewski, Tobias, Baune, Bernhard T, Belangero, Sintia I, Bokde, Arun L W, Boomsma, Dorret I, Bressan, Rodrigo A, Brodaty, Henry, Buitelaar, Jan K, Cahn, Wiepke, Aghajani, Moji, Caspers, Svenja, Cichon, Sven, Crespo-Facorro, Benedicto, Cox, Simon R, Dannlowski, Udo, Elvsåshagen, Torbjørn, Espeseth, Thomas, Falkai, Peter, Fisher, Simon E, Flor, Herta, Alloza, Clara, Fullerton, Janice M, Garavan, Hugh, Gowland, Penny A, Grabe, Hans, Hahn, Tim, Heinz, Andreas, Hillegers, Manon, Hoare, Jacqueline, Hoekstra, Pieter J, Ikram, Mohammad A, Alnæs, Dag, Jackowski, Andrea P, Jansen, Andreas, Jönsson, Erik G, Kahn, Rene S, Kircher, Tilo, Korgaonkar, Mayuresh S, Krug, Axel, Lemaitre, Herve, Malt, Ulrik F, Martinot, Jean-Luc, Artiges, Eric, McDonald, Colm, Mitchell, Philip B, Muetzel, Ryan L, Murray, Robin M, Nees, Frauke, Nenadić, Igor, Oosterlaan, Jaap, Ophoff, Roel A, Pan, Pedro M, Penninx, Brenda W J H, Ayesa-Arriola, Rosa, Poustka, Luise, Sachdev, Perminder S, Salum, Giovanni A, Schofield, Peter R, Schumann, Gunter, Shaw, Philip, Sim, Kang, Smolka, Michael N, Stein, Dan J, Trollor, Julian N, Barker, Gareth J, van den Berg, Leonard H, Veldink, Jan H, Walter, Henrik, Westlye, Lars T, Whelan, Robert, White, Tonya, Wright, Margaret J, Medland, Sarah E, Franke, Barbara, Thompson, Paul M, Grasby, Katrina L, Bastin, Mark E, Hulshoff Pol, Hilleke E, Brühl, Rüdiger, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Millenet, Sabina, Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A, Bright, Joanna K, Buimer, Elizabeth E L, Bülow, Robin, Cannon, Dara M, Ciufolini, Simone, Crossley, Nicolas A, Schnack, Hugo G, Damatac, Christienne G, Dazzan, Paola, de Mol, Casper L, de Zwarte, Sonja M C, Desrivières, Sylvane, Díaz-Caneja, Covadonga M, Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H, Goltermann, Janik, Jahanshad, Neda, Grigis, Antoine, Grotegerd, Dominik, Han, Laura K M, Harris, Mathew, Hartman, Catharina A, Heany, Sarah J, Heindel, Walter, Heslenfeld, Dirk J., Hohmann, Sarah, Ittermann, Bernd, Teeuw, Jalmar, Jansen, Philip R, Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn G J C, Lenroot, Rhoshel K, Malchow, Berend, Thomopoulos, Sophia I, Mandl, René C W, Medel, Vicente, Meinert, Susanne, Morgan, Catherine A, Mühleisen, Thomas W, Nabulsi, Leila, Opel, Nils, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J, Paillère Martinot, Marie-Laure, Sprooten, Emma, Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V, Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Franz, Carol E, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje E M, Wardlaw, Joanna M, Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zhu, Alyssa H, Zugman, Andre, Gogtay, Nitin, Armstrong, Nicola J, Bonfiglio, Gaia, Bralten, Janita, Dalvie, Shareefa, Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J, Gonzalez-Peñas, Javier

