Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Aggie Lawer"'
Publikováno v:
Cells, Vol 13, Iss 5, p 426 (2024)
Post-translational modifications (PTMs) are crucial mechanisms that underlie the intricacies of biological systems and disease mechanisms. This review focuses on the latest advancements in the design of heterobifunctional small molecules that hijack
Externí odkaz:
https://doaj.org/article/9177783a2b7e4c1f8be38ce584de8350
Autor:
Raju Cheerlavancha, Ahmed Ahmed, Yun Cheuk Leung, Aggie Lawer, Qing-Quan Liu, Marina Cagnes, Hee-Chan Jang, Xiang-Guo Hu, Luke Hunter
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2316-2325 (2017)
Backbone-extended amino acids have a variety of potential applications in peptide and protein science, particularly if the geometry of the amino acid is controllable. Here we describe the synthesis of δ-amino acids that contain three vicinal C–F b
Externí odkaz:
https://doaj.org/article/8f6f4ba5619d414e9591e238346ecde5
Autor:
Aggie, Lawer, Chelsea, Tyler, Kiel, Hards, Laura M, Keighley, Chen-Yi, Cheung, Fabian, Kierek, Simon, Su, Siddharth S, Matikonda, Tyler, McInnes, Joel D A, Tyndall, Kurt L, Krause, Gregory M, Cook, Allan B, Gamble
Publikováno v:
ACS medicinal chemistry letters. 13(10)
A revised total synthesis of aurachin D (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f774d80355356f787d2c75bad92f6c90
https://pubmed.ncbi.nlm.nih.gov/36262396
https://pubmed.ncbi.nlm.nih.gov/36262396
Autor:
Aggie Lawer, Luke Hunter
Publikováno v:
European Journal of Organic Chemistry. 2021:1184-1190
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::806bf8139f8df8259b3306b17eb8558e
https://doi.org/10.1002/ejoc.202001619
https://doi.org/10.1002/ejoc.202001619
Autor:
Emilie Marotte, Kleopas Y. Palate, Ryan G. Epton, William P. Unsworth, Katie J. Lamb, Aggie Lawer, Thomas C. Stephens, Jade K. Sangha, Jason M. Lynam, Mahendar Lodi
Publikováno v:
CHEMISTRY-A EUROPEAN JOURNAL
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry (Weinheim an Der Bergstrasse, Germany)
The outcome of ring‐expansion reactions based on amino/hydroxyacid side‐chain insertion is strongly dependent on ring size. This manuscript, which builds upon our previous work on Successive Ring Expansion (SuRE) methods, details efforts to bette
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6598983bdb9d85a6195630453a973576
https://doi.org/10.1002/chem.202002164
https://doi.org/10.1002/chem.202002164
Publikováno v:
Tetrahedron. 74:1278-1287
Pepstatin A and grassystatin A are natural, statine-containing peptides that act as inhibitors of aspartic protease enzymes. In this work, stereoselective fluorination is investigated as a strategy for enhancing the pharmacodynamic and pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2a519b56fe28f47781b6a7a021bb88f
https://doi.org/10.1016/j.tet.2017.12.033
https://doi.org/10.1016/j.tet.2017.12.033
Autor:
Qing-Quan Liu, Ahmed M.A. Ahmed, Marina Cagnes, Hee-Chan Jang, Luke Hunter, Xiang-Guo Hu, Yun Cheuk Leung, Raju Cheerlavancha, Aggie Lawer
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2316-2325 (2017)
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2316-2325 (2017)
Backbone-extended amino acids have a variety of potential applications in peptide and protein science, particularly if the geometry of the amino acid is controllable. Here we describe the synthesis of δ-amino acids that contain three vicinal C–F b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b76a2e5f8c619609c6378e46988127
https://doi.org/10.3762/bjoc.13.228
https://doi.org/10.3762/bjoc.13.228
Autor:
Ryan G. Epton, Jason M. Lynam, Bradley J Challis, William P. Unsworth, Thomas C. Stephens, James A. Rossi-Ashton, Aggie Lawer
Publikováno v:
Angewandte Chemie (International ed. in English). 58(39)
A strategy for the synthesis of medium-sized lactones and lactams from linear precursors is described in which an amine acts as an internal nucleophilic catalyst to facilitate a novel cyclisation/ring expansion cascade sequence. This method obviates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab93ce776638802343e08279457ccc01
https://pubmed.ncbi.nlm.nih.gov/31340086
https://pubmed.ncbi.nlm.nih.gov/31340086
Autor:
Johny Trinh, Alpesh Ramanlal Patel, Md. Iqbal Ahmed, Aggie Lawer, Xiang-Guo Hu, Elizabeth Hannah, Catherine Au, Luke Hunter, Christina Gonzalez, Mohan M. Bhadbhade, Rasha Saad Jwad
Publikováno v:
Tetrahedron. 72:3305-3317
Backbone-fluorinated gamma-amino acids are novel shape-controlled building blocks that have potential utility in a variety of biological contexts. However, their synthesis poses challenges in terms of chemo-, regio- and stereoselectivity, and this ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4caa037d73f479011b49f88a15dc567e
https://doi.org/10.1016/j.tet.2016.04.070
https://doi.org/10.1016/j.tet.2016.04.070
Publikováno v:
ChemInform. 45
The synthesis of two novel δ-amino acid derivatives (VII) and (X) containing three vicinal fluorine atoms placed stereospecifically in the backbone is detailed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::941744b29c6363b676fdd6fc84d0fe75
https://doi.org/10.1002/chin.201413220
https://doi.org/10.1002/chin.201413220