Zobrazeno 1 - 10
of 456
pro vyhledávání: '"Aggrephagy"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Protein aggregation, a defining characteristic of numerous human diseases, poses a significant challenge to cellular health. Autophagy, an essential cellular recycling process, specifically targets and degrades these harmful protein aggregates throug
Externí odkaz:
https://doaj.org/article/3791f225a02d4d489857b29d2b078fbc
Autor:
Jing Chen, Zi-Cheng Zhou, Yang Yan, Shu-Zhen Wu, Tao Ma, Han Xuan, Ruo-Chun Wang, Chi-Yu Gu, Yi-Heng Liu, Qing-Qing Liu, Si-Jia Ge, Wei Huang, Cui-Hua Lu
Publikováno v:
Biomedical Technology, Vol 5, Iss , Pp 46-59 (2024)
Background: Liver fibrosis is recognized as a consequence of persistent liver damage. Hence, understanding the mechanisms of liver fibrosis could help patients reverse this process. Aggrephagy is a selective type of autophagy which is under study in
Externí odkaz:
https://doaj.org/article/42926864a385446fbdfd55cd579e224f
Publikováno v:
Mathematical Biosciences and Engineering, Vol 221, Iss 2, Pp 2407-2431 (2024)
Background: Aggrephagy is a lysosome-dependent process that degrades misfolded protein condensates to maintain cancer cell homeostasis. Despite its importance in cellular protein quality control, the role of aggrephagy in glioma remains poorly unders
Externí odkaz:
https://doaj.org/article/72abb6593bd94e10a27383f3510bf402
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-17 (2023)
Abstract Background Ubiquitin–proteasome-system-mediated clearance of misfolded proteins is essential for cells to maintain proteostasis and reduce the proteotoxicity caused by these aberrant proteins. When proteasome activity is inadequate, ubiqui
Externí odkaz:
https://doaj.org/article/556187ca21804285b3e04f5317ba8b7f
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 542-545 (2022)
Externí odkaz:
https://doaj.org/article/4ba1d6d7bb8c4e8bbb048a88f3d21c28
Autor:
Yan Pan, Yingjian Wang, Mengsi Hu, Shoufang Xu, Feiyu Jiang, Yetao Han, Fangjian Chen, Zhiwei Liu
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Acute myeloid leukemia (AML) is a complex mixed entity composed of malignant tumor cells, immune cells and stromal cells, with intra-tumor and inter-tumor heterogeneity. Single-cell RNA sequencing enables a comprehensive study of the highly complex t
Externí odkaz:
https://doaj.org/article/5ce5368fb2674ec19372ce2d85c0e58e
Autor:
Junsheng Yang, Chaoyue Zhang
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
The autophagy-lysosomal pathway (ALP) is the major biological pathway responsible for clearing intracellular protein aggregates, therefore a promising target for treating diseases featuring the accumulation of aggregation-prone proteins, such as Hunt
Externí odkaz:
https://doaj.org/article/9bd076d04b9c4d0ab43b09bb0a71aa26
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8456 (2023)
A number of muscular disorders are hallmarked by the aggregation of misfolded proteins within muscle fibers. A specialized form of macroautophagy, termed aggrephagy, is designated to remove and degrade protein aggregates. This review aims to summariz
Externí odkaz:
https://doaj.org/article/8e3e734e75214b938997ce21133a9499
Autor:
Shengliang Cao, Jiaqi Liu, Guofei Ding, Qingyuan Shao, Bin Wang, Yingchao Li, Jian Feng, Yuzhong Zhao, Sidang Liu, Yihong Xiao
Publikováno v:
Veterinary Research, Vol 51, Iss 1, Pp 1-11 (2020)
Abstract Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is one of the most severe swine diseases that affects almost all swine-breeding countries. Nonstructural protein 2 (NSP2) is one of the most important viral pr
Externí odkaz:
https://doaj.org/article/13e495a256864d62aca470f65f5394a5