Publikováno v: Nature Neuroscience, 25(4), 421-432. Nature Publishing Group
IMAGEN Consortium 2022, ' Genetic variants associated with longitudinal changes in brain structure across the lifespan ', Nature Neuroscience, vol. 25, no. 4, pp. 421-432 . https://doi.org/10.1038/s41593-022-01042-4
Nature Neuroscience, 25(4), 421-432. NATURE PORTFOLIO
Nature Neuroscience
2022, ' Genetic variants associated with longitudinal changes in brain structure across the lifespan ', Nature Neuroscience, vol. 25, no. 4, pp. 421-432 . https://doi.org/10.1038/s41593-022-01042-4
Nature Neuroscience, 25, 421-432
Nature neuroscience 25(4), 421-432 (2022). doi:10.1038/s41593-022-01042-4
Nature neuroscience, 25(4), 421-432. NATURE AMERICA INC
Nature Neuroscience, 25, 4, pp. 421-432
Nature neuroscience, 25(4), 421-432. Nature Publishing Group

et al.
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5031b078c5be5de68f91ccd30ad38db4
http://www.scopus.com/inward/record.url?scp=85127652829&partnerID=8YFLogxK

Refining epigenetic prediction of chronological and biological age

Autor: Elena Bernabeu, Daniel L McCartney, Danni A Gadd, Robert F Hillary, Ake T Lu, Lee Murphy, Nicola Wrobel, Archie Campbell, Sarah E Harris, David Liewald, Caroline Hayward, Cathie Sudlow, Simon R Cox, Kathryn L Evans, Steve Horvath, Andrew M McIntosh, Matthew R Robinson, Catalina A Vallejos, Riccardo E Marioni

Publikováno v: Bernabeu, E, McCartney, D L, Gadd, D, Hillary, R, Lu, A T, Murphy, L, Wrobel, N, Campbell, A, Harris, S E, Liewald, D C, Hayward, C, Sudlow, C L M, Cox, S R, Evans, K L, Horvath, S, McIntosh, A M, Robinson, M R, Vallejos, C A & Marioni, R E 2023, ' Refining epigenetic prediction of chronological and biological age ', Genome Medicine, vol. 15, no. 1, 12 . https://doi.org/10.1186/s13073-023-01161-y

Background Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). The latter is typically defined by physiological biomarkers and risk of adverse health outcomes, including all-cause mortality. As cohort sample sizes inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d5814cca16d7ebc88338f68a25d155
https://www.pure.ed.ac.uk/ws/files/330163640/s13073_023_01161_y.pdf

The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype

Autor: Frederic S Arendrup, Jens S. Andersen, Marta Montes, Anders H. Lund, Sarunas Tumas, Lea M. Harder, Anders Jacobsen Skanderup, Neha Rohatgi, Bettina Mentz, Michal Lubas

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Montes, M, Lubas, M, Arendrup, F S, Mentz, B, Rohatgi, N, Tumas, S, Harder, L M, Skanderup, A J, Andersen, J S & Lund, A H 2021, ' The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype ', Nature Communications, vol. 12, no. 1, 2459 . https://doi.org/10.1038/s41467-021-22746-4
Montes, M, Lubas, M, Arendrup, F S, Mentz, B, Rohatgi, N, Tumas, S, Harder, L M, Skanderup, A J, Andersen, J S & Lund, A H 2021, ' The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype ', Nature Communications, vol. 12, no. 1, 2459, pp. 1-17 . https://doi.org/10.1038/s41467-021-22746-4

Oncogene-induced senescence provides a barrier against malignant transformation. However, it can also promote cancer through the secretion of a plethora of factors released by senescent cells, called the senescence associated secretory phenotype (SAS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546e726c91808867332c4f90a83cb157
https://doaj.org/article/8da6f54bfa9d4666b2534cafaba5a56a

Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization

Autor: Veerle Dam, N Charlotte Onland-Moret, Stephen Burgess, Maria-Dolores Chirlaque, Sanne A E Peters, Ewoud Schuit, Kaja Tikk, Elisabete Weiderpass, Clare Oliver-Williams, Angela M Wood, Anne Tjønneland, Christina C Dahm, Kim Overvad, Marie-Christine Boutron-Ruault, Matthias B Schulze, Antonia Trichopoulou, Pietro Ferrari, Giovanna Masala, Vittorio Krogh, Rosario Tumino, Giuseppe Matullo, Salvatore Panico, Jolanda M A Boer, W M Monique Verschuren, Marit Waaseth, Maria José Sánchez Pérez, Pilar Amiano, Liher Imaz, Conchi Moreno-Iribas, Olle Melander, Sophia Harlid, Maria Nordendahl, Patrik Wennberg, Timothy J Key, Elio Riboli, Carmen Santiuste, Rudolf Kaaks, Verena Katzke, Claudia Langenberg, Nicholas J Wareham, Heribert Schunkert, Jeanette Erdmann, Christina Willenborg, Christian Hengstenberg, Marcus E Kleber, Graciela Delgado, Winfried März, Stavroula Kanoni, George Dedoussis, Panos Deloukas, Majid Nikpay, Ruth McPherson, Markus Scholz, Andrej Teren, Adam S Butterworth, Yvonne T van der Schouw

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Dam, V, Onland-Moret, N C, Burgess, S, Chirlaque, M-D, Peters, S A E, Schuit, E, Tikk, K, Weiderpass, E, Oliver-Williams, C, Wood, A M, Tjønneland, A, Dahm, C C, Overvad, K, Boutron-Ruault, M-C, Schulze, M B, Trichopoulou, A, Ferrari, P, Masala, G, Krogh, V, Tumino, R, Matullo, G, Panico, S, Boer, J M A, Verschuren, W M M, Waaseth, M, Sánchez Pérez, M J, Amiano, P, Imaz, L, Moreno-Iribas, C, Melander, O, Harlid, S, Nordendahl, M, Wennberg, P, Key, T J, Riboli, E, Santiuste, C, Kaaks, R, Katzke, V, Langenberg, C, Wareham, N J, Schunkert, H, Erdmann, J, Willenborg, C, Hengstenberg, C, Kleber, M E, Delgado, G, März, W, Kanoni, S, Dedoussis, G, Deloukas, P, Nikpay, M, McPherson, R, Scholz, M, Teren, A, Butterworth, A S & van der Schouw, Y T 2022, ' Genetically determined reproductive aging and coronary heart disease : A Bidirectional 2-sample Mendelian Randomization ', The Journal of clinical endocrinology and metabolism, vol. 107, no. 7, pp. e2952–e2961 . https://doi.org/10.1210/clinem/dgac171
Dam, V, Onland-Moret, N C, Burgess, S, Chirlaque, M-D, Peters, S A E, Schuit, E, Tikk, K, Weiderpass, E, Oliver-Williams, C, Wood, A M, Tjønneland, A, Dahm, C C, Overvad, K, Boutron-Ruault, M-C, Schulze, M B, Trichopoulou, A, Ferrari, P, Masala, G, Krogh, V, Tumino, R, Matullo, G, Panico, S, Boer, J M A, Verschuren, W M M, Waaseth, M, Sánchez Pérez, M J, Amiano, P, Imaz, L, Moreno-Iribas, C, Melander, O, Harlid, S, Nordendahl, M, Wennberg, P, Key, T J, Riboli, E, Santiuste, C, Kaaks, R, Katzke, V, Langenberg, C, Wareham, N J, Schunkert, H, Erdmann, J, Willenborg, C, Hengstenberg, C, Kleber, M E, Delgado, G, März, W, Kanoni, S, Dedoussis, G, Deloukas, P, Nikpay, M, McPherson, R, Scholz, M, Teren, A, Butterworth, A S & van der Schouw, Y T 2022, ' Genetically determined reproductive aging and coronary heart disease : A Bidirectional 2-sample Mendelian Randomization ', The Journal of clinical endocrinology and metabolism, vol. 107, no. 7, pp. e2952-e2961 . https://doi.org/10.1210/clinem/dgac171

The EPIC-CVD project was supported by the European Union Framework 7 (HEALTH-F2-2012-279233), the European Research Council (268834), the UK Medical Research Council (G0800270, MR/L003120/1), the British Heart Foundation (SP/09/002, RG/08/014, RG13/1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7706a38294a047f81cbc35eb85ed4236
https://www.repository.cam.ac.uk/handle/1810/336942